Protein Alignment sNPF-R and CHRM4

DIOPT Version :9

• Sequence 1: NP_001262086.1
• Gene: sNPF-R / 40195
• FlyBaseID: FBgn0036934
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_000732.2
• Gene: CHRM4 / 1132
• HGNCID: 1953
• Length: 479
• Species: Homo sapiens
• Alignment Length: 475
• Identity: 95/475 - (20%)
• Similarity: 172/475 - (36%)
• Gaps: 150/475 - (31%)

  Fly    58 HNQF---VQIFFYVLYATVFVLGVFGNVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVPF 119
            ||::   ..:|...:..::.::.|.||:||...:..||.:|||.|.|:.:||.:|:::...::..
Human    24 HNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNL 88

  Fly   120 TPLYTFMGRWAFGRSLC-------HLVSFAQGCSIYISTLTLTSIAIDRYFVIIYPF-HPRMKLS 176
            ..:|...|.|..|..:|       ::||.|       |.:.|..|:.||||.:..|. :|..:.:
Human    89 YTVYIIKGYWPLGAVVCDLWLALDYVVSNA-------SVMNLLIISFDRYFCVTKPLTYPARRTT 146

  Fly   177 TCIGI-IVSIWVIALLATVPYGMYMKMTNELVNGTQT--GNETLVE------------------- 219
            ...|: |.:.||::.:...|..::.    :.|.|.:|  .|:..::
Human   147 KMAGLMIAAAWVLSFVLWAPAILFW----QFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLP 207

  Fly   220 ----ATLMLNGSFV-----------------AQGSGFIEAP------------------------ 239
                ..|.::.|..                 |:...|:::|
Human   208 VVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKL 272

  Fly   240 ------------------------DSTSATQ-----AYMQVMTAGSTGPEMPYVRVYCEENWPSE 275
                                    .|.||||     ...::.|..:|.|.||...:......|:.
Human   273 EEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPAS 337

  Fly   276 QYRKV------FGAITTTLQFVLPFF------IISICYVWISVKLNQRARAKPGSKSSRREEADR 328
            ::.|:      .|....|...::|..      ..::...:.|:..||..:        :|:.|.|
Human   338 RWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRK--------KRQMAAR 394

  Fly   329 DRKKRTNRMLIAMVAVFGLSWLPINV---VNIFDDFDDKSNEWRFYILFFFVAHSIAMSSTCYNP 390
            :||  ..|.:.|::..|.|:|.|.||   ||.|.........|.       :.:.:...::..||
Human   395 ERK--VTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWS-------IGYWLCYVNSTINP 450

  Fly   391 FLYAWLNENFRKEFKHVLPC 410
            ..||..|..|:|.|:|:|.|
Human   451 ACYALCNATFKKTFRHLLLC 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sNPF-R	NP_001262086.1	7tm_4	75..>196	CDD:304433	36/129 (28%)
		7tm_1	80..393	CDD:278431	82/431 (19%)
CHRM4	NP_000732.2	7tmA_mAChR_M4	33..464	CDD:341344	89/458 (19%)
		TM helix 1	35..59	CDD:341344	5/23 (22%)
		TM helix 2	68..90	CDD:341344	5/21 (24%)
		TM helix 3	106..128	CDD:341344	6/28 (21%)
		TM helix 4	151..167	CDD:341344	3/15 (20%)
		TM helix 5	193..216	CDD:341344	1/22 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..333		10/61 (16%)
		TM helix 6	399..421	CDD:341344	8/21 (38%)
		TM helix 7	432..457	CDD:341344	5/31 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910