DRSC/TRiP Functional Genomics Resources

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Protein Alignment kug and CELSR1

DIOPT Version :10

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:NP_001365257.1 Gene:CELSR1 / 9620 HGNCID:1850 Length:3019 Species:Homo sapiens


Alignment Length:2191 Identity:478/2191 - (21%)
Similarity:782/2191 - (35%) Gaps:761/2191 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  2346 YNLTIPENASFGTQILKINATDNDSGANAKLSYYIESINGQNNSELFYIDVTDGNLYLKTPLDYE 2410
            |.:.:.||...||.||:::|.....|...::|||:|.:..:.:...|.||...|.:...:.||.|
Human   250 YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRE 314

  Fly  2411 QIKYHHIVVNVKDHGSPSLSSRSNVFITVKDLNDNAPCFVEPSYFTKVSVAAVRGQFVALPKAYD 2475
            ..:.|.:.|...|:.:|..|:.:.:.:.|||.||                               
Human   315 TKETHVLRVKAVDYSTPPRSATTYITVLVKDTND------------------------------- 348

  Fly  2476 KDISDTDSLEYKIVYGNELQTYSIDKLTGVISLQNMLNFTDKSSTVLNISVSDGVHTAYARLKIS 2540
                                                                             
Human   349 ----------------------------------------------------------------- 348

  Fly  2541 LLPENVYSPLFDQSTYEAQVPENLLHGHNIITVKASDGDFGTYANLYYEIVSEEMKKIFLIDQTT 2605
                  :||:|:||.|..:|.|||..|:.::|::|||.|....|||.|.::.... .:|.:::::
Human   349 ------HSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAW-DVFQLNESS 406

  Fly  2606 GVITSKVTFDREKKDEYVVLLKVSDGGGKFG----FASLKVIVVDVNDNVPYFLLKEYKMVVSTT 2666
            ||::::...|||:..||.:|::.:|.|...|    .|::.:.|.|.|||.|.|..:.|.:.|...
Human   407 GVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPED 471

  Fly  2667 VEANQTILTVKAKDDDIVDNGSVHFQIVQKSNDKAVKDVIEINEKTGDIVFKSKAESYGVNSYQF 2731
            |..|..:|.|:|.|.|...|.::|:.|:.                                    
Human   472 VGLNTAVLRVQATDRDQGQNAAIHYSILS------------------------------------ 500

  Fly  2732 FVRASDRGEPQFHSEVPVSIEIIETDANIPTFEKSSVLLKIIESTPPGTVLTKLHMIGNYTFKFS 2796
                                                                     ||...:| 
Human   501 ---------------------------------------------------------GNVAGQF- 507

  Fly  2797 IAADQDHFMISDSGELILQQTLDREQQESHNLIVVAETSTVPVFFAYADVL-IDVRDENDNYPKF 2860
                   ::.|.||.|.:...||.|..:.::|.:.|:....|.....:.|: :.|.|.|||.|.|
Human   508 -------YLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIF 565

  Fly  2861 DNTFYSASVAENSEKVISLVKVSATDADTGPNGDIRY--------YLESDTENIQN-------IF 2910
            .::.:.|:|.||......:|.:.|.|||:|.|..:.|        :|...:...:|       .|
Human   566 VSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPF 630

  Fly  2911 DIDIYSGWITLLTSLDREVQSEYNFKVIAADNGHPKHDAKVPVTIKIVDYNDNAPVFKLPIEGLS 2975
            .|...|||||:...||||....|:|.|.|.|:|.|...:...|:|.::|.|||.|||        
Human   631 QIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVF-------- 687

  Fly  2976 VFENALPGTVLINLLLIDPDIEKQEMDFFIVSGDKQAQFQIGKSGELFIAKPLDREQLMFYNLSI 3040
                                                                             
Human   688 ----------------------------------------------------------------- 687

