DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sNPF-R and FPR2

DIOPT Version :9

Sequence 1:	NP_001262086.1	Gene:	sNPF-R / 40195	FlyBaseID:	FBgn0036934	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001005738.1	Gene:	FPR2 / 2358	HGNCID:	3827	Length:	351	Species:	Homo sapiens

Alignment Length:	373	Identity:	93/373 - (24%)
Similarity:	148/373 - (39%)	Gaps:	104/373 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 VQIFFYVLYATVFVLGVFGNVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVPFTPLYTFM 126
            ::|...|:....|||||.||.||.:|. ..|..:|||.|...||||:|... ...:||..:...|
Human    25 LRILPLVVLGVTFVLGVLGNGLVIWVA-GFRMTRTVTTICYLNLALADFSF-TATLPFLIVSMAM 87

  Fly   127 G-RWAFGRSLCHLVSFAQGCSIYISTLTLTSIAIDRYFVIIYPF--HPRMKLSTCIGIIVSIWVI 188
            | :|.||..||.|:......:::.|...:..||:||...:::|.  .....:|..:.:||..|::
Human    88 GEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWIL 152

  Fly   189 ALLATVPYGMYMKMTNELVNGTQTGNETLVEATLMLNGSFVAQGSGFIEAPDSTSATQAYMQVMT 253
            ||:.|:|..:::                                         |:.|
Human   153 ALVLTLPVFLFL-----------------------------------------TTVT-------- 168

  Fly   254 AGSTGPEMPYVRVYCEENWPS-----EQYRKVF-------GAITTTLQFVLPFFIISICYVWISV 306
                   :|....||..|:.|     |:..||.       |.|...:.|.||..|::|||..|:.
Human   169 -------IPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAA 226

  Fly   307 KLNQRARAKPGSKSSRREEADRDRKKRTNRMLIAMVAVFGLSWLPINVVNIFDDFDDKSNEWRFY 371
            |::::...|               ..|..|:|.|:||.|.:.|.|..:|.:.      ...|...
Human   227 KIHKKGMIK---------------SSRPLRVLTAVVASFFICWFPFQLVALL------GTVWLKE 270

  Fly   372 ILFF----------FVAHSIAMSSTCYNPFLYAWLNENFRKEFKHVLP 409
            :||:          ....|:|..::|.||.||.::.::||:...|.||
Human   271 MLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLP 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sNPF-R	NP_001262086.1	7tm_4	75..>196	CDD:304433	42/123 (34%)
sNPF-R	NP_001262086.1	7tm_1	80..393	CDD:278431	79/337 (23%)
FPR2	NP_001005738.1	7tmA_FPR-like	27..313	CDD:320245	90/364 (25%)
		TM helix 1	28..54	CDD:320245	11/26 (42%)
		TM helix 2	60..85	CDD:320245	9/25 (36%)
		TM helix 3	98..128	CDD:320245	7/29 (24%)
		TM helix 4	140..160	CDD:320245	7/19 (37%)
		TM helix 5	198..223	CDD:320245	9/24 (38%)
		TM helix 6	234..264	CDD:320245	11/50 (22%)
		TM helix 7	281..306	CDD:320245	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	325..351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910