DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14183 and PEX1

DIOPT Version :9

Sequence 1:	NP_649172.3	Gene:	CG14183 / 40192	FlyBaseID:	FBgn0036931	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_000457.1	Gene:	PEX1 / 5189	HGNCID:	8850	Length:	1283	Species:	Homo sapiens

Alignment Length:	1081	Identity:	184/1081 - (17%)
Similarity:	370/1081 - (34%)	Gaps:	305/1081 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EIGKLIKKQNRLKKIEPPEEKAVSYKIYAELYV-LYVELVNKLSFIYHNTFQVQKRALVRVLVEN 79
            |:..:..:|:.|.:|.....||: :.::.:... :::::|..:....:...:...:.|::.....
Human   120 ELHAVSLEQHLLDQIRIVFPKAI-FPVWVDQQTYIFIQIVALIPAASYGRLETDTKLLIQPKTRR 183

  Fly    80 ATQQLMQLKEELKDLEMSEYIYIDKALI----ARKLTPRDLVVWRSPQFLYRRPLDIQNIIA--- 137
            |.:.... |.:.:..::..|....|.::    .::|....:.:..|.:.....|:|..::.:
Human   184 AKENTFS-KADAEYKKLHSYGRDQKGMMKELQTKQLQSNTVGITESNENESEIPVDSSSVASLWT 247

  Fly   138 -DNRLYMNDEEKEEKAAQDW---------------VPISEAVKLIQAHERARRARVYKSNIKYDK 186
             ...::....||:::.:  |               ||:....::.    :::...:|.::.....
Human   248 MIGSIFSFQSEKKQETS--WGLTEINAFKNMQSKVVPLDNIFRVC----KSQPPSIYNASATSVF 306

  Fly   187 KKFLKVH------QRKKINYKFT---------FKPDQAMSIPVKRTIFSADFLKADESCENLIKK 236
            .|...:|      :...:...||         ..|.|..| ..|:.:.|.:  |..:..|.|.:|
Human   307 HKHCAIHVFPWDQEYFDVEPSFTVTYGKLVKLLSPKQQQS-KTKQNVLSPE--KEKQMSEPLDQK 368

  Fly   237 DDVADTAIDDEEALSAIQNNAACKIQSCWRG-------YKTRKIVKI------------RKRFKE 282
            ...:|...:||:         ||.:|..|.|       .|..|.|::            |||...
Human   369 KIRSDHNEEDEK---------ACVLQVVWNGLEELNNAIKYTKNVEVLHLGKVWIPDDLRKRLNI 424

  Fly   283 ELYGMKKIRKLKRPNQTANSIMEMYKNEMLKKKLDED-----FINLINDERTRLLQF---RSPWM 339
            |::.:.:|..::...:...| :::...|.|.|.:.|:     |.:.:....|.:|..   ...::
Human   425 EMHAVVRITPVEVTPKIPRS-LKLQPRENLPKDISEEDIKTVFYSWLQQSTTTMLPLVISEEEFI 488

  Fly   340 MEDISDHIR--------AWFKEFYDATGNFHPYPDPVKQGTVLVVIDETMTPMEFQE-------- 388
            ..:..|.::        :|.||  .....|...|:.:::.|:.|::|    ||..:|
Human   489 KLETKDGLKEFSLSIVHSWEKE--KDKNIFLLSPNLLQKTTIQVLLD----PMVKEENSEEIDFI 547

  Fly   389 -------------SLG------------KKPLSKAELKKLRDKEKKE------KRKKKEKLKQLK 422
                         |||            .:|||:..:..:.......      |...|..|.:..
Human   548 LPFLKLSSLGGVNSLGVSSLEHITHSLLGRPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAI 612

  Fly   423 MKEAKRRKKLRDAGVIDIGYELTASKAIENIEETMK----------------------------- 458
            .|||  ..|| ||.|..:..:....|.:|||::|::
Human   613 CKEA--FDKL-DAHVERVDCKALRGKRLENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVP 674

  Fly   459 --KYSKDWRNVDEYLNKNHDPIKEWVTEEQLAKI------HQEVRGLVDEYMRVEYELLREALAK 515
              ::|.|........:..:|.|||:::...|..:      .|.:..|:.....|......:.:..
Human   675 EHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQP 739

  Fly   516 DNDEKYKALKVKYPKKKKEKRKKKPKDMTGDRTLESLYNELKDAGIIEEIGHRDFDEFIT-DFNF 579
            .|.|:...:.....|.|.:....|..|:       .|.:..|:.|           .|:. ||..
Human   740 PNQEQRCEILCNVIKNKLDCDINKFTDL-------DLQHVAKETG-----------GFVARDFTV 786

  Fly   580 VAD------------DTRDEDGLTTLGPAKG-----------------------------DIKMV 603
            :.|            .||::..||||...|.                             :::.:
Human   787 LVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQI 851

  Fly   604 IQESMLGMGEF-------DVPKPKSLLLIGPLNSGKRLLCEIIASELDAVFMNL-SPENTYKYAK 660
            :.:::....::       .:.:...:||.||..:||.||..:||.|....|::: .||...||..
Human   852 LMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIG 916

  Fly   661 DLKYFLHVILKVAKAFQPTIMYIEEAHRLFWKKVPPEAVEINPRLLGTSLASKILKP-LKKNDKI 724
            ..:..:..|...|:|.:|.|::.:|     ::.:.|.....|     |.:..:::.. |.:.|.:
Human   917 ASEQAVRDIFIRAQAAKPCILFFDE-----FESIAPRRGHDN-----TGVTDRVVNQLLTQLDGV 971

  Fly   725 -------VLVGTSNMPWAANGGIKRAFQKVLLIPKCDY-----GTSFLLWLELMTENAP------ 771
                   ||..||. |...:..:.|..:    :.||.|     ..|.|..|.:::::.|
Human   972 EGLQGVYVLAATSR-PDLIDPALLRPGR----LDKCVYCPPPDQVSRLEILNVLSDSLPLADDVD 1031

  Fly   772 -------------DDMKEYAYSALARVLQAY----------NSGDIDDNVKETLNIDRKMRLKNE 813
                         .|:|...|:|....|...          :|.|.|.::...:.::......:.
Human  1032 LQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLSLSSMVFLNHSSGSDDS 1096

  Fly   814 ALDPNEFLEYFLSKNEPPIFPPDEKIMDKFNKWFGSSNKLE 854
            |.|....|:..|...|.....|||...:.:..:||||.:.|
Human  1097 AGDGECGLDQSLVSLEMSEILPDESKFNMYRLYFGSSYESE 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14183	NP_649172.3	AAA	622..751	CDD:278434	33/137 (24%)
PEX1	NP_000457.1	PEX-2N	19..98	CDD:286362
		PEX-1N	104..179	CDD:286361	8/59 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..367		6/23 (26%)
		SpoVK	595..1063	CDD:223540	91/503 (18%)
		AAA	595..731	CDD:278434	26/138 (19%)
		AAA	877..1006	CDD:278434	36/143 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1260..1283
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900