DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sNPF-R and gpr83

DIOPT Version :9

Sequence 1:	NP_001262086.1	Gene:	sNPF-R / 40195	FlyBaseID:	FBgn0036934	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	XP_001342488.2	Gene:	gpr83 / 100002786	ZFINID:	ZDB-GENE-060526-286	Length:	351	Species:	Danio rerio

Alignment Length:	389	Identity:	127/389 - (32%)
Similarity:	192/389 - (49%)	Gaps:	84/389 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NWSLTSPGTTSAILADVAASDEDRSGGIIHNQFVQIFFYVLYATVFVLGVFGNVLVCYVVLRNRA 93
            |:||.|       :.|..::.|..|    |...::....|.|:.:.::.:||||:||:||::|:.
Zfish    25 NFSLDS-------MYDRGSNYESES----HRPTIRALLIVAYSVIIIISLFGNVVVCHVVIKNKR 78

  Fly    94 MQTVTNIFITNLALSDILLCVLAVPFTPLYTFMGRWAFGRSLCHLVSFAQGCSIYISTLTLTSIA 158
            |.:||::||.|||::|||:.:|..|||.:......|.||:.:||:..|||.||:::|.|||.:||
Zfish    79 MHSVTSLFIMNLAIADILITLLNTPFTLVRFVYSTWVFGKVMCHVSRFAQYCSVHVSVLTLVAIA 143

  Fly   159 IDRYFVIIYPFHPRMKLSTCIGIIVSIWVIALLATVPYGMYMKMTNELVNGTQTGNETLVEATLM 223
            |||:.|:::|...||.....|..|..|||:....::|:.:|.|:..     .:.||..
Zfish   144 IDRHQVVMHPMKQRMSRLQGIAWIGVIWVMGSCFSLPHAIYQKLLR-----FEFGNNR------- 196

  Fly   224 LNGSFVAQGSGFIEAPDSTSATQAYMQVMTAGSTGPEMPYVRVYCEENW-----PSEQYRKVFGA 283
                                                    ||:.|   |     ||:.:.|....
Zfish   197 ----------------------------------------VRMVC---WPSFPHPSDLFWKYLDL 218

  Fly   284 ITTTLQFVLPFFIISICYVWISVKL-NQRARAKPGSKSSRREEADRDRKKRTNRMLIAMVAVFGL 347
            .:..|.:|||..||||.|:.::.|: .|.|   .|..:..:..|.|.|||.|.:||||:||||.:
Zfish   219 ASFVLLYVLPLAIISISYLVVAKKVWFQNA---VGDVTLAQSAAQRRRKKTTLKMLIAVVAVFAV 280

  Fly   348 SWLPIN--VVNIFDDFDDKSNEWRFYILFFFVAHSIAMSSTCYNPFLYAWLNENFRKEFKHVLP 409
            .|.|:|  :|.:.......:|      ..:|..|.:||||||||||:|.|||.:||.|.: .||
Zfish   281 CWFPLNCYIVLLSSKVIQANN------AVYFTFHWLAMSSTCYNPFIYCWLNHSFRAELR-ALP 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sNPF-R	NP_001262086.1	7tm_4	75..>196	CDD:304433	52/120 (43%)
sNPF-R	NP_001262086.1	7tm_1	80..393	CDD:278431	107/320 (33%)
gpr83	XP_001342488.2	7tmA_GPR83	49..333	CDD:320511	116/347 (33%)
		TM helix 1	50..76	CDD:320511	10/25 (40%)
		TM helix 2	83..108	CDD:320511	13/24 (54%)
		TM helix 3	121..151	CDD:320511	17/29 (59%)
		TM helix 4	162..183	CDD:320511	6/20 (30%)
		TM helix 5	213..242	CDD:320511	10/28 (36%)
		TM helix 6	262..292	CDD:320511	16/29 (55%)
		TM helix 7	301..326	CDD:320511	15/30 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BIJ1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1072979at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3808
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940