Protein Alignment CG14183 and PEX1

DIOPT Version :10

• Sequence 1: NP_649172.3
• Gene: CG14183 / 40192
• FlyBaseID: FBgn0036931
• Length: 872
• Species: Drosophila melanogaster
• Sequence 2: NP_012724.1
• Gene: PEX1 / 853636
• SGDID: S000001680
• Length: 1043
• Species: Saccharomyces cerevisiae
• Alignment Length: 771
• Identity: 142/771 - (18%)
• Similarity: 267/771 - (34%)
• Gaps: 257/771 - (33%)

  Fly   186 KKKFLKVHQ-------RKKINYKF------TFKPDQ------------AMSIPVKRTIFSADFLK 225
            |.:||:::|       ...:|.|:      |...||            .:.:|.::.|..   :|
Yeast   311 KLEFLQMNQANIISGRNATVNIKYFGKDVPTKSGDQYSKLLGGSLLTNNLILPTEQIIIE---IK 372

  Fly   226 ADESCENLIKKDDVAD-------TAIDDEEALSAIQNNAACKIQSCWRGYKTRKIVKIRKRFKEE 283
            ..||.:.|...:::::       |.:..||....|:.:..       :.|..::..::.:..|:|
Yeast   373 KGESEQQLCNLNEISNESVQWKVTQMGKEEVKDIIERHLP-------KHYHVKETGEVSRTSKDE 430

  Fly   284 -----LYGMKK--IRKLKRPNQTANSIMEMYKNEMLKKKLDEDFINLINDERTRLLQFRSPWMME 341
                 :..:||  :..|..|.....:|:...|..:.|.:|.::.||.:..:....:::.....:.
Yeast   431 DDFITVNSIKKEMVNYLTSPIIATPAIILDGKQGIGKTRLLKELINEVEKDHHIFVKYADCETLH 495

  Fly   342 DISD------HIRAW--FKEFYDATGNFHPYPDPVKQGTVLVVIDETMTPMEFQESLGKKPLSKA 398
            :.|:      .|..|  |..:|               |..|:|:|..       |:|..||
Yeast   496 ETSNLDKTQKLIMEWCSFCYWY---------------GPSLIVLDNV-------EALFGKP---- 534

  Fly   399 ELKKLRDKEKKEKRKKKEKLKQLKMKEAKRRKKLRDAGVIDIGYELTASKAIE-NIEETMKKYSK 462
                                            :..|....:.|....|||.:. .|.:..|.::|
Yeast   535 --------------------------------QANDGDPSNNGQWDNASKLLNFFINQVTKIFNK 567

  Fly   463 DWRNVDEYLNKNHDPIKEWVTEEQLAKIHQEVRGLVDEYMRVEYELLREALAKDNDEKYKALKVK 527
            |        ||.   |:...:.:|..:|:..   |.|::...|...||   |.|...:.|.|:..
Yeast   568 D--------NKR---IRVLFSGKQKTQINPL---LFDKHFVSETWSLR---APDKHARAKLLEYF 615

  Fly   528 YPKKKKEKRKKKPKDMT-GDRTLES-----LYNELKDAGIIEEIG-HRDFDEFITDFNFVADDTR 585
            :   .|.:..|..:|:. .|.:||:     |..|:....|..::. .||.|..:|...|
Yeast   616 F---SKNQIMKLNRDLQFSDLSLETEGFSPLDLEIFTEKIFYDLQLERDCDNVVTRELF------ 671

  Fly   586 DEDGLTTLGPAK--------------GDI------KMVIQESMLGMGEFD---VPKP----KSLL 623
             ...|:...|:.              |||      |.|:.|::....:::   |..|    ..:|
Yeast   672 -SKSLSAFTPSALRGVKLTKETNIKWGDIGALANAKDVLLETLEWPTKYEPIFVNCPLRLRSGIL 735

  Fly   624 LIGPLNSGKRLLCEIIASELDAVFMNL-SPENTYKYAKDLKYFLHVILKVAKAFQPTIMYIEEAH 687
            |.|....||.||...:|.:....|::: .||...|:....:..:..:.:.|::.:|.|::.:|
Yeast   736 LYGYPGCGKTLLASAVAQQCGLNFISVKGPEILNKFIGASEQNIRELFERAQSVKPCILFFDE-- 798

  Fly   688 RLFWKKVPP----EAVEINPRLLGTSLA------------------------SKILKPLKKNDKI 724
               :..:.|    ::..:..|::...|.                        |.:|:| .:.||.
Yeast   799 ---FDSIAPKRGHDSTGVTDRVVNQLLTQMDGAEGLDGVYILAATSRPDLIDSALLRP-GRLDKS 859

  Fly   725 VLVGTSNMPWAA----------NGGIKRAFQKVLLIPK-CDYGTSFLLWLELMTENAPD----DM 774
            |:   .|:|..:          |...|...||...:.| .|        |:|:.|....    |:
Yeast   860 VI---CNIPTESERLDILQAIVNSKDKDTGQKKFALEKNAD--------LKLIAEKTAGFSGADL 913

  Fly   775 KEYAYSA-LARVLQAYNSGDIDDNVKETLNIDRKMRLKNEALDPNEFLEYFLSKNE 829
            :...|:| |..|.:..::.|                 ::|.:..|:.:||| |.||
Yeast   914 QGLCYNAYLKSVHRWLSAAD-----------------QSEVVPGNDNIEYF-SINE 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14183	NP_649172.3	Adgb_C_mid-like	<201..>278	CDD:412094	15/101 (15%)
		globin helix H	201..232	CDD:412094	9/48 (19%)
		IQCD	247..278	CDD:467745	4/30 (13%)
		IQ motif	259..277	CDD:412094	1/17 (6%)
		P-loop containing Nucleoside Triphosphate Hydrolases	617..750	CDD:476819	32/175 (18%)
PEX1	NP_012724.1	PEX-1N	108..183	CDD:462729
		CDC48	<401..1023	CDD:273521	126/678 (19%)
		RecA-like_PEX1_r2	705..862	CDD:410934	30/165 (18%)