DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14183 and iqca1

DIOPT Version :9

Sequence 1:	NP_649172.3	Gene:	CG14183 / 40192	FlyBaseID:	FBgn0036931	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_009300551.1	Gene:	iqca1 / 553364	ZFINID:	ZDB-GENE-050208-768	Length:	845	Species:	Danio rerio

Alignment Length:	914	Identity:	248/914 - (27%)
Similarity:	422/914 - (46%)	Gaps:	153/914 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LIKKQNRLKKIEPPEEKAVSYKIYAELYVLYVELVNKLSFIYHNTFQVQKRALVRVLVENATQQL 84
            |::.:....::.|.:::...::..|..::.|:::...|..:|......|||.:|..:::....:|
Zfish    20 LLEDEYPTLELRPQKDRLQVFQTLATFFLRYMKIFRALEEVYDQIVHPQKRRVVHQVLDGVMGRL 84

  Fly    85 MQLKEELKDLEMSEYIYIDKALIARKLTPRDLVVWRSPQFLYRRPL----DIQNIIADNRLYMND 145
            ::||.|:.:||.||:.|.|..|...|:||.||.| ..|::..|..:    :.:.::|  .:...:
Zfish    85 VELKNEMVELEHSEFHYFDDLLQDFKMTPEDLEV-PIPRYFVREKMRALKEREKMLA--HVLAKE 146

  Fly   146 EEKEEKAAQDWV---PISEAVKLIQAHERARRARVYKSNIKYDKKKFLKVHQRKKINYKFTFKPD 207
            ...|.|:....|   .:..||.|:|..||||:.|             |:.|..|.|
Zfish   147 GRPEHKSVNRPVLSMSMERAVWLLQVSERARQGR-------------LRAHFMKTI--------- 189

  Fly   208 QAMSIPVKRTIFSADFLKADESCENLIKKDDVADTAIDDEEALSAIQNNAACKIQSCWRGYKTRK 272
                             :.:|...:|      ..:.:|.::|       |.| ||..||||:.|:
Zfish   190 -----------------RLEEQRRHL------GSSMLDPDQA-------ATC-IQKVWRGYRDRR 223

  Fly   273 IVKIRKRFKEELYGMKKI---RKLKRPNQTANSIMEMYKNEMLKKKLDEDFINLIN-DERTRLLQ 333
              ::.|...||:..:..|   ::...|.|.....:|..::.:.::...|....|:| .|..|.:.
Zfish   224 --RVNKECLEEMIFLGMIPAQQQTPSPAQLRAQQVERRRHIIQEEHEAEYQTALVNIKESVRAVD 286

  Fly   334 FRSPWMMEDISDHIRAWFKEFYDATGNFHPYPDPVKQGTVLVVIDET--MTPMEFQESLGKKPLS 396
            ...  :.|.:.:.||.||.|..||:|.|..:|.|...|:..:...:|  ....||
Zfish   287 GAD--IKESLQEQIRQWFLECRDASGKFPDFPSPEDGGSASIFAQKTPEQVAAEF---------- 339

  Fly   397 KAELKKLRDKEKKEKRKKKEKLKQLKMKEAKRRKKLR-----------DAGVIDIGYELTASKAI 450
                     ..|:|:|:||:|||..|.|:|..||:.:           |....:.|:::|.|..:
Zfish   340 ---------AAKEEEREKKKKLKSEKDKKANDRKEKKKGKPKGKGGKGDTEEEETGWKMTHSNFL 395

  Fly   451 ENIEETMKKYSKDWRNVDEYLNKNHDPIKEWVTEEQLAKIHQEVRGLVDEYMRVEYELLREALAK 515
            ..:.:..|.|.:.|:|.||..|.......:.|.||:..::..|:|..|||.||.|.:.|:..:.:
Zfish   396 PTVFKGAKLYKEVWQNRDEQQNFLQRFDAQLVREEKRLEVEVELRVQVDELMRQELKNLKLVVDR 460

  Fly   516 DNDEKYKALKVKYPKKKK------EKRKKKPKDMTGDRTLESLYNELKDAGIIEEIGHRDFDEFI 574
            |..:|.|.:|....||||      :|:|||.||:|.|||:||||.||...|||....:....::|
Zfish   461 DKGKKKKKVKKSSKKKKKKGRKTGKKKKKKEKDLTADRTIESLYEELVLEGIIIRPMNVKLSDYI 525

  Fly   575 TDFNFVADDTRDEDGLTTLGPAKGDIKMVIQ-ESMLGMGEFDV----PKPKSLLLIGPLNSGKRL 634
            .:::::....|..| :..: |:..|::.:|. ..:|.:|...|    |..::|||.||...||::
Zfish   526 GEYSYLGTTLRQAD-IEPM-PSLSDVRQLIALYGILPLGSQCVHERGPLIRALLLTGPQGVGKKM 588

  Fly   635 LCEIIASELDAVFMNLSPE---NTYKYAKDLKYFLHVILKVAKAFQPTIMYIEEAHRLFWKKVPP 696
            |...:.:|..|...||||.   ..|.....|:..||::.|||:..||::::|.:|.:.|:||||.
Zfish   589 LVHALCTETGANLFNLSPSTLAGKYPGKSGLQLLLHMVFKVARQLQPSVIWIGDAEKTFYKKVPK 653

  Fly   697 EAVEINPRLLGTSLASKILKPLKKNDKIVLVGTSNMPWAANGGIK---RAFQKVLLIPKCDYGTS 758
            ...|:.|:.|..:| .||||.:|..|::::||||..|:.|:  ||   :.::|::|||:.||.:.
Zfish   654 LEKEMEPKRLKKTL-PKILKSIKAEDRVLVVGTSRRPFDAD--IKPFCKVYKKIILIPRPDYASR 715

  Fly   759 FLLWLELMTENAPDDMKEYAYSALARVLQAYNSGDIDDNVKETLNIDRKMRLKNEALDPNEFLEY 823
            |.||.||:..:......:...|:||:|...|..|.|...: :|:.|..::.|  :|..|...:|:
Zfish   716 FTLWKELLQAHGALLDPKLDLSSLAKVTDGYTQGHILQAI-QTILIPHRLEL--QAKRPLTAVEF 777

  Fly   824 F--LSKNEPPIFPPDEKIMDKFNKWFGSSNKLEKLR------------------KSYMAQKLAKA 868
            .  |::.: |::..:|   :.|..|: |...|.|.|                  |....||..|.
Zfish   778 IPPLARQD-PVYKEEE---ESFKAWY-SRTPLGKKRARAAKASEEQAILKKGKTKGGKLQKKGKE 837

  Fly   869 SKKK 872
            .|||
Zfish   838 GKKK 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14183	NP_649172.3	AAA	622..751	CDD:278434	50/134 (37%)
iqca1	XP_009300551.1	SpoVK	<576..748	CDD:223540	64/174 (37%)
iqca1	XP_009300551.1	AAA	576..691	CDD:278434	45/115 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578652
Domainoid	1	1.000	79	1.000	Domainoid score	I8614
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D127946at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103079
Panther	1	1.100	-	-	O	PTHR14690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750