DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sNPF-R and NPY2R

DIOPT Version :9

Sequence 1:	NP_001262086.1	Gene:	sNPF-R / 40195	FlyBaseID:	FBgn0036934	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_000901.1	Gene:	NPY2R / 4887	HGNCID:	7957	Length:	381	Species:	Homo sapiens

Alignment Length:	354	Identity:	121/354 - (34%)
Similarity:	177/354 - (50%)	Gaps:	65/354 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 VQIFFYVLYATVFVLGVFGNVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVPFTPLYTFM 126
            ||:...:.|.::.:|||.||.||.:||::.::|:||||.||.|||::|:|:..|.:|||..||.|
Human    49 VQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLM 113

  Fly   127 GRWAFGRSLCHLVSFAQGCSIYISTLTLTSIAIDRYFVIIYPFHPRMKLSTCIG--IIVSIWVIA 189
            |.|..|..|||||.:|||.::.:||:|||.||:||:..|:|  |...|:|..|.  ||...|.|:
Human   114 GEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVY--HLESKISKRISFLIIGLAWGIS 176

  Fly   190 LLATVPYGMYMKMTNELVNGTQTGNETLVEATLMLNGSFVAQGSGFIEAPDSTSATQAYMQVMTA 254
            .|...|..::.:.             :|:|.                 .||
Human   177 ALLASPLAIFREY-------------SLIEI-----------------IPD-------------- 197

  Fly   255 GSTGPEMPYVRVYCEENWPSEQ---YRKVFGAITTTLQFVLPFFIISICYVWISVKLNQRARAKP 316
                    :..|.|.|.||.|:   |..|:...:..:.:|||..|||..|..|..||  :....|
Human   198 --------FEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKL--KNHVSP 252

  Fly   317 GSKSSRREEADRDRKKRTNRMLIAMVAVFGLSWLPINVVNIFDDFDDKSNEWRFYILFFFVAHSI 381
            |:.:....:    |:::|.:||:.:|.||.:||||::...:..|.|.:..:.:.|.|.|.|.|.|
Human   253 GAANDHYHQ----RRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHII 313

  Fly   382 AMSSTCYNPFLYAWLNENFRKEFKHVLPC 410
            ||.||..||.||.|:|.|:||.|.....|
Human   314 AMCSTFANPLLYGWMNSNYRKAFLSAFRC 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sNPF-R	NP_001262086.1	7tm_4	75..>196	CDD:304433	59/122 (48%)
sNPF-R	NP_001262086.1	7tm_1	80..393	CDD:278431	106/317 (33%)
NPY2R	NP_000901.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		7tmA_NPY2R	51..336	CDD:320521	117/344 (34%)
		TM helix 1	52..78	CDD:320521	10/25 (40%)
		TM helix 2	85..110	CDD:320521	13/24 (54%)
		TM helix 3	123..153	CDD:320521	16/29 (55%)
		TM helix 4	164..185	CDD:320521	7/20 (35%)
		TM helix 5	216..245	CDD:320521	9/28 (32%)
		TM helix 6	261..291	CDD:320521	11/33 (33%)
		TM helix 7	304..329	CDD:320521	14/24 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5469
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41034
orthoMCL	1	0.900	-	-		OOG6_102619
Panther	1	1.100	-	-	O	PTHR24235
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3808
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.890