DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sNPF-R and npr-3

DIOPT Version :9

Sequence 1:	NP_001262086.1	Gene:	sNPF-R / 40195	FlyBaseID:	FBgn0036934	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_502162.1	Gene:	npr-3 / 182494	WormBaseID:	WBGene00007006	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	352	Identity:	106/352 - (30%)
Similarity:	156/352 - (44%)	Gaps:	67/352 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 NQFVQIFFYVLYATVFVLGVFGNVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVPFTPLY 123
            || ::..|.:||..|:|..:.||.||.||:..|:...:|..:|:..||.||:|:|:.::|.|.:.
Worm    22 NQ-IRAIFSLLYLLVWVGAIVGNTLVLYVLTFNQVSLSVRTVFVGCLAGSDLLMCLFSLPITAIS 85

  Fly   124 TFMGRWAFGRSLCHLVSFAQGCSIYISTLTLTSIAIDRYFVIIYPFHPRMKLSTCIGIIVSIWVI 188
            .|...|.|....|.|:...||.:|::|:.|||.||:||..:|:.|....:.....:.|:..||::
Worm    86 IFSRVWVFPAIFCKLIGVFQGGTIFVSSFTLTVIALDRCVLILRPNQEIVNFPRAVFIVFCIWLL 150

  Fly   189 ALLATVPYGMYMKMTNELVNGTQTGNETLVEATLMLNGSFVAQGSGFIEAPDSTSATQAYMQVMT 253
            .....:|.|:|..                                  |...|....|
Worm   151 GYSLALPVGIYSD----------------------------------IAVYDEICGT-------- 173

  Fly   254 AGSTGPEMPYVRVYCEENWPS-------EQYRKVFGAITTTLQFVLPFFIISICYVWIS-VKLNQ 310
                         :||||||.       ...|:.:|.....|||.:|..|.||||..|| |..:|
Worm   174 -------------FCEENWPDFNPDTGRSGIRRAYGLSVLVLQFGIPALISSICYWMISRVMSDQ 225

  Fly   311 RARAKPGSKSSRREEADRDRKKRTNRMLIAMVAVFGLSWLPINVVNIFDDFDDKSNEWRFYILFF 375
            .||.:..:.....|....:||.|.|||:|.||..|.|:|:|.|.||::.|....|   ::|...|
Worm   226 LARRRGHNIRPESETKLVNRKTRANRMMIVMVVGFVLAWMPFNAVNLYRDLFGIS---KWYSTVF 287

  Fly   376 FVAHSIAMSSTCYNPFLYAWLNENFRK 402
            .:.|..||.|...||.:|:|.|..||:
Worm   288 ALCHVCAMCSAVLNPIIYSWFNPQFRQ 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sNPF-R	NP_001262086.1	7tm_4	75..>196	CDD:304433	39/120 (33%)
sNPF-R	NP_001262086.1	7tm_1	80..393	CDD:278431	94/320 (29%)
npr-3	NP_502162.1	7tmA_NPYR-like	26..314	CDD:320331	103/345 (30%)
		TM helix 1	28..52	CDD:320331	11/23 (48%)
		TM helix 2	61..83	CDD:320331	8/21 (38%)
		TM helix 3	99..121	CDD:320331	9/21 (43%)
		TM helix 4	142..158	CDD:320331	3/15 (20%)
		TM helix 5	193..216	CDD:320331	9/22 (41%)
		TM helix 6	247..272	CDD:320331	13/24 (54%)
		TM helix 7	284..309	CDD:320331	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1072979at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102619
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750