Protein Alignment sNPF-R and npr-35

DIOPT Version :10

• Sequence 1: NP_524176.1
• Gene: sNPF-R / 40195
• FlyBaseID: FBgn0036934
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_001023088.2
• Gene: npr-35 / 183681
• WormBaseID: WBGene00016842
• Length: 384
• Species: Caenorhabditis elegans
• Alignment Length: 460
• Identity: 98/460 - (21%)
• Similarity: 172/460 - (37%)
• Gaps: 128/460 - (27%)

  Fly    25 VSTTNWSLTSPGTTSAILADVAASDEDRSGGIIHNQFVQIFFYVLYATVFVLGVFGNVLVCYVVL 89
            :.|.|.|...|     :.|||...:....  :.|:..:.:.:.|.|..||..||.||..|...|.
 Worm     1 METMNTSFVEP-----LYADVEQLEPVPL--LRHSYQLTVLYTVAYGAVFFTGVLGNTFVVLAVW 58

  Fly    90 RNRAMQTVTNIFITNLALSDILLCVLAVPFTPLYTFMGRWAFGRSLCHLVSFAQGCSIYISTLTL 154
            .::.:...|:..|.:|||:|:.:..:.:|.|.:.:....|.:|:..|.|.::|...:.:.|..||
 Worm    59 AHKNLNITTDYLILSLALADLFILWICLPTTLINSIFTEWLWGQFFCRLSTWANASTSFASVYTL 123

  Fly   155 TSIAIDRYFVIIYPFHPRMKLSTCIG------IIVSIWVIALLATVPYGMYMKMTNELVNGTQTG 213
            .::..|||..|.:    .:|.:|...      :|.::|::|.:..:| ..|
 Worm   124 VAVTADRYLAICH----TLKYNTSWDREYTKYVIFAVWLVAAIFGIP-NWY-------------- 169

  Fly   214 NETLVEATLMLNGSFVAQGSGFIEAPDSTSATQAYMQVMTAGSTGPEMPYVRVYCEENWPSEQYR 278
            |..|:                                |...||.|..:      |......:.|
 Worm   170 NYDLI--------------------------------VWQEGSYGYRL------CTSQTDQKLY- 195

  Fly   279 KVFGAITTTLQFVLPFFIISICY--VWISVKLNQR----ARAKPGSKSSRREEADRDR-KKRTNR 336
              |..:...|.|::||.:||..|  ::|:|..::.    |||:            .|| |.|...
 Worm   196 --FLFVNLLLAFIVPFGLISGLYTRIFITVSTHRSLAVDARAR------------EDRVKLRVAT 246

  Fly   337 MLIAMVAVFGLSWLPINVVNIFDDFDDKSNEWRFYILFFFVAHS------------------IAM 383
            |::.::.||...|||:..:               :..|||.|..                  :::
 Worm   247 MMLTVIIVFACCWLPLYCI---------------FTYFFFFADQRSDLFQITSMLIRPIFQWMSL 296

  Fly   384 SSTCYNPFLYAWLNENFRKEFKHVL--PCFNPSNNNIINITRGYNRSDRNTCGPRL-HHGKGDGG 445
            .|:..||.:|...:..:|:.||.:|  ||..........|.|.::|..::|....: :.|.....
 Worm   297 LSSSLNPIIYIAYSHKYRRAFKSILLMPCKTRYERVRSTILRRHSRGFKSTATISMSNFGTEPTN 361

  Fly   446 MGGGS 450
            :||.|
 Worm   362 LGGAS 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sNPF-R	NP_524176.1	7tmA_NPYR-like	64..404	CDD:320331	77/370 (21%)
		TM helix 1	65..91	CDD:320331	10/25 (40%)
		TM helix 2	98..123	CDD:320331	8/24 (33%)
		TM helix 3	136..166	CDD:320331	9/29 (31%)
		TM helix 4	177..198	CDD:320331	5/26 (19%)
		TM helix 5	278..307	CDD:320331	9/30 (30%)
		TM helix 6	329..359	CDD:320331	10/30 (33%)
		TM helix 7	372..397	CDD:320331	8/42 (19%)
npr-35	NP_001023088.2	7tm_GPCRs	33..317	CDD:475119	77/370 (21%)
		TM helix 1	35..59	CDD:410628	10/23 (43%)
		TM helix 2	68..90	CDD:410628	6/21 (29%)
		TM helix 3	106..128	CDD:410628	5/21 (24%)
		TM helix 4	151..167	CDD:410628	4/16 (25%)
		TM helix 5	194..217	CDD:410628	8/25 (32%)
		TM helix 6	245..267	CDD:410628	6/36 (17%)
		TM helix 7	285..310	CDD:410628	4/24 (17%)