DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14183 and PEX1

DIOPT Version :9

Sequence 1:	NP_649172.3	Gene:	CG14183 / 40192	FlyBaseID:	FBgn0036931	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_012724.1	Gene:	PEX1 / 853636	SGDID:	S000001680	Length:	1043	Species:	Saccharomyces cerevisiae

Alignment Length:	771	Identity:	142/771 - (18%)
Similarity:	267/771 - (34%)	Gaps:	257/771 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 KKKFLKVHQ-------RKKINYKF------TFKPDQ------------AMSIPVKRTIFSADFLK 225
            |.:||:::|       ...:|.|:      |...||            .:.:|.::.|..   :|
Yeast   311 KLEFLQMNQANIISGRNATVNIKYFGKDVPTKSGDQYSKLLGGSLLTNNLILPTEQIIIE---IK 372

  Fly   226 ADESCENLIKKDDVAD-------TAIDDEEALSAIQNNAACKIQSCWRGYKTRKIVKIRKRFKEE 283
            ..||.:.|...:::::       |.:..||....|:.:..       :.|..::..::.:..|:|
Yeast   373 KGESEQQLCNLNEISNESVQWKVTQMGKEEVKDIIERHLP-------KHYHVKETGEVSRTSKDE 430

  Fly   284 -----LYGMKK--IRKLKRPNQTANSIMEMYKNEMLKKKLDEDFINLINDERTRLLQFRSPWMME 341
                 :..:||  :..|..|.....:|:...|..:.|.:|.::.||.:..:....:::.....:.
Yeast   431 DDFITVNSIKKEMVNYLTSPIIATPAIILDGKQGIGKTRLLKELINEVEKDHHIFVKYADCETLH 495

  Fly   342 DISD------HIRAW--FKEFYDATGNFHPYPDPVKQGTVLVVIDETMTPMEFQESLGKKPLSKA 398
            :.|:      .|..|  |..:|               |..|:|:|..       |:|..||
Yeast   496 ETSNLDKTQKLIMEWCSFCYWY---------------GPSLIVLDNV-------EALFGKP---- 534

  Fly   399 ELKKLRDKEKKEKRKKKEKLKQLKMKEAKRRKKLRDAGVIDIGYELTASKAIE-NIEETMKKYSK 462
                                            :..|....:.|....|||.:. .|.:..|.::|
Yeast   535 --------------------------------QANDGDPSNNGQWDNASKLLNFFINQVTKIFNK 567

  Fly   463 DWRNVDEYLNKNHDPIKEWVTEEQLAKIHQEVRGLVDEYMRVEYELLREALAKDNDEKYKALKVK 527
            |        ||.   |:...:.:|..:|:..   |.|::...|...||   |.|...:.|.|:..
Yeast   568 D--------NKR---IRVLFSGKQKTQINPL---LFDKHFVSETWSLR---APDKHARAKLLEYF 615

  Fly   528 YPKKKKEKRKKKPKDMT-GDRTLES-----LYNELKDAGIIEEIG-HRDFDEFITDFNFVADDTR 585
            :   .|.:..|..:|:. .|.:||:     |..|:....|..::. .||.|..:|...|
Yeast   616 F---SKNQIMKLNRDLQFSDLSLETEGFSPLDLEIFTEKIFYDLQLERDCDNVVTRELF------ 671

  Fly   586 DEDGLTTLGPAK--------------GDI------KMVIQESMLGMGEFD---VPKP----KSLL 623
             ...|:...|:.              |||      |.|:.|::....:::   |..|    ..:|
Yeast   672 -SKSLSAFTPSALRGVKLTKETNIKWGDIGALANAKDVLLETLEWPTKYEPIFVNCPLRLRSGIL 735

  Fly   624 LIGPLNSGKRLLCEIIASELDAVFMNL-SPENTYKYAKDLKYFLHVILKVAKAFQPTIMYIEEAH 687
            |.|....||.||...:|.:....|::: .||...|:....:..:..:.:.|::.:|.|::.:|
Yeast   736 LYGYPGCGKTLLASAVAQQCGLNFISVKGPEILNKFIGASEQNIRELFERAQSVKPCILFFDE-- 798

  Fly   688 RLFWKKVPP----EAVEINPRLLGTSLA------------------------SKILKPLKKNDKI 724
               :..:.|    ::..:..|::...|.                        |.:|:| .:.||.
Yeast   799 ---FDSIAPKRGHDSTGVTDRVVNQLLTQMDGAEGLDGVYILAATSRPDLIDSALLRP-GRLDKS 859

  Fly   725 VLVGTSNMPWAA----------NGGIKRAFQKVLLIPK-CDYGTSFLLWLELMTENAPD----DM 774
            |:   .|:|..:          |...|...||...:.| .|        |:|:.|....    |:
Yeast   860 VI---CNIPTESERLDILQAIVNSKDKDTGQKKFALEKNAD--------LKLIAEKTAGFSGADL 913

  Fly   775 KEYAYSA-LARVLQAYNSGDIDDNVKETLNIDRKMRLKNEALDPNEFLEYFLSKNE 829
            :...|:| |..|.:..::.|                 ::|.:..|:.:||| |.||
Yeast   914 QGLCYNAYLKSVHRWLSAAD-----------------QSEVVPGNDNIEYF-SINE 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14183	NP_649172.3	AAA	622..751	CDD:278434	31/167 (19%)
PEX1	NP_012724.1	PEX-1N	108..183	CDD:401267
		SpoVK	457..929	CDD:223540	107/573 (19%)
		RecA-like_PEX1_r2	705..862	CDD:410934	30/165 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900