DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14183 and IQCA1L

DIOPT Version :9

Sequence 1:	NP_649172.3	Gene:	CG14183 / 40192	FlyBaseID:	FBgn0036931	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_001291348.1	Gene:	IQCA1L / 392843	HGNCID:	22831	Length:	818	Species:	Homo sapiens

Alignment Length:	910	Identity:	250/910 - (27%)
Similarity:	427/910 - (46%)	Gaps:	131/910 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFDLNHKFWVYTRKEIGKLIKKQNRLKKIEPPEEK-AVSYKIYAELYVLYVELVNKLSFIYHNT 64
            ||.....:.|..:...:.:|:.::..|.:..|..|: :..|:: |.||:.|:.|:.:...:|...
Human     1 MSEGAYQRLWESSHATLQELLDQEQLLLEPAPDRERQSFQYRL-ASLYLHYLGLLRRFDTVYDQM 64

  Fly    65 FQVQKRALVRVLVENATQQLMQLKEELKDLEMSEYIYIDKALIARKLTPRDLVVWRSPQFLYRRP 129
            .|.|||.|:|.|::....::::||:||...::.|...:|:.|...||||.||.|.....||..:.
Human    65 VQPQKRRLLRRLLDGVAGRVLELKDELVRADLCENHCLDRVLQDFKLTPADLEVPIPKYFLLEQS 129

  Fly   130 LDIQN---IIAD--NRLYMNDEEKEEKAAQDWVPISEAVKLIQAHERARRARVYKSNIKYDKKKF 189
            ..::.   |:|:  :||    |....:.:...:..:||:.|:|..||||:.|:
Human   130 TTVRERGLILAEILSRL----EPVSSQKSFTGMHRTEAIILVQKAERARQGRL------------ 178

  Fly   190 LKVHQRKKINYKFTFKPDQAMSIPVKRTIFSADFLKADESCENLIKKDDVADTAIDDEEALSAIQ 254
                                          .|.|::.       |::|:..|..|.::......|
Human   179 ------------------------------RATFMRE-------IRRDEEQDGRIREDGWHKFSQ 206

  Fly   255 NNAACKIQSCWRGYKTRKIVKIRKRFKEELYGMKKIRKLKRPNQTAN-SIM-------EMYKNEM 311
            ..||..||..|:||..||..:..:|.:.|..||     |..|||..: ||:       ::.:...
Human   207 GQAAVTIQKVWKGYLQRKRTQQDRRMEMEFIGM-----LPSPNQVEHLSIISQPCLVEDVQRLRQ 266

  Fly   312 LKKKLDEDFINLINDERTRLLQFRSPWMMEDISDHIRAWFKEFYDATGNFHPYPDPVKQGTVLVV 376
            ::|  :|:|...:......|::...|.|.|.:.:.||.||.|.:|.||.|..|||....|:..:.
Human   267 MEK--EEEFRAAMVKAHDSLVETEGPDMKEKMKEQIRQWFIECHDLTGRFPDYPDASSGGSYSIF 329

  Fly   377 IDETMTPMEFQESLGKKPLSKAELKKLRDKEKKEKRKKKEKLKQLKMKEAKRRKKLRDAGVIDIG 441
            .|:|...:..:..:..:...|.|.:|.::|.|.||.|||.       ||.|.:|     |.:|..
Human   330 ADKTPEQVRMELEMQMQENRKKEQEKSKEKGKDEKEKKKG-------KEEKAKK-----GEVDAV 382

  Fly   442 YELTASKAIENIEETMKKYSKDWRNVDEYLNKNHDPIKEWVTEEQLAKIHQEVRGLVDEYMRVEY 506
            .::..||.|..|....::|...|:|..|.::.:.:...|.:.||:..::..|:|..|||.||.|.
Human   383 LQVLPSKCIPMICAGHEEYLNTWKNRCESIHPSQNYDSETLREEKRKEVELEIRIQVDELMRQEL 447

  Fly   507 ELLREALAKDNDEKYKALKVKYPKKKKEKR--KKKPKDMTGDRTLESLYNELKDAGIIEEIGHRD 569
            ..||.|:.|:.:...:|     |||...|:  |||.||:|.||::||||.||..:|::.:.....
Human   448 RKLRLAVDKEEERPLRA-----PKKTPGKKTGKKKEKDLTSDRSVESLYEELVISGLLRKSESVA 507

  Fly   570 FDEFITDFNFVADDTRDEDGLTTLG-------PAKGDIKM-VIQESMLGMGEFDV----PKPKSL 622
            ..::|.||.::.         :||.       |:..||:. |...::|.:|..|:    |..:|:
Human   508 LKDYIGDFLYLG---------STLSLVKKLPMPSLFDIRQNVALYAVLRLGSPDIHIMAPLIRSI 563

  Fly   623 LLIGPLNSGKRLLCEIIASELDAVFMNLSPEN---TYKYAKDLKYFLHVILKVAKAFQPTIMYIE 684
            ||:||...||::|.:.:.:|..|...:|||||   .|......:..:|::.|||:..||::::|.
Human   564 LLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQMMVHIVFKVARLLQPSVIWIG 628

  Fly   685 EAHRLFWKKVPPEAVEINPRLLGTSLASKILKPLKKNDKIVLVGTSNMPWAAN-GGIKRAFQKVL 748
            .|.:.|:||.|.|..|::|:.:...| :|.|:.|...|:::|:||::.|..|. .|:.|.::::|
Human   629 NAEKNFYKKTPKEDKEMDPKRIKKDL-TKALRLLTPGDRVMLIGTTSRPQLAEMRGLCRVYERIL 692

  Fly   749 LIPKCDYGTSFLLWLELMTENAPDDMKEYAYSALARVLQAYNSGDIDDNVKETLNIDRKMRLKNE 813
            .:|:.||.:.::||..::........:....||||:|...|..|.|...::..|:..|.::|...
Human   693 FMPRPDYASRYVLWKRMIEARGIQPTQHLDISALAKVSDGYTPGHILQAIQSVLSERRFLQLSKR 757

  Fly   814 ALDPNEFLEYFLSKNEPPIFPPDEKIMDKFNKWFGSSNKLEKLRKSYMAQ------KLAKASKKK 872
            .|..:|||.. |.|.:|.....:|.:.|    |:..:...:|..|..|.|      ||.|..||:
Human   758 PLVASEFLGQ-LVKLDPVYREEEESLKD----WYFKTPLGKKSMKHRMDQLEAEEAKLDKEKKKR 817

Fly 873 872
Human 818 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14183	NP_649172.3	AAA	622..751	CDD:278434	43/132 (33%)
IQCA1L	NP_001291348.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..377		14/44 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..482		10/28 (36%)
		SpoVK	<561..734	CDD:223540	54/173 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	795..818		8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145391
Domainoid	1	1.000	65	1.000	Domainoid score	I10087
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D127946at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103079
Panther	1	1.100	-	-	O	PTHR14690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750