DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sNPF-R and npy2r

DIOPT Version :9

Sequence 1:	NP_001262086.1	Gene:	sNPF-R / 40195	FlyBaseID:	FBgn0036934	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	XP_004911210.1	Gene:	npy2r / 100498351	XenbaseID:	XB-GENE-983413	Length:	408	Species:	Xenopus tropicalis

Alignment Length:	393	Identity:	118/393 - (30%)
Similarity:	185/393 - (47%)	Gaps:	79/393 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 VQIFFYVLYATVFVLGVFGNVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVPFTPLYTFM 126
            ||:...:.|:::.:|||.||.||.|||::.:.|:||||.||.|||:||:::..|.:|||.:||.:
Frog    72 VQVVLILAYSSIILLGVLGNSLVIYVVIKFKTMRTVTNFFIVNLAVSDLMVNTLCLPFTLVYTLL 136

  Fly   127 GRWAFGRSLCHLVSFAQGCSIYISTLTLTSIAIDRYFVIIYPFHPRMKLST--CIGIIVSIWVIA 189
            ..|.||..|||||:::||.::.:||:||..||:||:..|:|  |...|:||  |..||...||.:
Frog   137 DDWKFGTVLCHLVTYSQGLAVQVSTVTLMVIALDRHRCIVY--HLESKISTKICFMIIGITWVCS 199

  Fly   190 LLATVPYGMYMKMTNELVNGTQTGNETLVEATLMLNGSFVAQGSGFIEAPDSTSATQAYMQVMTA 254
            .|...|..::.:.                 :.::::..|..|.
Frog   200 ALLASPLAIFKEY-----------------SVIVISSDFQIQA---------------------- 225

  Fly   255 GSTGPEMPYVRVYCEENWP--SEQYRKVFGAITTTLQFVLPFFIISICYVWISVKLNQRARAKPG 317
                         |.|.||  ...|..::......:|:::|..|||..|:.|..||  :....||
Frog   226 -------------CSERWPVGDLNYGTIYSISMLLIQYIVPLAIISYAYIRIWTKL--KNHVSPG 275

  Fly   318 SKSSRREEADRDRKKRTNRMLIAMVAVFGLSWLPINVVNIFDDFDDKSNEWRFYILFFFVAHSIA 382
            ..:....:    |:::|.:||:|:|.||.:.|||.:...:..|.|.|..:...|.|.:.:.|.||
Frog   276 GGNDHYHQ----RRRKTTKMLVAVVVVFAVCWLPFHAFQLASDIDGKVLDLNEYKLIYTIFHVIA 336

  Fly   383 MSSTCYNPFLYAWLNENFRKEFKHVLPC------FNPSNNNIINITR---------GYNRSDRNT 432
            |.||..||.||.|:|.|:|..|.....|      .:|..:..|.:.:         |.:.:...|
Frog   337 MCSTFANPLLYGWMNNNYRTAFLTAFKCEQRMDSIHPEVSVAIQLKKKQLEVKEINGTSDNSHGT 401

  Fly   433 CGP 435
            |.|
Frog   402 CTP 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sNPF-R	NP_001262086.1	7tm_4	75..>196	CDD:304433	58/122 (48%)
sNPF-R	NP_001262086.1	7tm_1	80..393	CDD:278431	98/316 (31%)
npy2r	XP_004911210.1	7tmA_NPY2R	74..358	CDD:320521	108/343 (31%)
		TM helix 1	75..101	CDD:320521	11/25 (44%)
		TM helix 2	108..133	CDD:320521	13/24 (54%)
		TM helix 3	146..176	CDD:320521	14/29 (48%)
		TM helix 4	187..208	CDD:320521	7/20 (35%)
		TM helix 5	238..267	CDD:320521	7/28 (25%)
		TM helix 6	283..313	CDD:320521	11/33 (33%)
		TM helix 7	326..351	CDD:320521	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X589
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010