DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14183 and Nsf

DIOPT Version :9

Sequence 1:	NP_649172.3	Gene:	CG14183 / 40192	FlyBaseID:	FBgn0036931	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_032766.2	Gene:	Nsf / 18195	MGIID:	104560	Length:	744	Species:	Mus musculus

Alignment Length:	773	Identity:	159/773 - (20%)
Similarity:	276/773 - (35%)	Gaps:	214/773 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 RKKINYKFTF----KPDQ-----AMSIPVKR------------TIFSADFLKADESCENL----- 233
            |...|:|:.|    .|..     |.|:|.::            .::|.|  ||.:....:
Mouse    38 RTSPNHKYIFTLRTHPSVVPGCIAFSLPQRKWAGLSIGQDIEVALYSFD--KAKQCIGTMTIEID 100

  Fly   234 -IKKDDVADTAID-DEEALSAIQ--NNAACKIQSCWRGYKTRKIVKIRKRFKEELYGM--KKIRK 292
             ::|.::.....| |:.|...||  ||.|..:..           ::...|.::|:|:  |.|..
Mouse   101 FLQKKNIDSNPYDTDKMAAEFIQQFNNQAFSVGQ-----------QLVFSFNDKLFGLLVKDIEA 154

  Fly   293 L------------KRPNQTANSIMEMYKNEMLKKKLDEDFINLINDERT---RLLQFRSPWMMED 342
            :            ||  |.....:.:..:::..:|.:...:|||...:|   |.......|..|.
Mouse   155 MDPSILKGEPASGKR--QKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEK 217

  Fly   343 ISDHIRAWFKEFYD------ATGNFHP----------------YPDPVKQGTVLV-VIDETMTPM 384
            :.  |....|||.|      |:..|.|                |..|....|:|. .|.:.:...
Mouse   218 MG--IGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAR 280

  Fly   385 EFQESLGKKPLSK------AELKKL-RDKEKKEKR-KKKEKLKQLKMKE----AKRRKKLR-DAG 436
            |.:...|.:.|:|      |.::|| .|.|::::| .....|..:...|    .|:|..:. ..|
Mouse   281 EPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTG 345

  Fly   437 VIDIGYELTASKAIENIEETMKKYSKDWRNVDEY-LNKNHDPIKEWVTEEQLAKIHQEVRGLVDE 500
            |.|.......|| |:.:|:.        .|:... :....|.|.|.:......::..|: ||.||
Mouse   346 VHDTVVNQLLSK-IDGVEQL--------NNILVIGMTNRPDLIDEALLRPGRLEVKMEI-GLPDE 400

  Fly   501 YMRVEYELLREA-------LAKDNDEKYKALKVK-------------------------YPKKKK 533
            ..|::...:..|       |:.|.|.|..|::.|                         ..|.:.
Mouse   401 KGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEV 465

  Fly   534 EKRKKKPKDMTGDRTLESLYNELKDA-GIIEEIGHRDFDEFITDFNFVADDTRDEDGLTTLGPAK 597
            :..|.:...:|....|.||.|::|.| |..:|    |:..:|.            :|:...|
Mouse   466 DMEKAESLQVTRGDFLASLENDIKPAFGTNQE----DYASYIM------------NGIIKWG--- 511

  Fly   598 GDIKMVIQESMLGMGEFDVPKPK--------SLLLIGPLNSGKRLLCEIIASELDAVFMNL-SPE 653
            ..:..|:.:     ||..|.:.|        |:||.||.:|||..|...||.|.:..|:.: ||:
Mouse   512 DPVTRVLDD-----GELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD 571

  Fly   654 NTYKYAKDLK-YFLHVILKVAKAFQPTIMYIEEAHRLFWKKVPPEAVEINPRLLGTSLASKILKP 717
            ....:::..| ..:..|...|...|.:.:.:::..||.      :.|.|.||.....|.: :|..
Mouse   572 KMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLL------DYVPIGPRFSNLVLQA-LLVL 629

  Fly   718 LKK----NDKIVLVG-TSNMPWAANGGIKRAFQKVLLIPKCDYGTSFLLWLELM--------TEN 769
            |||    ..|::::| ||.........:..||...:.:|....|...|..|||:        |..
Mouse   630 LKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTI 694

  Fly   770 APDDMKEYAYSALARVLQAYNSGDIDDNVKETLNIDRKMR-------LKNEALDPNEF 820
            |.....:..:..:.::|..         ::.:|.:|.:.|       ::.|...|.:|
Mouse   695 AQQVKGKKVWIGIKKLLML---------IEMSLQMDPEYRVRKFLALMREEGASPLDF 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14183	NP_649172.3	AAA	622..751	CDD:278434	35/135 (26%)
Nsf	NP_032766.2	CDC48_N	6..83	CDD:215012	8/44 (18%)
		CDC48_2	111..183	CDD:215011	16/84 (19%)
		AAA	254..399	CDD:214640	33/154 (21%)
		AAA	256..397	CDD:278434	31/150 (21%)
		AAA	538..670	CDD:214640	37/138 (27%)
		AAA	539..668	CDD:278434	35/135 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900