DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14185 and lrrc56

DIOPT Version :9

Sequence 1:	NP_649175.1	Gene:	CG14185 / 40197	FlyBaseID:	FBgn0036936	Length:	402	Species:	Drosophila melanogaster
Sequence 2:	XP_009296335.1	Gene:	lrrc56 / 100149369	ZFINID:	ZDB-GENE-081223-1	Length:	607	Species:	Danio rerio

Alignment Length:	374	Identity:	94/374 - (25%)
Similarity:	162/374 - (43%)	Gaps:	80/374 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 VHLLPVVLPQQGPEPTLD------ELLRRVTQRTDLEAVEQVRLRVISYTVSLSRLSLFLPRLQS 148
            ::|.|...|... :..:|      |:|:.::...||:.|..:.:.|.:...:|....::||:|..
Zfish    25 LNLKPTAEPDHS-DKMMDQLCLSLEILKILSGSDDLQEVTSLEMCVDTRQDTLDNFGVYLPKLTQ 88

  Fly   149 LDLSGSVLSSLRDLGYGLLQLTRLDISNCGLNSFDGTSGLPAIRVLIADGNMIQRVDPLAELVHL 213
            |.::.|::||:||||..|..|..|.::.|.|...:|...|.:::.|....|.|..:.|::.|.:|
Zfish    89 LKMNNSLISSVRDLGTSLSHLQILWLARCSLTDLEGLPALSSLKELYVAYNSISDLSPVSMLENL 153

  Fly   214 RVLKARNNRISELGLLSFLGMCPQLQEVELQGNPVCRLP----------LYRSLLARSVPTLQLL 268
            .:|....|.:.||..|.:||.|.:|:.:.|:|||||..|          .|||::...:|.|.:|
Zfish   154 ELLDLEGNNVDELAQLWYLGCCEKLRTLSLEGNPVCTCPDSGKLEASHYSYRSVVRELIPQLNIL 218

  Fly   269 DGRVLNGEPAPVEMEEATSPASS------------------DLE---------SGSETTAQRPNT 306
            |       ..|||:|::....||                  ||:         |.||:..:..:.
Zfish   219 D-------DVPVELEKSQCNGSSLLDWTLLKESIKDSSVIVDLDHRDAAIEERSVSESGIRPASA 276

  Fly   307 AP-----APEPVPIALNAAIRRQVSASSGSTP-VAGSVLSLVRQRRRRSGHAWVSSSSSSGSSS- 364
            .|     :|..:...|::|  |..:..:||.| .|||||:::...         :|..::|..:
Zfish   277 LPLDLRNSPRSLSNHLDSA--RPSTFCTGSRPGSAGSVLAILNHE---------ASDLTNGVGTV 330

  Fly   365 --ASSARSTRAPSMSSCSSNSSLDVQSSSH---------YVFSTQSTLD 402
              .:..::.||........||...:|.|:.         |.|...|:.|
Zfish   331 LCGNPLQAVRARRQKIKLQNSQSQIQPSTQLSSYIPEHTYDFEQSSSQD 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14185	NP_649175.1	LRR_8	144..201	CDD:290566	19/56 (34%)
		leucine-rich repeat	146..168	CDD:275380	10/21 (48%)
		LRR_4	168..209	CDD:289563	10/40 (25%)
		leucine-rich repeat	169..190	CDD:275380	6/20 (30%)
		leucine-rich repeat	191..212	CDD:275380	5/20 (25%)
		leucine-rich repeat	213..237	CDD:275380	9/23 (39%)
lrrc56	XP_009296335.1	leucine-rich repeat	86..108	CDD:275380	10/21 (48%)
		LRR_9	88..229	CDD:258718	48/147 (33%)
		LRR_4	108..148	CDD:289563	10/39 (26%)
		leucine-rich repeat	109..130	CDD:275380	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596242
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008086
OrthoInspector	1	1.000	-	-		oto40594
orthoMCL	1	0.900	-	-		OOG6_105979
Panther	1	1.100	-	-	LDO	PTHR22708
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.840