Protein Alignment CG14186 and TMEM237

DIOPT Version :10

• Sequence 1: NP_649174.1
• Gene: CG14186 / 40196
• FlyBaseID: FBgn0036935
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_001037850.1
• Gene: TMEM237 / 65062
• HGNCID: 14432
• Length: 408
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 90/590 - (15%)
• Similarity: 177/590 - (30%)
• Gaps: 218/590 - (36%)

  Fly   108 EEGEEESPLGAGNTRDSPPPPKQSDGSRNSSGDAMSLRETLQQLPATHHHRSRRTHSPADPDASF 172
            |||....|      |..||.|.|.|         :.|....::.|.|
Human    10 EEGHLRPP------RALPPVPSQDD---------IPLSRPKKKKPRT------------------ 41

  Fly   173 HRGILGYMDRELKQSSPTPSAPAGTGNGTGNGTSTGASRKQQSLSDPQASPAQR---SLRSRSSF 234
                         :::|..::..|.....|...|.|.....:.|.:...:|.||   ..|.....
Human    42 -------------KNTPASASLEGLAQTAGRRPSEGNEPSTKELKEHPEAPVQRRQKKTRLPLEL 93

  Fly   235 DKSPRRKRSKSESRRRRERKLIAAGEMEVRQANETLMRYLKQCSDMHDASLSGELEIDQSLEERR 299
            :.|..:|:|.|.|..|.|..:                          ||..:.|..|      ::
Human    94 ETSSTQKKSSSSSLLRNENGI--------------------------DAEPAEEAVI------QK 126

  Fly   300 VHRKTKSQRDKRGQLISKLYSAGGISSILKE--LADDIAPADGEEIYNPFTPVVSPTDDAPAHID 362
            ..||||..:....|..::|    |:..   |  :.|:....:.:.::...|.:..|       :.
Human   127 PRRKTKKTQPAELQYANEL----GVED---EDIITDEQTTVEQQSVFTAPTGISQP-------VG 177

  Fly   363 KMFLQTSSGYRPVEHSYYKRSFLGAAVRGSAGISASGGGGGCAGGGGGRLDGISAAELGGAGRLF 427
            |:|::.|..::..:.|        ..::.:..|..|
Human   178 KVFVEKSRRFQAADRS--------ELIKTTENIDVS----------------------------- 205

  Fly   428 RSSGSHAHGGDRMGGNGSGRGSYGDTRCLLDADFNRNGITSNIQLACVVQRIWLLISNICHGLLA 492
                                           .|...:..|.::  |..|.|.:.:|....||.||
Human   206 -------------------------------MDVKPSWTTRDV--ALTVHRAFRMIGLFSHGFLA 237

  Fly   493 GLALAHLLFVLSSHPMDWAKVINGMSLAGETVSSTAQPPAASTPSAIDIDSGDRGTESGESSSPS 557
            |.|:.:::.:              ..|||:.:|:.:.
Human   238 GCAVWNIVVI--------------YVLAGDQLSNLSN---------------------------- 260

  Fly   558 AAASGLALISDYAGFAEIYLNTFYCLAIICLVSVFDRMDICRWSFSNASELISFRWLIITMIYVA 622
                   |:..|...|..:.:..|.|..:..:|.|||:|..:.|.:..:.|......:.:.:|..
Human   261 -------LLQQYKTLAYPFQSLLYLLLALSTISAFDRIDFAKISVAIRNFLALDPTALASFLYFT 318

  Fly   623 TIILAICSDSIDEKLYLFN-NNANITLTQQEMLSNSVQSVWSSLSVTRSIAAISGWIMIGLTPQE 686
            .:||::......::::|:. ::.|.:|.:.. :...:...|..:::..::.....|:.:...|..
Human   319 ALILSLSQQMTSDRIHLYTPSSVNGSLWEAG-IEEQILQPWIVVNLVVALLVGLSWLFLSYRPGM 382

  Fly   687 DMLYE 691
            |:..|
Human   383 DLSEE 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14186	NP_649174.1	PRK07764	<17..>173	CDD:236090	13/64 (20%)
		TMEM237	<565..687	CDD:464690	21/122 (17%)
TMEM237	NP_001037850.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..137		38/204 (19%)
		TMEM237	140..383	CDD:464690	50/376 (13%)