DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sNPF-R and npy2r

DIOPT Version :9

Sequence 1:	NP_001262086.1	Gene:	sNPF-R / 40195	FlyBaseID:	FBgn0036934	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	XP_001343301.3	Gene:	npy2r / 100003852	ZFINID:	ZDB-GENE-040924-8	Length:	379	Species:	Danio rerio

Alignment Length:	432	Identity:	132/432 - (30%)
Similarity:	195/432 - (45%)	Gaps:	71/432 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TITTTSSSISTSQLPLVSTTNWSLTSPGTTSAILADVAASDEDRSGGIIHNQFVQIFFYVLYATV 73
            |...||...:.|||.  .:||..........|.|.| ...|..:..|      ||:...:.|:|:
Zfish     5 TQINTSEDGTLSQLN--QSTNCCAPDTAEVDAALLD-GLEDSTKLVG------VQVILILAYSTI 60

  Fly    74 FVLGVFGNVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVPFTPLYTFMGRWAFGRSLCHL 138
            ...|:.||.||.|||.:.|.:.||||.||.|||::|:|:..|.:|||.:||..|.|.||:.:|:|
Zfish    61 IFFGMTGNSLVIYVVYKFRNLHTVTNYFIVNLAVADLLVNTLCLPFTLMYTLYGEWKFGQVMCYL 125

  Fly   139 VSFAQGCSIYISTLTLTSIAIDRYFVIIYPFHPRMKLSTCIGIIVSIWVIALLATVPYGMYMKMT 203
            :.:|||.::::||:||..||:|||..|:|....:|....|:.:|...||.:.:...|..::
Zfish   126 LPYAQGLAVHVSTITLNVIALDRYRSIVYHMETKMSKDMCVVVIAITWVASAILASPLAIF---- 186

  Fly   204 NELVNGTQTGNETLVEATLMLNGSFVAQGSGFIEAPDSTSATQAYMQVMTAGSTGPEMPYVRVYC 268
            .|.|....:..:|:             ||                                   |
Zfish   187 REYVTFDLSPEQTI-------------QG-----------------------------------C 203

  Fly   269 EENWP-SEQYRKVFGAITTTLQFVLPFFIISICYVWISVKLNQRARAKPGSKSSRREEADRDRKK 332
            .|.|| |.....::......||:.||..|||..|..|..||  |....||...|.|.:    |::
Zfish   204 AEKWPGSSTDGTIYSIAMFFLQYGLPLSIISFAYTRIWNKL--RNHVSPGGGRSDRHQ----RRQ 262

  Fly   333 RTNRMLIAMVAVFGLSWLPINVVNIFDDFDDKSNEWRFYILFFFVAHSIAMSSTCYNPFLYAWLN 397
            :|.:||:|:|.||.:||||.:...:..|.|....|.:.:.|.:...|.:||.||..||.||.|:|
Zfish   263 KTTKMLVAVVVVFTVSWLPFHAFQLAVDIDSSVLEMKDFKLLYTAFHIVAMCSTFANPILYGWMN 327

  Fly   398 ENFRKEFKHVLPCFNPSNNNIINITRGYNRSDRNTCGPRLHH 439
            .|:|..|..|..| ...||.:..::.  :.:.|..|...|.:
Zfish   328 RNYRGSFVAVFKC-GRINNGMRRVSS--SEAVREKCTRNLEN 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sNPF-R	NP_001262086.1	7tm_4	75..>196	CDD:304433	51/120 (43%)
sNPF-R	NP_001262086.1	7tm_1	80..393	CDD:278431	100/313 (32%)
npy2r	XP_001343301.3	7tm_GPCRs	51..334	CDD:333717	109/340 (32%)
		TM helix 1	53..77	CDD:320095	10/23 (43%)
		TM helix 2	86..108	CDD:320095	11/21 (52%)
		TM helix 3	124..146	CDD:320095	9/21 (43%)
		TM helix 4	167..183	CDD:320095	3/15 (20%)
		TM helix 5	215..238	CDD:320095	7/22 (32%)
		TM helix 6	262..287	CDD:320095	11/24 (46%)
		TM helix 7	302..327	CDD:320095	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	192	1.000	Inparanoid score	I3847
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102619
Panther	1	1.100	-	-	O	PTHR24235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.960