Protein Alignment CG14183 and NVL

DIOPT Version :9

• Sequence 1: NP_649172.3
• Gene: CG14183 / 40192
• FlyBaseID: FBgn0036931
• Length: 872
• Species: Drosophila melanogaster
• Sequence 2: XP_016856867.1
• Gene: NVL / 4931
• HGNCID: 8070
• Length: 917
• Species: Homo sapiens
• Alignment Length: 951
• Identity: 172/951 - (18%)
• Similarity: 326/951 - (34%)
• Gaps: 276/951 - (29%)

  Fly    25 NRLKKIEPPEEKAVSYKI------YAELYVLYVELVNKLSFIYHNTFQVQKRALVRVLVENATQQ 83
            |:||      ::.:.|..      |.::.|    |.:.|..:|...:..:||...|:.||... .
Human    11 NKLK------QRVIQYLTSNKCGKYVDIGV----LASDLQRVYSIDYGRRKRNAFRIQVEKVF-S 64

  Fly    84 LMQLKEELKDLEMSEYIYIDK-------------------ALIARKLTPRDLVVWRSPQFLYRRP 129
            ::..::|||:|...|..::.|                   ||....||.  ::..::...|..:|
Human    65 IISSEKELKNLTELEDEHLAKRARQGEEDNDVSLCHPGFSALAQSWLTA--VLTSQAQAILPPQP 127

  Fly   130 LDIQNIIADNRLYMNDEEKEEKAAQDWVPISEAVKLIQAHERARRARVYKSNIKYDKKKFLKVHQ 194
            .......:|:...|.|....:.|               .|..:....:|:...........::.|
Human   128 HRYTESYSDDDSSMEDYPDPQSA---------------NHMNSSLLSLYRKGNPDSVSNTPEMEQ 177

  Fly   195 RK------KINYKFTFKPDQAMSIPVKRTIFSAD----------------FLKADESCENLIKKD 237
            |:      :|:.|       ..|||:|.....::                ||  |.|||....|.
Human   178 RETTSSTPRISSK-------TGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFL--DLSCEKSNPKK 233

  Fly   238 DVADTAIDDEEALSAIQNNAACKIQSCWRGYKTRKIVKIRKRFKEELYG------MKKIRKLKRP 296
            .:  |.|.|.:..|.::::...|      |....|..|.:|...:|:.|      .||.:.....
Human   234 PI--TEIQDSKDSSLLESDMKRK------GKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLE 290

  Fly   297 NQTAN-SIMEMYKNEMLKKKLDEDFINLINDE----------------------RTRL------- 331
            .|.:| ...::..|:|..|::.:..|::.:.|                      :|.|
Human   291 FQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGA 355

  Fly   332 --------------------------------LQFRSPWMMEDISDHIRAWFKEFYDATGNFHPY 364
                                            |:..:|.::..:|.......:|.::
Human   356 ECSGMITAHCSFDFSGSNDPPASASQELDLPILKVAAPEIVSGVSGESEQKLRELFE-------- 412

  Fly   365 PDPVKQGTVLVVIDE--TMTPMEFQESLGKKPLSKAELKKLRDKEKKEKRKKKEKLKQLKMKEAK 427
             ..|.....::.|||  .:||             |.|:.. :|.|::...:....:..|....|.
Human   413 -QAVSNAPCIIFIDEIDAITP-------------KREVAS-KDMERRIVAQLLTCMDDLNNVAAT 462

  Fly   428 RRKKLRDAGVIDIGYELTASKAIENIEETMKKYSKDWRNVDEYLNKNHDPIKEWVTEEQLAKIHQ 492
            .|       |:.||    |:...::::..:::..:..|.:  .|....:..:|.:.:....|:..
Human   463 AR-------VLVIG----ATNRPDSLDPALRRAGRFDREI--CLGIPDEASRERILQTLCRKLRL 514

  Fly   493 -------EVRGLVDEYMRVE-YELLREA--------LAKDNDEKYKALKVK-YPKK--KKEKRKK 538
                   .:..|...::..: ..|.|||        |.|..:::.|..::: .|.|  ::|:...
Human   515 PQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGT 579

  Fly   539 KPKDMTGDRTLESLYNELKDAGIIEE-------IGHRDF-------------DEFITDFNF---- 579
            :|...|.|. |:.|...|:|...:.|       |...||             :.|:|..|.
Human   580 EPTSETQDE-LQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWAD 643

  Fly   580 --VADDTRDEDGLTTLGPAKGDIKMVIQESMLGMGEFDVPKPKSLLLIGPLNSGKRLLCEIIASE 642
              ..:|.|:|..:..|.|    ::...|...||:     ..|..:||.||...||.||.:.:|:|
Human   644 IGALEDIREELTMAILAP----VRNPDQFKALGL-----VTPAGVLLAGPPGCGKTLLAKAVANE 699

  Fly   643 LDAVFMNL-SPENTYKYAKDLKYFLHVILKVAKAFQPTIMYIEEAHRLFWKKVPPE---AVEINP 703
            ....|::: .||....|..:.:..:..:.:.||...|.:::.:|...|..::...|   :|.:..
Human   700 SGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVN 764

  Fly   704 RLLGTSLASKILKPLKKNDKIVLVGTSNMPWAANGGIKR--AFQKVLLI---PKCDYGTSFLLWL 763
            :||..      :..|:...::.::..:|.|...:..|.|  ...|.|.:   |..|.    |..|
Human   765 QLLTE------MDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADR----LAIL 819

  Fly   764 ELMTENA--PDDMKEYAYSALARVLQ--AYNSGDIDDNVKE 800
            :.:|:|.  |....:....|:|..|:  .|...|:...|:|
Human   820 KTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVRE 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14183	NP_649172.3	AAA	622..751	CDD:278434	30/137 (22%)
NVL	XP_016856867.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810