DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sNPF-R and Prlhr

DIOPT Version :9

Sequence 1:	NP_001262086.1	Gene:	sNPF-R / 40195	FlyBaseID:	FBgn0036934	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_631932.4	Gene:	Prlhr / 246075	RGDID:	71037	Length:	370	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	130/404 - (32%)
Similarity:	200/404 - (49%)	Gaps:	67/404 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TTTSSSISTSQLPLVST-TNWSL-TSPGTTSAILADVAASDEDRSGGIIHNQFVQIFFYVLYATV 73
            ||....:.:...|..|| .|.|. .|....||.:...||....:|..::|.  ::....:||:.|
  Rat     8 TTGDPDLFSGPSPAGSTPANQSAEASESNVSATVPRAAAVTPFQSLQLVHQ--LKGLIVMLYSIV 70

  Fly    74 FVLGVFGNVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVPFTPLYTFMGR-WAFGRSLCH 137
            .|:|:.||.|:..|:.|.|.:..|||..|.||||||:|:|...||.|..|.|..| |.||..|||
  Rat    71 VVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCAACVPLTLAYAFEPRGWVFGGGLCH 135

  Fly   138 LVSFAQGCSIYISTLTLTSIAIDRYFVIIYPFHPRMKLSTCIGIIVSIWVIALLATVPYGMYMKM 202
            ||.|.|..::|:|..|||:||:|||.|:::|...|:.|......::.||.::.:..:|
  Rat   136 LVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLKLSAYAVLGIWALSAVLALP------- 193

  Fly   203 TNELVNGTQTGNETLVEATLMLNGSFVAQGSGFIEAPDSTSATQAYMQVMTAGSTGPEMPYVRVY 267
                                                    :|...|...:        .|:....
  Rat   194 ----------------------------------------AAVHTYHVEL--------KPHDVRL 210

  Fly   268 CEENWPS-EQYRKVF--GAITTTLQFVLPFFIISICYVWISVKLNQRARAKPGSKSSRREEADRD 329
            |||.|.| |:.|:::  |.:..|  ::||...|.:.||.:||||  |.|..|||.:..:.:.||.
  Rat   211 CEEFWGSQERQRQIYAWGLLLGT--YLLPLLAILLSYVRVSVKL--RNRVVPGSVTQSQADWDRA 271

  Fly   330 RKKRTNRMLIAMVAVFGLSWLPINVVNIFDDFDDKSNEWRFYILFFFVAHSIAMSSTCYNPFLYA 394
            |::||..:|:.:|.||.:.|||:::.|:..|.|.::.:...:.|...:.|.:||||.|||||:||
  Rat   272 RRRRTFCLLVVVVVVFAVCWLPLHIFNLLRDLDPRAIDPYAFGLVQLLCHWLAMSSACYNPFIYA 336

  Fly   395 WLNENFRKEFKHVL 408
            ||:::||:|.:.:|
  Rat   337 WLHDSFREELRKML 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sNPF-R	NP_001262086.1	7tm_4	75..>196	CDD:304433	52/121 (43%)
sNPF-R	NP_001262086.1	7tm_1	80..393	CDD:278431	103/316 (33%)
Prlhr	NP_631932.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		7/25 (28%)
		7tmA_PrRP_R	61..346	CDD:320516	114/343 (33%)
		TM helix 1	63..87	CDD:320516	9/23 (39%)
		TM helix 2	96..118	CDD:320516	12/21 (57%)
		TM helix 3	135..157	CDD:320516	11/21 (52%)
		TM helix 4	178..194	CDD:320516	3/62 (5%)
		TM helix 5	223..246	CDD:320516	5/24 (21%)
		TM helix 6	277..299	CDD:320516	7/21 (33%)
		TM helix 7	314..339	CDD:320516	14/24 (58%)
		Required for interaction with GRIP1, GRIP2 and PICK1. /evidence=ECO:0000250	365..370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3134
Inparanoid	1	1.050	230	1.000	Inparanoid score	I3369
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1072979at2759
OrthoFinder	1	1.000	-	-		FOG0004089
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24235
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X589
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	9.030