  Fly  3041 IATDGKFTAKANVEIDVKDINDNTPYCLKPRYHISTNESISIGTTLVEVKAIDFDFQSKLRFYLS 3105
                                       .:|.|.:..||..::|::::.::|.|.|..|.:.:.|:
Human   688 ---------------------------TQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLT 725

  Fly  3106 GKGA-DDFSIGKE--SGILKVASALDRETTPKYKLVAHVQDGKDFTQECFSEIIITVNDINDNMP 3167
            |... :.|::..:  .|::.:|..||.:...:|.|.....||   |:...:.::|.|.|.|.:.|
Human   726 GGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRP 787

  Fly  3168 IFSMAQYRVSVPEDAQLNTLITKVHAMDKDFGVNRQIKYSLMGENHDYFKISKSTGIIRLHKSLD 3232
            :|..:.|.|||.||..:.|.|..:.|.|:|.|.|.:|.|.                         
Human   788 VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYV------------------------- 827

  Fly  3233 RETISLFNLTVKAEDCGVPKLHSIATVAVNILDINDNPPEFSMRQYSCKILENATHGTEVCKVYA 3297
                                             |.|..|:                         
Human   828 ---------------------------------IQDPVPQ------------------------- 834

  Fly  3298 TSIDIGVNADIHYFIMSGNEQGKFKMDSTTGDLVLNATLDYEMSKFYFLTIQAIDGGTPPLSNNA 3362
                                   |::|..:|.:.....||||....|.|||.|.|.|.|..|:..
Human   835 -----------------------FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTT 876

  Fly  3363 YVNISILDINDNSPTFLQNLYRINVNEDIFVGSKILDVKATDEDSDVNGLVTYNIERGDN-IGQF 3426
            .:.|.|||.|||:|.||.:.|:.::.||....:.||.|.|||.||..||.:.|..:.||: .|.|
Human   877 TLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDF 941

  Fly  3427 SIDPKNGTISVSRPLDRETISHYTLEIQACDQGDPQRCN-SVPININILDTNDNAPIFSSSNYSV 3490
            .|:|.:|.|...|.||||.::.|.|...|.|:|.|...: ||.|.:.|||.|||||:|......:
Human   942 YIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELEL 1006

  Fly  3491 VLQENRLLGYVFLTFKISDADETPNTTPYTFDIRSGNEGGLFRLE-QDGSLRTASRFNHNLQDEF 3554
            .::||..:|.|....:.:|.||.|| ....:.|..|:....|:|: .:|.||.....:..::.|:
Human  1007 FVEENNPVGSVVAKIRANDPDEGPN-AQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREY 1070

  Fly  3555 VIQVRVFDNGTPPLYSDAWVVVKIIEESQYPPIVTPLEVTINSFEDDFSGAF----IGKVHASDQ 3615
            |:.|:.   .:.||.|.|.|.:.:::::..||::...::..|::..:.|.:|    ||.:.|.|.
Human  1071 VLVVQA---TSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDP 1132

  Fly  3616 DKYDELNFSLVSGPDDMYQSSKLFNISNNTGKIYAISNLDIGL---YKLNVSVSDGKFHVFSIVK 3677
            |..|.||::.|.|     ...:|..:...||::....:||...   ..:.||||||...|.:...
Human  1133 DVSDSLNYTFVQG-----NELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCT 1192

  Fly  3678 INVELVTNDMLKESVVIRFRRISASEFLLSHRKTFMRSIRNIMRCRQKDVILITLQSDYQKASQH 3742
            :.|.::|:|||..|:.:|...:|..:||......|:..:..::...:.||.:..:|:|...:|  
Human  1193 LRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSS-- 1255

  Fly  3743 AVGNRRARSIDSDLNVVFAVRKQQIIPDS--DEFFTSDEIRQTLIDKKNEIENETNLVVEDVLPS 3805
                       :.|||.|:.    ::|..  .:||.|:::::.:...:..:   |.:..:.||| 
Human  1256 -----------NILNVTFSA----LLPGGVRGQFFPSEDLQEQIYLNRTLL---TTISTQRVLP- 1301

