DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14183 and Pex1

DIOPT Version :9

Sequence 1:	NP_649172.3	Gene:	CG14183 / 40192	FlyBaseID:	FBgn0036931	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_001102690.1	Gene:	Pex1 / 500006	RGDID:	1559939	Length:	1283	Species:	Rattus norvegicus

Alignment Length:	877	Identity:	158/877 - (18%)
Similarity:	284/877 - (32%)	Gaps:	282/877 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 KFLKVHQRKKINYKFTFKPDQAMSIPVKRTIFSAD----FLKADESCENLIKKDDVADTAIDDEE 248
            |.:|:|..|:..    .|..|.:.:|.|....|..    .:.:|.|       ::.|:|
  Rat   333 KLVKLHSPKQQQ----DKSKQGVLLPEKEKQLSQSPGHKRIGSDGS-------EEAAET------ 380

  Fly   249 ALSAIQNNAACKIQSCWRGYK--------TRKI-----------VKIRKRFKEELYGMKKIRKLK 294
                      |.::..|.|.:        |:.:           ..:|||...|::.:.:|
  Rat   381 ----------CVLKVVWNGLEELKNATEFTKSLEPLHHGKVWIPADLRKRLNIEMHAVVRI---- 431

  Fly   295 RPNQTANSI---MEMYKNEMLKKKLDEDFINLINDERTRLLQFRSPWMMED-------------- 342
            .|.:|...|   :.:...|.|.:.:.|:.:..:          .|.|:.|.
  Rat   432 TPLETTPVIPRALRLQPAENLPRDVSEEEVKAV----------FSSWLQESATTMFPLIISKQEC 486

  Fly   343 ISDHIRAWFKEFYDATGNFHPYPDPVKQG-TVLVV---------IDETMTPM--EFQE------- 388
            |...|:...|||  :....|......:|| ||.|:         :...:.||  |..|
  Rat   487 IKLEIKDGLKEF--SLSIVHSQEKEKEQGRTVFVLSPILLQKISVQVLLEPMIGEHSEEIDILLP 549

  Fly   389 -----SLG------------------KKPLSK---AELKKLRDKE---KKEKRKKKEKLKQLKMK 424
                 |||                  .:|||:   |.:..||:..   ...|...|..|.:...|
  Rat   550 SLTLSSLGGVSSLSVSAMEHITHSLLGRPLSRQLMALVAGLRNGALLITGGKGSGKSTLAKAICK 614

  Fly   425 EAKRRKKLRDAGVIDIGYELTASKAIENIEETMKKYSKD--WRNVDEYL--------------NK 473
            ||   ....||.|..:..:....|.:|:|::.::....:  ||.....|              ..
  Rat   615 EA---HDALDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPSTPEH 676

  Fly   474 NHDP---------------IKEWVTEEQLAKI-------HQEVRGLVDEYMRVEYELLREALAKD 516
            .|.|               |||:|:...|..:       |.....||.......::.::.....|
  Rat   677 EHSPEAVQSQRLAHALNNMIKEFVSMGSLVALIATSQLQHSLHPSLVSAQGVHTFQCIQHIQPPD 741

  Fly   517 NDEKYKALKVKYPKKKKEKRKKKPKDMTGDRTLESLYNELKDAGIIEEIGHRDFDEFI-----TD 576
            .:::.:.|......|......|.|     |..|:.:..|      .|....|||...:     :.
  Rat   742 QEQRCEILHSVVKNKLGCDISKSP-----DLDLKCIAKE------TEAFVARDFTVLVDRAIHSS 795

  Fly   577 FNFVADDTRDEDGLTTLGPAKG-----------------------------DIKMVIQESMLGMG 612
            .:...:.||:...|||....|.                             :::.::.:::....
  Rat   796 LSRQQNPTREGLTLTTADFQKALRGFLPASLRNVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPA 860

  Fly   613 EF-------DVPKPKSLLLIGPLNSGKRLLCEIIASELDAVFMNL-SPENTYKYAKDLKYFLHVI 669
            ::       .:.:...:||.||..:||.||..::|.|....|::: .||...||....:..:..:
  Rat   861 KYPELFANLPIRQRTGILLYGPPGTGKTLLAGVVARESGMNFISIQGPELLSKYIGASEQAVRDV 925

  Fly   670 LKVAKAFQPTIMYIEEAHRLFWKKVPPEAVEINPRLLGTSLASKILKP-LKKNDKI-------VL 726
            ...|:|.:|.|::.:|     ::.:.|.....|     |.:..:::.. |.:.|.:       ||
  Rat   926 FIRAQAAKPCILFFDE-----FESIAPRRGHDN-----TGVTDRVVNQLLTQLDGVEGLQGVYVL 980

  Fly   727 VGTSNMPWAANGGIKRAFQKVLLIPKCDY-----GTSFLLWLELMTENAP--------------- 771
            ..||. |...:..:.|..:    :.||.|     ..|.|..|.:::::.|
  Rat   981 AATSR-PDLIDPALLRPGR----LDKCVYCPPPDQVSRLEILTVLSKSLPLADDVDLQHVASVTE 1040

  Fly   772 ----DDMKEYAYSALARVLQAY----------NSGDIDDNVKETLNIDRKMRLKNEALDPNEFLE 822
                .|:|...|:|....||..          :|.|.|.::...:.::......:.|.|....|:
  Rat  1041 SFTGADLKALLYNAQLEALQGRLLPGGLHDGGSSSDSDLSLSSMVFLNHSSGSDDSAGDGECGLD 1105

  Fly   823 YFLSKNEPPIFPPDEKIMDKFNKWFGSSNKLE 854
            ..|...|.....|||...:.:..:||||.:.|
  Rat  1106 QSLVSLEMSEILPDESKFNMYRLYFGSSYESE 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14183	NP_649172.3	AAA	622..751	CDD:278434	31/137 (23%)
Pex1	NP_001102690.1	PEX-2N	19..98	CDD:286362
		PEX-1N	104..179	CDD:286361
		AAA	591..741	CDD:214640	26/152 (17%)
		AAA	595..724	CDD:278434	24/131 (18%)
		AAA	877..1009	CDD:214640	34/146 (23%)
		AAA	877..1006	CDD:278434	34/143 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900