DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14185 and LRRC56

DIOPT Version :9

Sequence 1:	NP_649175.1	Gene:	CG14185 / 40197	FlyBaseID:	FBgn0036936	Length:	402	Species:	Drosophila melanogaster
Sequence 2:	NP_932341.1	Gene:	LRRC56 / 115399	HGNCID:	25430	Length:	542	Species:	Homo sapiens

Alignment Length:	349	Identity:	96/349 - (27%)
Similarity:	141/349 - (40%)	Gaps:	83/349 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 PQ-QGPEPTLDEL-------------LRRVTQRTDLEAVEQVRLRVISYTVSLSRLSLFLPRLQS 148
            || :||....|.|             |:.:.:..||..|..:.:.|.:...||....:.||.|..
Human    33 PQSKGPGSQRDRLGEQLVEEYLSPARLQALARVDDLRLVRTLEMCVDTREGSLGNFGVHLPNLDQ 97

  Fly   149 LDLSGSVLSSLRDLGYGLLQLTRLDISNCGLNSFDGTSGLPAIRVLIADGNMIQRVDPLAELVHL 213
            |.|:||.|.||||||..|..|..|.::.|||...||.:.|||::.|.|..|.|..:.||..|..|
Human    98 LKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNISDLSPLCLLEQL 162

  Fly   214 RVLKARNNRISELGLLSFLGMCPQLQEVELQGNPVCRLPL------------YRSLLARSVPTLQ 266
            .||....|.:.:||.:.:|.:||:|..:.|:||.||..|.            ||:.:.:.:|.||
Human   163 EVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEGNLVCLQPAPGPTNKVPRGYNYRAEVRKLIPQLQ 227

  Fly   267 LLD--GRVLNGEPAPVEMEEATSPASSDLESG-------------------------SETTAQRP 304
            :||  .....|.|||..:.:........::.|                         :::.|.||
Human   228 VLDEVPAAHTGPPAPPRLSQDWLAVKEAIKKGNGLPPLDCPRGAPIRRLDPELSLPETQSRASRP 292

  Fly   305 -------NTAPAPEPVPIALNAAIRRQVSASSGSTPVAGSVL-----SLVRQRR----------- 346
                   ...|.||.:   |:..:..:.:.|| .|..||.||     ..:|:||
Human   293 WPFSLLVRGGPLPEGL---LSEDLAPEDNTSS-LTHGAGQVLCGNPTKGLRERRHQCQAREPPEQ 353

  Fly   347 ---RRSGHAWVSSSSSSGSSSASS 367
               .|.|....|:|:.....:.||
Human   354 LPQHRPGDPAASTSTPEPDPADSS 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14185	NP_649175.1	LRR_8	144..201	CDD:290566	27/56 (48%)
		leucine-rich repeat	146..168	CDD:275380	13/21 (62%)
		LRR_4	168..209	CDD:289563	16/40 (40%)
		leucine-rich repeat	169..190	CDD:275380	8/20 (40%)
		leucine-rich repeat	191..212	CDD:275380	7/20 (35%)
		leucine-rich repeat	213..237	CDD:275380	8/23 (35%)
LRRC56	NP_932341.1	LRR_RI	<54..186	CDD:238064	47/131 (36%)
		LRR 1	94..115		12/20 (60%)
		leucine-rich repeat	95..117	CDD:275380	13/21 (62%)
		LRR_8	117..170	CDD:290566	20/52 (38%)
		LRR_4	117..156	CDD:289563	14/38 (37%)
		LRR 2	117..138		7/20 (35%)
		leucine-rich repeat	118..139	CDD:275380	8/20 (40%)
		LRR_4	138..175	CDD:289563	13/36 (36%)
		LRR 3	139..160		7/20 (35%)
		leucine-rich repeat	140..161	CDD:275380	7/20 (35%)
		LRR 4	161..182		6/20 (30%)
		leucine-rich repeat	162..186	CDD:275380	8/23 (35%)
		LRR 5	186..206		7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..377		15/72 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..475
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159954
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008086
OrthoInspector	1	1.000	-	-		oto91516
orthoMCL	1	0.900	-	-		OOG6_105979
Panther	1	1.100	-	-	LDO	PTHR22708
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.730