Protein Alignment CG14183 and Nvl

DIOPT Version :9

• Sequence 1: NP_649172.3
• Gene: CG14183 / 40192
• FlyBaseID: FBgn0036931
• Length: 872
• Species: Drosophila melanogaster
• Sequence 2: NP_080447.1
• Gene: Nvl / 67459
• MGIID: 1914709
• Length: 855
• Species: Mus musculus
• Alignment Length: 483
• Identity: 94/483 - (19%)
• Similarity: 182/483 - (37%)
• Gaps: 137/483 - (28%)

  Fly   398 AELKKLRDKEKKEKRKKKEKLKQLKM-------KEAKRRKKLRDAGVIDIGYELTASKAIENIE- 454
            ::|::|...:...:::...:::..|:       ||.|..|:|.|..:        |.:|.::.|
Mouse    37 SDLQRLYSVDYGRRKRNAFRIQVEKVFSIISSEKELKNLKELEDGHL--------AKRARQDEED 93

  Fly   455 ETMKKYSKDWRNVDEYLNKNHDPIKEWVTEEQLAKIHQEVRGLVDEYMRVEYELLREALAKDN-- 517
            |..:.||.|..|:::|    .||.........|..:::  ||..:..........|||.....
Mouse    94 EYTESYSDDDSNMEDY----PDPQSANPMNSSLLSLYR--RGNSESVSTTPKWGQREATTSTPLL 152

  Fly   518 DEKYKALKVKYPKKKKE-----------KRKKKPKDMTGDRT----LESLYNELKDAGIIEE--- 564
            ..|..::.:|.|.::.|           |::..|.|::.|::    .:|....|||:.::|.
Mouse   153 TSKTGSVPLKTPARESEGGWFIDKTPGGKKESLPLDLSDDQSNSKKQDSEIQILKDSSLLESDKK 217

  Fly   565 -------IGHRDFDEFITDF----------------------NFVADDTRDEDGLTTLGPAKGDI 600
                   .|::...|.:.:.                      |...:|....|  .||   |...
Mouse   218 RKGRAKGKGNKRKTENLQEVDGEIEALLQKKAKARSTELQISNVKFEDVGGND--ATL---KEVC 277

  Fly   601 KMVIQ----ESMLGMGEFDVPKPKSLLLIGPLNSGKRLLCEIIASELDAVFMNL-SPENTYKYAK 660
            ||:|.    |....:|   |..|:.:||.||...||.||...||.|||...:.: :||.....:.
Mouse   278 KMLIHMRHPEVYQHLG---VVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSG 339

  Fly   661 DLKYFLHVILKVAKAFQPTIMYIEEAHRLFWKKVPPEAVEINPRLLGTSLASKI------LKPLK 719
            :.:..|..:...|.:..|.|::|:|...:..|:      |:..:.:...:.:::      |..:.
Mouse   340 ESEQKLRELFDQAVSNAPCIVFIDEIDAITPKR------EVASKDMERRIVAQLLTCMDDLNNVA 398

  Fly   720 KNDKIVLVGTSNMPWAANGGIKRA--FQKVLLIPKCDYGTSFLLWLELMTENAPDDMKEYAYSAL 782
            ...:::::|.:|.|.:.:..::||  |.:.:.:                  ..||:      :|.
Mouse   399 ATARVLVIGATNRPDSLDPALRRAGRFDREVCL------------------GIPDE------AAR 439

  Fly   783 ARVLQAYNSGDIDDNVKETLNIDRKMRL 810
            .|:||               .:.||:||
Mouse   440 ERILQ---------------TLCRKLRL 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14183	NP_649172.3	AAA	622..751	CDD:278434	30/137 (22%)
Nvl	NP_080447.1	Interaction with RPL5. /evidence=ECO:0000250|UniProtKB:O15381	1..219		39/195 (20%)
		Nucleolin_bd	2..72	CDD:293330	4/34 (12%)
		Nucleolar localization signal. /evidence=ECO:0000269|PubMed:21474449	49..52		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..234		32/164 (20%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381	85..88		0/2 (0%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381	217..231		1/13 (8%)
		Interaction with WDR74. /evidence=ECO:0000250|UniProtKB:O15381	266..473		51/240 (21%)
		SpoVK	283..842	CDD:223540	44/218 (20%)
		AAA	300..432	CDD:278434	30/155 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..523
		AAA	617..747	CDD:278434

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900