Protein Alignment sNPF-R and NMBR

DIOPT Version :10

• Sequence 1: NP_524176.1
• Gene: sNPF-R / 40195
• FlyBaseID: FBgn0036934
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_002502.2
• Gene: NMBR / 4829
• HGNCID: 7843
• Length: 390
• Species: Homo sapiens
• Alignment Length: 399
• Identity: 97/399 - (24%)
• Similarity: 178/399 - (44%)
• Gaps: 68/399 - (17%)

  Fly    22 LPLVSTTNWSLTSPGTTSAILAD------VAASDEDRSGGIIHNQFVQIFFYVLYATVFVLGVFG 80
            :|..|.:|.|:|:....|..:.:      :.|||     |......::.....||..:..:|:.|
Human     1 MPSKSLSNLSVTTGANESGSVPEGWERDFLPASD-----GTTTELVIRCVIPSLYLLIITVGLLG 60

  Fly    81 NVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVPFTPLYTFMGRWAFGRSLCHLVSFAQGC 145
            |:::..:.:.|.||::|.||||:|||..|:||.:..||......|...|.||:..|.|:...|..
Human    61 NIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLT 125

  Fly   146 SIYISTLTLTSIAIDRYFVIIYPFHPRMK---LSTCIGIIVSIWVIALLATVPYGMYMKMTNELV 207
            |:.:|..|||:::.|||..|:.|...:..   |.||:. .:.|||:::|..||..::.::..
Human   126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVK-AMGIWVVSVLLAVPEAVFSEVAR--- 186

  Fly   208 NGTQTGNETLVEATLMLNGSFVAQGSGFIEAPDSTSATQAYMQVMTAGSTGPEMPYVRVYCEENW 272
                                        |.:.|::|.|..             :||.:.
Human   187 ----------------------------ISSLDNSSFTAC-------------IPYPQT------ 204

  Fly   273 PSEQYRKVFGAITTTLQFVLPFFIISICYVWISVKLNQRARAKPGSKSSRREEADRDRKKRTNRM 337
             .|.:.|:...:...:.|::|..||||.|..|:..|.:.|...||..:...:: ..:.:||..::
Human   205 -DELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKK-QMETRKRLAKI 267

  Fly   338 LIAMVAVFGLSWLPINVVNIFDDFD-DKSNEWRFYILFFFVAHSIAMSSTCYNPFLYAWLNENFR 401
            ::..|..|...|.|.:::.::..|: ::.:....:::...||..::..::|.|||....|:|:||
Human   268 VLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFR 332

  Fly   402 KEFKHVLPC 410
            :.|...|.|
Human   333 RHFNSQLCC 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sNPF-R	NP_524176.1	7tmA_NPYR-like	64..404	CDD:320331	84/343 (24%)
		TM helix 1	65..91	CDD:320331	5/25 (20%)
		TM helix 2	98..123	CDD:320331	12/24 (50%)
		TM helix 3	136..166	CDD:320331	11/29 (38%)
		TM helix 4	177..198	CDD:320331	8/20 (40%)
		TM helix 5	278..307	CDD:320331	9/28 (32%)
		TM helix 6	329..359	CDD:320331	6/29 (21%)
		TM helix 7	372..397	CDD:320331	6/24 (25%)
NMBR	NP_002502.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		6/20 (30%)
		7tmA_NMBR	44..335	CDD:320253	84/343 (24%)
		TM helix 1	45..71	CDD:320253	5/25 (20%)
		TM helix 2	78..104	CDD:320253	12/25 (48%)
		TM helix 3	116..146	CDD:320253	11/29 (38%)
		TM helix 4	158..178	CDD:320253	8/20 (40%)
		TM helix 5	209..234	CDD:320253	8/24 (33%)
		TM helix 6	259..289	CDD:320253	6/29 (21%)
		TM helix 7	303..328	CDD:320253	6/24 (25%)