DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14185 and Dnal1

DIOPT Version :9

Sequence 1:	NP_649175.1	Gene:	CG14185 / 40197	FlyBaseID:	FBgn0036936	Length:	402	Species:	Drosophila melanogaster
Sequence 2:	NP_083097.2	Gene:	Dnal1 / 105000	MGIID:	1921462	Length:	190	Species:	Mus musculus

Alignment Length:	197	Identity:	45/197 - (22%)
Similarity:	80/197 - (40%)	Gaps:	26/197 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 TLDELLRRVTQRTDLEAVEQVRLRVISYTVSLSRLSLFLPRL---QSLDLSGSVLSSLRDLGYGL 166
            |:.|.|.|..::|..:..:...:::.:....:.::...|..|   :.|.||.:.:..:.:|.
Mouse     6 TIKEALSRWEEKTGQKPSDAKEIKLYAQIPPIEKMDASLSTLGNCEKLSLSTNCIEKIANLN--- 67

  Fly   167 LQLTRLDISNCGLNSFDGTSGLPAI----RVLIADGNMIQRVDPLAELVHLRVLKARNNRISELG 227
             .|..|.|.:.|.|:....:||.|:    ..|....|.|:::..:..:..|::|...||.:.:..
Mouse    68 -GLKNLRILSLGRNNIKNLNGLEAVGETLEELWISYNFIEKLKGIHVMKKLKILYMSNNLVKDWA 131

  Fly   228 LLSFLGMCPQLQEVELQGNPVCRLPLYRSL-------LARSVPTLQLLDGRVLNGEPAPVEMEEA 285
            ....|...|.|:::...|||   |....|.       ..:.||.|:.||     |.|...|.||.
Mouse   132 EFLKLAELPCLEDLVFVGNP---LEEKHSAEGNWIDEATKRVPKLKKLD-----GTPVIKEDEEE 188

  Fly   286 TS 287
            .|
Mouse   189 ES 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14185	NP_649175.1	LRR_8	144..201	CDD:290566	15/63 (24%)
		leucine-rich repeat	146..168	CDD:275380	5/24 (21%)
		LRR_4	168..209	CDD:289563	11/44 (25%)
		leucine-rich repeat	169..190	CDD:275380	7/20 (35%)
		leucine-rich repeat	191..212	CDD:275380	3/24 (13%)
		leucine-rich repeat	213..237	CDD:275380	5/23 (22%)
Dnal1	NP_083097.2	LRR_4	49..89	CDD:289563	10/43 (23%)
		LRR 1	49..70		4/24 (17%)
		leucine-rich repeat	50..71	CDD:275378	5/24 (21%)
		LRR_8	70..127	CDD:290566	14/56 (25%)
		LRR 2	71..92		7/20 (35%)
		leucine-rich repeat	72..90	CDD:275378	6/17 (35%)
		LRR 3	94..115		3/20 (15%)
		LRR_4	95..133	CDD:289563	7/37 (19%)
		leucine-rich repeat	95..116	CDD:275382	3/20 (15%)
		LRR 4	116..137		4/20 (20%)
		leucine-rich repeat	117..140	CDD:275382	5/22 (23%)
		leucine-rich repeat	142..172	CDD:275382	7/32 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900