DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14183 and IQCA1

DIOPT Version :9

Sequence 1:	NP_649172.3	Gene:	CG14183 / 40192	FlyBaseID:	FBgn0036931	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_001257514.1	Gene:	IQCA1 / 79781	HGNCID:	26195	Length:	830	Species:	Homo sapiens

Alignment Length:	912	Identity:	257/912 - (28%)
Similarity:	438/912 - (48%)	Gaps:	146/912 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 HKFWVYTRKEIGKLIKKQNRLKKIEPPEEKAVSYKIYAELYVLYVELVNKLSFIYHNTFQVQKRA 71
            :|.|..|::.:|.|:.|:.: |.|||...:...::..|..||.||::...|..:|......|||.
Human    14 NKMWHQTQEALGALLDKEPQ-KMIEPQRNQVFIFQTLATFYVKYVQIFRNLENVYDQFVHPQKRI 77

  Fly    72 LVRVLVENATQQLMQLKEELKDLEMSEYIYIDKALIARKLTPRDLVVWRSPQFLYRRPLDI---- 132
            |:|.:::....::::||.|:.:||::|:.|.|..|...||.|:.|.: ..|::..:..|::
Human    78 LIRKVLDGVMGRILELKNEMVELELTEFHYFDDILQDLKLAPQQLDI-PIPKYFLKEKLEVIKGR 141

  Fly   133 ----QNIIADNRLYMNDEEKEEKAAQDWVPISEAVKLIQAHERARRARVYKSNIKYDKKKFLKVH 193
                ..|:||:.:..:|.:...|:    :|..|||||||..||||:.|:   ...:.|:.:|:.:
Human   142 EKILAQILADSGIDTSDMKYPVKS----IPFDEAVKLIQIAERARQGRL---RALFMKQIYLQEY 199

  Fly   194 QRKKINYKFTFKPDQAMSIPVKRTIFSADFLKADESCENLIKKDDVADTAIDDEEALSAIQNNAA 258
            :.|:                                .:.|.||  |.||..            ||
Human   200 RAKQ--------------------------------SKMLGKK--VTDTWA------------AA 218

  Fly   259 CKIQSCWRGYKTRKIVKIRKRFKEEL--YGMKKIRKLKRP---NQTANSIMEMYKNEMLKK---- 314
            .:||..||.:..||  :..|..:||:  .||..      |   |:.:.::::..|.:.|:.
Human   219 LRIQKVWRRFHQRK--ETEKLREEEMIFLGMNP------PPLFNEVSATVIQAEKVDRLRNEVQI 275

  Fly   315 KLDEDFINLINDERTRLLQFRSPWMMEDISDHIRAWFKEFYDATGNFHPYPDPVKQGTVLVVIDE 379
            |.:||:...:...:..|.......:.|::.|.||.||.|..:.||.|..|||..:.|:.::..|:
Human   276 KHEEDYREALVTIKNDLKLIEGVDIKENLQDQIRHWFIECRNLTGTFPDYPDVEEGGSAIIFSDK 340

  Fly   380 TMTPMEFQESLGKKPLSKAELKKLRDKEKKEKRKKKEKLKQLKMKEAKRRKKLRDAGV------I 438
            |:  .:..|.:            :.::|::||.|||:|.|:.:.|:||::||    |.      .
Human   341 TI--QQVIEDI------------IANQEEEEKNKKKKKKKEKQPKKAKKQKK----GTKEKNKEE 387

  Fly   439 DIGYELTASKAIENIEETMKKYSKDWRNVDEYLNKNHDPIKEWVTEEQLAKIHQEVRGLVDEYMR 503
            |..::::.|..:..::|....|.:.|...||..|.:.|...|.:.||:..::..|:|..|||.||
Human   388 DEKWKMSPSLFLPAMKEGCNAYKEIWMKKDESWNFSQDYDPELIKEEKRKELQSEIRIQVDELMR 452

  Fly   504 VEYELLREALAKDNDEKYKALKVKYPK-----KKKEKRKKKPKDMTGDRTLESLYNELKDAGIIE 563
            .|.:.|:.|:.::.:...||.|.|..|     |||||:.||.||:|.|||:||||.||.:.|::.
Human   453 QELKNLKLAVDRERERPVKAGKKKDKKKGKKGKKKEKKAKKDKDLTADRTIESLYKELVEEGLLI 517

  Fly   564 EIGHRDFDEFITDFNFVADDTRDEDGLTTLG-------PAKGDIKMVIQESMLG---MGEFDV-- 616
            :....:..::|.:::::.         |||.       |:..|::.:|  ::.|   :|...|
Human   518 QALKVNLSDYIGEYSYLG---------TTLRQVSIEPMPSLLDVRQLI--TLYGIWPLGSAAVHE 571

  Fly   617 --PKPKSLLLIGPLNSGKRLLCEIIASELDAVFMNLSPEN---TYKYAKDLKYFLHVILKVAKAF 676
              |..|||||.||...||::|...|.:|..|...|||..|   .|.....|:..||.:.|||:..
Human   572 KAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNGLQMMLHAVFKVARQL 636

  Fly   677 QPTIMYIEEAHRLFWKKVPPEAVEIN-PRLLGTSLASKILKPLKKNDKIVLVGTSNMPWAAN-GG 739
            ||::::||:..:.|:||| |.|.::| |:.|...| .:|||.||.:|:|::|||:..|:.|. ..
Human   637 QPSVVWIEDTEKTFYKKV-PNAEKMNEPKRLKKHL-PQILKLLKPDDRILIVGTTRRPFDAELQS 699

  Fly   740 IKRAFQKVLLIPKCDYGTSFLLWLELMTENAPDDMKEYAYSALARVLQAYNSGDIDDNVKETLNI 804
            ..:.:||::|:|:.||.:.::||.:::..|..........|.||:|...:..|.|.:.||..|..
Human   700 FCKVYQKIILVPRPDYASRYVLWKQIIERNGGVLTSALNVSCLAKVTDGFTQGHIVEVVKGVLTD 764

  Fly   805 DRKMRLKNEALDPNEFLEYFLSKNEPPIFPPDEKIMDKFNKWFGSSNKLEKLRKSYMAQKLAKAS 869
            .|..|..::.|...||:....|.|  |::..:|   :.|..|:..:...:|...:.......||.
Human   765 QRIRRQIHKPLTAVEFITAITSMN--PVYKEEE---ESFKNWYAKTPLGKKRALAITGGSTEKAK 824

  Fly   870 KK 871
            .|
Human   825 DK 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14183	NP_649172.3	AAA	622..751	CDD:278434	51/133 (38%)
IQCA1	NP_001257514.1	SpoVK	<497..796	CDD:223540	99/316 (31%)
IQCA1	NP_001257514.1	AAA	579..712	CDD:278434	51/134 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145393
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7744
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D127946at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103079
Panther	1	1.100	-	-	O	PTHR14690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.660