DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sNPF-R and npr-5

DIOPT Version :9

Sequence 1:	NP_001262086.1	Gene:	sNPF-R / 40195	FlyBaseID:	FBgn0036934	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001024265.1	Gene:	npr-5 / 190386	WormBaseID:	WBGene00021983	Length:	433	Species:	Caenorhabditis elegans

Alignment Length:	429	Identity:	135/429 - (31%)
Similarity:	208/429 - (48%)	Gaps:	79/429 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ANLSWLSTITTTSSSISTSQLPLVSTTNWSLTSPGTTSAILADVAASDEDRSGGIIHNQFVQIFF 66
            |.:|.:|| |||.|:||.     |.|::   ::.|:...|...:||...|   .|..:.:::..|
Worm     6 ATISTIST-TTTPSTISN-----VITSH---SNNGSCIQIAEAIAAQGID---DITVDFYIRSIF 58

  Fly    67 YVLYATVFVLGVFGNVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVPFTPLYTFMGRWAF 131
            ..||..:||||:|||..|.:.|.||:.:|:..|:|:.||..:|::|...|:|.||.|.....|||
Worm    59 TFLYGFLFVLGIFGNGGVLWAVARNKRLQSARNVFLLNLIFTDLILVFTAIPVTPWYAMTKDWAF 123

  Fly   132 GRSLCHLVSFAQGCSIYISTLTLTSIAIDRYFVIIYPFHPRMKLSTCIGIIVSIWVIALLATVPY 196
            |..:||||..:..||:::::.:||:|::|::..|..|....:.:...:.|...||:::.|..:||
Worm   124 GSVMCHLVPLSNSCSVFVTSWSLTAISLDKFLHINDPTKQPVSIRQALAITFLIWIVSTLINLPY 188

  Fly   197 GMYMKMTNELVNGTQTGNETLVEATLMLNGSFVAQGSGFIEAPDSTSATQAYMQVMTAGSTGPEM 261
            .|..:                     .::|||..|..                          |.
Worm   189 LMSFE---------------------HVDGSFYVQPG--------------------------ET 206

  Fly   262 PYVRVYCEE-NWPSEQYRKVFGAITTTLQFVLPFFIISICYVWISVKLN-----QRARAKPGSKS 320
            ||...:|:| ||.||..||::|.....||||:|..:|:.||..|..|::     |.|:.......
Worm   207 PYCGHFCDEANWQSENSRKIYGTTVMLLQFVVPMAVITYCYFKILQKVSKDMIIQNAQFCQSLTQ 271

  Fly   321 SRREEADRDRKKRTNRMLIAMVAVFGLSWLPINVVNIFDDFDDKSNEWRFYILFFFV--AHSIAM 383
            .:|.:| ..|||:.|.:|||||..|...|||:.::|:..|| .|..||.....||:.  ||.|||
Worm   272 KQRSDA-TSRKKKVNYILIAMVVTFIGCWLPLTLLNLVKDF-KKEPEWLKRQPFFWAINAHVIAM 334

  Fly   384 SSTCYNPFLYAWLNENFRKEFKHVLPCFNPSNNNIINIT 422
            |...:||.|:.||.   ||:.:..|       :.|:|.|
Worm   335 SLVVWNPLLFFWLT---RKQKRSGL-------SKILNST 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sNPF-R	NP_001262086.1	7tm_4	75..>196	CDD:304433	42/120 (35%)
sNPF-R	NP_001262086.1	7tm_1	80..393	CDD:278431	100/320 (31%)
npr-5	NP_001024265.1	7tmA_NPYR-like	56..347	CDD:320331	109/339 (32%)
		TM helix 1	58..82	CDD:320331	12/23 (52%)
		TM helix 2	91..113	CDD:320331	8/21 (38%)
		TM helix 3	129..151	CDD:320331	8/21 (38%)
		TM helix 4	172..188	CDD:320331	4/15 (27%)
		TM helix 5	225..248	CDD:320331	9/22 (41%)
		TM helix 6	282..307	CDD:320331	11/24 (46%)
		TM helix 7	323..347	CDD:320331	11/23 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163623
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	189	1.000	Inparanoid score	I2571
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1072979at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.000