DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14183 and Spast

DIOPT Version :9

Sequence 1:	NP_649172.3	Gene:	CG14183 / 40192	FlyBaseID:	FBgn0036931	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_008762708.1	Gene:	Spast / 362700	RGDID:	1308494	Length:	614	Species:	Rattus norvegicus

Alignment Length:	348	Identity:	81/348 - (23%)
Similarity:	144/348 - (41%)	Gaps:	77/348 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   538 KKPKDMTGDRTLES-----LYNELKDAGII--------EEIGHRDFDEFITDFNFVADDTRDEDG 589
            :|.||:...|.::|     :.||:.|.|..        :|:..:...|.:     :....|.|..
  Rat   307 RKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQELAKQALQEIV-----ILPSLRPELF 366

  Fly   590 LTTLGPAKGDIKMVIQESMLGMGEFDVPKPKSLLLIGPLNSGKRLLCEIIASELDAVFMNLSPEN 654
            .....||:|                       |||.||..:||.:|.:.:|:|.:|.|.|:|..:
  Rat   367 TGLRAPARG-----------------------LLLFGPPGNGKTMLAKAVAAESNATFFNISAAS 408

  Fly   655 -TYKYAKDLKYFLHVILKVAKAFQPTIMYIEEAHRLFWKKVPPEAVEINPRLLGTSLASKILK-- 716
             |.||..:.:..:..:..||:..||:|::|:|...|..:           |..|...||:.||
  Rat   409 LTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCE-----------RREGEHDASRRLKTE 462

  Fly   717 --------PLKKNDKIVLVGTSNMPWAANGGIKRAFQKVLLIPKCDYGTSFLLWLELM-TENAPD 772
                    ....:|:::::|.:|.|...:..:.|.|.|.:.:...:..|..||...|: .:.:|.
  Rat   463 FLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPL 527

  Fly   773 DMKEYAYSALARVLQAYNSGDIDDNVKE-TLNIDRKMR---LKNEALDP------NEFLEYFLSK 827
            ..||.|  .|||:...|:..|:....|: .|...|:::   :||.:...      ::|.| .|.|
  Rat   528 TQKELA--QLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTE-SLKK 589

  Fly   828 NEPPIFPPDEKIMDKFNKWFGSS 850
            .:..:.|...:...::||.||.:
  Rat   590 IKRSVSPQTLEAYIRWNKDFGDT 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14183	NP_649172.3	AAA	622..751	CDD:278434	38/139 (27%)
Spast	XP_008762708.1	MIT_spastin	114..193	CDD:239142
		P-loop_NTPase	339..>395	CDD:304359	15/83 (18%)
		AAA	372..508	CDD:214640	41/169 (24%)
		AAA	376..506	CDD:278434	38/140 (27%)
		Vps4_C	<578..610	CDD:286426	7/32 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810