  Fly  3806 TCQSNKNDCVHGECKQILQ---ILKNNVTTTFTDVISFAAPSYIPVN--TCVCRPGFDGKHCKET 3865
               .:.|.|:...|:..::   :|:.:.:..|....:.......|:|  .|.|.|||.|.:|:..
Human  1302 ---FDDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETE 1363

  Fly  3866 VNACSTDPCSPQRICMPSGSALGYQCVCPKGFSGTYCE--RKSSKCSNESCDMG----------- 3917
            ::.|.:|||.....|.....  ||.|.|.:.|:|.:||  .:|.:|:|..|..|           
Human  1364 IDLCYSDPCGANGRCRSREG--GYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGF 1426

  Fly  3918 --------------LFTAVSFGGKSYAHYKINKVKAKFTLENGFSYSLQIRTVQQTGTLLY---A 3965
                          ..|..||..:|:..::..:.:..||:      ||...|.::.|.|||   .
Human  1427 HCVCPPGEYERPYCEVTTRSFPPQSFVTFRGLRQRFHFTI------SLTFATQERNGLLLYNGRF 1485

  Fly  3966 SGKVDYNILEIINGAVQYRFDLGSGEGVISVS---SINISDGEWHQISLERSLNSAKVMVDNK-H 4026
            :.|.|:..|||::..||..|  .:||...:|:   ...:|||.||         |.:|...|| :
Human  1486 NEKHDFIALEIVDEQVQLTF--SAGETTTTVAPKVPSGVSDGRWH---------SVQVQYYNKPN 1539

  Fly  4027 VSHGSAP-GVNG----ILNIQSND----IFVGAEVRPH-------------------PSIIG--- 4060
            :.|...| |.:|    ::.:...|    :..|.::..:                   |.::|   
Human  1540 IGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVP 1604

  Fly  4061 --YEDI---QRGFIGCMANIKIAKESLPL--YISGGST---IAALKRFTNVEFKCDPSNVLVRLG 4115
              .||.   .|.|:|||.|:.:..:::.:  :|:...|   .||.:.|                 
Human  1605 NLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNF----------------- 1652

  Fly  4116 ICGSQPCANSGICKELDTDVFECACQPRYSGKHCE------------------------------ 4150
             |..:.|.|.|.|.. ..:::.|.|..|:.||:||                              
Human  1653 -CDGRRCQNGGTCVN-RWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYL 1715

  Fly  4151 -----------IDLDPCSSGPCLFGGRC--DY------HGPNNYSCTCPIHLSGKR--------- 4187
                       :.::..|.||..|..:.  :|      |||::..   .:.|||.|         
Human  1716 GLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVE---SVMLSGLRVTDGEWHHL 1777

  Fly  4188 ----------------------------------------------------------------- 4187
                                                                             
Human  1778 LIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTVRSVVVGGASEDKVSVRRGFRGCMQ 1842

  Fly  4188 ---------------------------CEYGKFCTPNPCKNGGICEEGDGISHCMC-RGYTGPTC 4224
                                       |:....||.:||.....|.:......|:| :||.|..|
Human  1843 GVRMGGTPTNVATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINC 1907

  Fly  4225 EIDVDECENQPCGNGATCINEPGS---FRCIC-PSYLTGASCGDPL 4266
               ||.|...||.|...|:..|||   :.|.| ||:. |..|.:.|
Human  1908 ---VDACHLNPCENMGACVRSPGSPQGYVCECGPSHY-GPYCENKL 1949

