Protein Alignment sNPF-R and PROKR2

DIOPT Version :10

• Sequence 1: NP_524176.1
• Gene: sNPF-R / 40195
• FlyBaseID: FBgn0036934
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_658986.1
• Gene: PROKR2 / 128674
• HGNCID: 15836
• Length: 384
• Species: Homo sapiens
• Alignment Length: 359
• Identity: 89/359 - (24%)
• Similarity: 159/359 - (44%)
• Gaps: 80/359 - (22%)

  Fly    70 YATVFVLGV--FGNVLVCYV--------VLRNRAMQTVTNIFITNLALSDILLCVLAVPFTPLYT 124
            :|...|:|:  .|.:|||.:        :.|.:.::.:||:.|.|||:||.|:.::..||...|.
Human    50 FAAKIVIGIALAGIMLVCGIGNFVFIAALTRYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYY 114

  Fly   125 FMGR--WAFGRSLCHLVSFAQGCSIYISTLTLTSIAIDRYFVIIYPFHPRMKLSTCIGIIVSIWV 187
            .:.:  |..|..||..|::.:..|:|:||..|.:||||||..|::|..|||...|...:|..:|:
Human   115 VVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWM 179

  Fly   188 IALLATVPYGMYMKMTNELVNGTQTGNETLVEATLMLNGSFVAQGSGFIEAPDSTSATQAYMQVM 252
            :::|..:|...:                                            ||:..:.::
Human   180 VSILIAIPSAYF--------------------------------------------ATETVLFIV 200

  Fly   253 TAGSTGPEMPYVRVYCEENWPSEQ--YRKVFGAITTTLQFVLPFFIISICYVWISVKLNQRARAK 315
            .:..        :::|.:.||.:|  |.|.:......::||.|...:::||..||.:|  ..:|.
Human   201 KSQE--------KIFCGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCYARISREL--WFKAV 255

  Fly   316 PGSKSSRREEADRDRKKRTNRMLIAMVAVFGLSWLPINVVNIFDDF------DDKSNEWRFYILF 374
            ||.::.:..:..|.|:| |..:|:.::..:.|.|.|.....|..||      .:|     .|:..
Human   256 PGFQTEQIRKRLRCRRK-TVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEK-----HYLTA 314

  Fly   375 FFVAHSIAMSSTCYNPFLYAWLNENFRKEFKHVL 408
            |:|...||||::..|...:..:..|..|.||.::
Human   315 FYVVECIAMSNSMINTVCFVTVKNNTMKYFKKMM 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sNPF-R	NP_524176.1	7tmA_NPYR-like	64..404	CDD:320331	87/353 (25%)
		TM helix 1	65..91	CDD:320331	7/30 (23%)
		TM helix 2	98..123	CDD:320331	11/24 (46%)
		TM helix 3	136..166	CDD:320331	13/29 (45%)
		TM helix 4	177..198	CDD:320331	5/20 (25%)
		TM helix 5	278..307	CDD:320331	8/28 (29%)
		TM helix 6	329..359	CDD:320331	8/29 (28%)
		TM helix 7	372..397	CDD:320331	7/24 (29%)
PROKR2	NP_658986.1	7tmA_prokineticin-R	54..344	CDD:320332	86/349 (25%)
		TM helix 1	55..81	CDD:320332	6/25 (24%)
		TM helix 2	88..113	CDD:320332	11/24 (46%)
		TM helix 3	128..158	CDD:320332	13/29 (45%)
		TM helix 4	169..190	CDD:320332	5/20 (25%)
		TM helix 5	220..249	CDD:320332	8/28 (29%)
		TM helix 6	268..298	CDD:320332	9/30 (30%)
		TM helix 7	312..337	CDD:320332	7/24 (29%)