DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sNPF-R and Gpr165

DIOPT Version :9

Sequence 1:	NP_001262086.1	Gene:	sNPF-R / 40195	FlyBaseID:	FBgn0036934	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001100052.1	Gene:	Gpr165 / 296866	RGDID:	1564566	Length:	462	Species:	Rattus norvegicus

Alignment Length:	426	Identity:	102/426 - (23%)
Similarity:	190/426 - (44%)	Gaps:	101/426 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ITTTSSSISTSQLPLVSTTNWSLTSPGTTSAI-----LADVAASD---EDRSGG-----IIHNQF 61
            ||:|:|.:    |...|....::...|....:     |||..::.   .|.||.     :..::.
  Rat    40 ITSTTSQV----LQAASNAASAVGHAGRNGMLSKMDKLADHMSNTGDLADTSGPLDLEIVSQDEQ 100

  Fly    62 VQIFFYVLYATVFVLGVFGNVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVPFTPLYTFM 126
            ||.:..|.|..|....:.||.::.:::::.:.:.|.|.:|:.|:::::::|.:|:.|||.:....
  Rat   101 VQFWLVVGYTIVVFAAIIGNWVLNHIIMKYKRVHTATGLFVVNISVTNMMLALLSSPFTMVRYLC 165

  Fly   127 GRWAFGRSLCHLVSFAQGCSIYISTLTLTSIAIDRYFVIIYPFHPR---MKLSTCIGIIVSIWVI 188
            ....||:..|||..|||....|::.:::.:|::||:.|::||...|   |:.:.|   |:.||::
  Rat   166 NSLVFGKMTCHLSRFAQYSCAYVTVMSMAAISLDRHRVMLYPLKARITPMQGNVC---IIIIWIV 227

  Fly   189 ALLATVPYGMYMKMTNELVNGTQTGNETLVEATLMLNGSFVAQGSGFIEAPDSTSATQAYMQVMT 253
            :..|.:|:.:|.|:..     .:.||.|...|.|
  Rat   228 STCAALPHAVYQKLYQ-----VEFGNTTEESACL------------------------------- 256

  Fly   254 AGSTGPEMPYVRVYCEENWPSEQYRKVFGAITTTLQFVLPFFIISICY------VWI-----SVK 307
                 |..||.   .:..|      |.....|..|.|:||..::...|      :||     .:.
  Rat   257 -----PSFPYT---SKSTW------KYLDLGTFLLFFILPLLVLVAVYGHVAKKLWIHDAVDDIN 307

  Fly   308 LNQRARAKPGSKSSRREEADRDRKKRTNRMLIAMVAVFGLSWLPINVVNIFDDFDDKSNEWRFYI 372
            ::...             ..|.:||:|.:||:.:|.::.:||||:|:..:....:..|:....|
  Rat   308 IHTYI-------------CQRGKKKQTLKMLMTVVLLYTISWLPLNLYLVLLSSESISSHNGLY- 358

  Fly   373 LFFFVAHSIAMSSTCYNPFLYAWLNENFRKEFKHVL 408
               |..|.:|:||:||||::|.||:::||.|.:.|:
  Rat   359 ---FFLHWLAISSSCYNPYIYCWLSDSFRIEVQKVI 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sNPF-R	NP_001262086.1	7tm_4	75..>196	CDD:304433	33/123 (27%)
sNPF-R	NP_001262086.1	7tm_1	80..393	CDD:278431	77/326 (24%)
Gpr165	NP_001100052.1	7tmA_GPR83	103..387	CDD:320511	85/353 (24%)
		TM helix 1	105..129	CDD:320511	5/23 (22%)
		TM helix 2	138..160	CDD:320511	6/21 (29%)
		TM helix 3	176..198	CDD:320511	7/21 (33%)
		TM helix 4	219..235	CDD:320511	5/18 (28%)
		TM helix 5	268..291	CDD:320511	6/22 (27%)
		TM helix 6	322..344	CDD:320511	8/21 (38%)
		TM helix 7	355..380	CDD:320511	12/28 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910