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637
Cadherin_repeat 883..976 CDD:206637
Cadherin_repeat 984..1082 CDD:206637
Cadherin_repeat 1092..1189 CDD:206637
Cadherin_repeat 1197..1295 CDD:206637
Cadherin_repeat 1303..1386 CDD:206637
Cadherin_repeat 1413..1502 CDD:206637
Cadherin_repeat 1510..1608 CDD:206637
Cadherin_repeat 1621..1713 CDD:206637
Cadherin_repeat 1724..1811 CDD:206637
Cadherin_repeat 1819..1927 CDD:206637
Cadherin_repeat 1948..2030 CDD:206637
Cadherin_repeat 2037..2136 CDD:206637
Cadherin_repeat 2144..2235 CDD:206637
Cadherin_repeat 2246..2336 CDD:206637
Cadherin_repeat 2345..2445 CDD:206637 29/98 (30%)
Cadherin_repeat 2453..2545 CDD:206637 0/91 (0%)
Cadherin_repeat 2555..>2633 CDD:206637 25/77 (32%)
Cadherin_repeat 2658..2759 CDD:206637 12/100 (12%)
Cadherin_repeat 2774..2856 CDD:206637 17/82 (21%)
Cadherin_repeat 2865..2963 CDD:206637 36/112 (32%)
Cadherin_repeat 2974..3063 CDD:206637 0/88 (0%)
Cadherin_repeat 3072..3165 CDD:206637 24/95 (25%)
Cadherin_repeat 3173..3269 CDD:206637 16/95 (17%)
Cadherin_repeat 3277..3374 CDD:206637 21/96 (22%)
Cadherin_repeat 3383..3479 CDD:206637 40/97 (41%)
Cadherin_repeat 3488..3579 CDD:206637 24/91 (26%)
Cadherin_repeat 3590..3681 CDD:206637 25/97 (26%)
EGF_CA 3866..3903 CDD:238011 11/36 (31%)
Laminin_G_2 3953..4077 CDD:460494 41/166 (25%)
EGF_CA <4121..4150 CDD:238011 9/28 (32%)
EGF_CA 4152..4189 CDD:238011 12/145 (8%)
EGF_CA 4195..4225 CDD:238011 9/30 (30%)
EGF_CA 4227..4262 CDD:214542 15/38 (39%)
CELSR1NP_001365257.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 205..242
Cadherin_repeat 250..349 CDD:206637 30/200 (15%)
Cadherin_repeat 357..455 CDD:206637 31/98 (32%)
Cadherin_repeat 464..561 CDD:206637 29/197 (15%)
Cadherin_repeat 569..683 CDD:206637 36/113 (32%)
Cadherin_repeat 691..785 CDD:206637 24/96 (25%)
Cadherin_repeat 793..888 CDD:206637 39/200 (20%)
Cadherin_repeat 897..995 CDD:206637 40/97 (41%)
Cadherin_repeat 1003..1097 CDD:206637 24/97 (25%)
Cadherin_repeat 1117..1198 CDD:206637 24/85 (28%)
EGF_CA 1364..1399 CDD:238011 11/36 (31%)
EGF_CA 1407..1441 CDD:238011 4/33 (12%)
LamG 1444..1627 CDD:238058 48/199 (24%)
EGF_CA 1651..1685 CDD:238011 11/52 (21%)
Laminin_G_2 1719..1849 CDD:460494 12/132 (9%)
EGF_CA 1874..1908 CDD:238011 11/36 (31%)
TNFRSF 1881..2011 CDD:473981 25/73 (34%)
CRD2 1898..1934 CDD:276930 15/38 (39%)
EGF_Lam 2002..>2040 CDD:238012
HormR 2052..2113 CDD:214468
GAIN 2130..2381 CDD:465137
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2291..2328
GPS 2407..2460 CDD:197639
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 2411..2461
7tm_GPCRs 2465..2718 CDD:475119
TM helix 1 2468..2492 CDD:320657
TM helix 2 2501..2522 CDD:320657
TM helix 3 2532..2554 CDD:320657
TM helix 4 2573..2589 CDD:320657
TM helix 5 2608..2631 CDD:320657
TM helix 6 2654..2676 CDD:320657
TM helix 7 2680..2705 CDD:320657
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2777..2939
Blue background indicates that the domain is not in the aligned region.

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