DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sNPF-R and npy7r

DIOPT Version :9

Sequence 1:	NP_001262086.1	Gene:	sNPF-R / 40195	FlyBaseID:	FBgn0036934	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001007219.1	Gene:	npy7r / 449010	ZFINID:	ZDB-GENE-040924-9	Length:	372	Species:	Danio rerio

Alignment Length:	415	Identity:	121/415 - (29%)
Similarity:	189/415 - (45%)	Gaps:	93/415 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TSPGTTSAILADVAASDEDRSGGIIHNQFVQIFFYVLYATVFVLGVFGNVLVCYVVLRNRAMQTV 97
            ||.|..|......|..|:     |..:..|||...:.|:.:.:||:.||.||.|:::..|.|:||
Zfish    22 TSLGNDSVNTYKPAFVDD-----ITKHLSVQISLILAYSLIILLGLVGNTLVIYMIILYRNMRTV 81

  Fly    98 TNIFITNLALSDILLCVLAVPFTPLYTFMGRWAFGRSLCHLVSFAQGCSIYISTLTLTSIAIDRY 162
            ||.||.||||:|:::..:.:|||.:||.:..|.||..:||:|.::|..|:::|.||||.||::||
Zfish    82 TNYFIANLALADLMVDTVCLPFTLVYTLLDEWKFGAVMCHMVPYSQALSVHVSILTLTIIALERY 146

  Fly   163 FVIIYPFHPRMKLSTCIGIIV--SIWVIALLATVPYGMYMKMTNELVNGTQTGNETLVEATLMLN 225
            ..|:  ||...:|:.|...|:  ..|..|.:...|..::.:...|
Zfish   147 RCIV--FHLGQRLNRCTSFIIIGLTWAFAAILAGPLAIFREYRYE-------------------- 189

  Fly   226 GSFVAQGSGFIEAPDSTSATQAYMQVMTAGSTGPEMPYVRV---YCEENWPSEQYRK--VFGAIT 285
                                              |:||:.:   .|.|.||:...|.  ::....
Zfish   190 ----------------------------------EIPYIDLRIAVCSEKWPNGTNRDAVIYSLSM 220

  Fly   286 TTLQFVLPFFIISICYVWISVKLNQRARAKPGSKSSRREEADRDRKKRTNRMLIAMVAVFGLSWL 350
            ..||:|:|..|||..||.|.:||....     |.|:|.:..  .|:|:|.:||..:|.||.:.||
Zfish   221 LLLQYVVPLAIISYAYVCIWIKLKNHV-----SPSNRNDGI--VRRKKTTKMLALVVVVFAVCWL 278

  Fly   351 PINVVNIFDDFDDKSNEWRFYILFFFVAHSIAMSSTCYNPFLYAWLNENFRKEFKHVLPCFNPSN 415
            |.::..:..|. |...:::.|.|.:.:.|.:||.||..||.||.|:|:|:|..|.....|.:..:
Zfish   279 PFHMFQLASDL-DLILKFKEYKLIYTLFHIVAMCSTFVNPLLYGWMNQNYRNGFLMFFRCEHKPD 342

  Fly   416 N--------------NIINITRGYN 426
            :              .|:|   |||
Zfish   343 SIYPDGSFRTRSLRGMIVN---GYN 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sNPF-R	NP_001262086.1	7tm_4	75..>196	CDD:304433	50/122 (41%)
sNPF-R	NP_001262086.1	7tm_1	80..393	CDD:278431	95/319 (30%)
npy7r	NP_001007219.1	7tm_GPCRs	48..331	CDD:333717	105/346 (30%)
		TM helix 1	50..74	CDD:320095	8/23 (35%)
		TM helix 2	83..105	CDD:320095	10/21 (48%)
		TM helix 3	121..143	CDD:320095	10/21 (48%)
		TM helix 4	164..180	CDD:320095	3/15 (20%)
		TM helix 5	214..237	CDD:320095	7/22 (32%)
		TM helix 6	260..285	CDD:320095	10/24 (42%)
		TM helix 7	299..324	CDD:320095	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	192	1.000	Inparanoid score	I3847
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25124
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X589
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.060