DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kug and Cdhr1

DIOPT Version :9

Sequence 1:	NP_001027138.2	Gene:	kug / 40191	FlyBaseID:	FBgn0261574	Length:	4699	Species:	Drosophila melanogaster
Sequence 2:	NP_446024.1	Gene:	Cdhr1 / 93662	RGDID:	620420	Length:	859	Species:	Rattus norvegicus

Alignment Length:	729	Identity:	204/729 - (27%)
Similarity:	317/729 - (43%)	Gaps:	92/729 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1406 VRKTSENVV--DLTENDKPGFLVTQILAVDDDNDQLWYNIS-NGNDDNTFYIGQDNGNILLSKYL 1467
            |..|:.|:.  .|.|:...|..|..:...|.:.|.:.|:|| :.:..:.|.:..:.|||.|.:.|
  Rat    32 VGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPNFGNITLVEEL 96

  Fly  1468 DYETQQSYNLTISVTDGTFTAFTNLLVQVIDINDNPPQFAKDVYHVNISENIEEESVIMQLHATD 1532
            |.|.:......||::||.......:::.|.|.||..|:|.::.|::.:.||....|.|.::.|.|
  Rat    97 DREREDEIEAIISISDGLNLVAEKVVIVVTDANDEAPRFLQEPYNILVPENTPAGSSIFKVQAED 161

  Fly  1533 RDEDK--KLFYHLHATQDPSSLALFRIDSISGNVIVTQ---RLDFEKTAQHILIVFVKDQGAPGK 1592
            :|...  .:.|.|.:...    :.|.:|..|| |:..|   .||:||:..|.:.|..||.|  |:
  Rat   162 KDTGSGGSVTYFLQSLHS----SKFTVDRHSG-VLRLQAGATLDYEKSRAHFITVVAKDGG--GR 219

  Fly  1593 RNYAKII--------VNVHDHNDHHPEFTAKIIQSKVPESAAIGSKLAEVRAIDRDSGHNAEIQY 1649
            ...|.::        :||.|..|..|.|........|.|....||::..|.|||.|.|....|.|
  Rat   220 LRGADVVFSATTTVTINVEDVQDTAPIFVGTPYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILY 284

  Fly  1650 SIITGNVGSVFEIDPTFGIITLAGNLNINKIQEYMLQVKAVDL---GNPPLSSQIPVHIIVTMSE 1711
            .::..:.| :|||:.|.|.|::..:....:.:.|.|.|:..::   |:|...|.:||.|.:....
  Rat   285 RLLNESDG-LFEINETSGAISVLQSPAQLRREVYELHVQVTEVNSSGSPAAQSTVPVIIRIVDLN 348

  Fly  1712 NDPPKF-----PTNNIAIEIFENLPIGTFV--TQVTARSS---SSIFFNIISGNINESFRINPST 1766
            |.||.|     |.|...:.:||:.|.|..:  .::|...|   ::..||:........||:.|.|
  Rat   349 NHPPTFYGESGPQNKFELSMFEHPPQGEILRGLKITVNDSDQGANAKFNLRLVGPGGIFRVVPQT 413

  Fly  1767 -------GVIVIN-GNIDYESIK--VFNLTVKGTNMAAE-SSCQNIIIHILDANDNIPYFVQNEY 1820
                   .:||.| ..||:|..|  .|.|.....|...: ||..:|:|.:||.|||:|.|..:.|
  Rat   414 VLNEAQVTIIVENSAAIDFEKSKSLTFKLLAIEVNTPEKFSSTADIVIQLLDTNDNVPKFTSHYY 478

  Fly  1821 VGALPESAAIGSYVLKVHDSSKDHLTLQVKDADVGVNGMVEYHIVDDLAKNFFKIDSTTGAI--E 1883
            :..:||:...||.|:.|          ...|.|.|..|.|:|.|. ....:.|.|..:||.|  :
  Rat   479 IARIPENVPGGSNVVAV----------TAVDPDTGPWGKVQYSIY-GTGSDLFLIHPSTGLIYTQ 532

  Fly  1884 LLRQLDYETNAGYTFDVTVSDM-GKPKLHSTTTAHVTIRVINVNDCPPVFNERELNVTLFLPTFE 1947
            ....||.|..:.|.|.|...|| |:..|     |.|.:.:::|||..|.|.:.....|:.|.|
  Rat   533 PWASLDAEGTSRYNFYVKAEDMDGRYSL-----AEVFVTLLDVNDHYPQFVQSVQEKTMVLGT-- 590

  Fly  1948 NVFVRQVSAKDAD----NDTLRFDIVDGNTNECFQIEKYTGII----TTRNFEILNN---ENDRD 2001
               ..::.|.|.|    |:.:.:.|........|.|:.:||.|    :.|:.|.|:|   ..:..
  Rat   591 ---PLKIEATDQDAEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSIRSLEALHNITPSGEYS 652

  Fly  2002 YALHVRASD---GIFSAILIVKIKVLSAIDSNFAFQRESYRFSAFENNTKVATIGLVNVIGNTLD 2063
            ::|.|:|.|   ..||...::||.    |.......|.|  .:||...||...:..|.|:...:.
  Rat   653 WSLQVQAKDRGSPSFSTTALLKID----ITDTERLSRSS--MAAFLIQTKDNPMKAVGVLAGVMA 711

  Fly  2064 ENVEYRILNPTQLF 2077
            ..|...:|..|..|
  Rat   712 IVVAITVLISTATF 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kug	NP_001027138.2	Cadherin_repeat	66..178	CDD:206637
		Cadherin_repeat	187..285	CDD:206637
		E_set	309..390	CDD:298831
		Cadherin_repeat	404..503	CDD:206637
		Cadherin_repeat	513..609	CDD:206637
		Cadherin_repeat	622..708	CDD:206637
		Cadherin_repeat	776..873	CDD:206637
		Cadherin_repeat	883..976	CDD:206637
		Cadherin_repeat	984..1082	CDD:206637
		Cadherin_repeat	1092..1189	CDD:206637
		Cadherin_repeat	1197..1295	CDD:206637
		Cadherin_repeat	1303..1386	CDD:206637
		Cadherin_repeat	1413..1502	CDD:206637	24/91 (26%)
		Cadherin_repeat	1510..1608	CDD:206637	30/110 (27%)
		Cadherin_repeat	1621..1713	CDD:206637	28/94 (30%)
		Cadherin_repeat	1724..1811	CDD:206637	29/102 (28%)
		Cadherin_repeat	1819..1927	CDD:206637	32/110 (29%)
		Cadherin_repeat	1948..2030	CDD:206637	23/95 (24%)
		Cadherin_repeat	2037..2136	CDD:206637	11/41 (27%)
		Cadherin_repeat	2144..2235	CDD:206637
		Cadherin_repeat	2246..2336	CDD:206637
		Cadherin_repeat	2345..2445	CDD:206637
		Cadherin_repeat	2453..2545	CDD:206637
		Cadherin_repeat	2555..>2633	CDD:206637
		Cadherin_repeat	2658..2759	CDD:206637
		Cadherin_repeat	2774..2856	CDD:206637
		Cadherin_repeat	2865..2963	CDD:206637
		Cadherin_repeat	2974..3063	CDD:206637
		Cadherin_repeat	3072..3165	CDD:206637
		Cadherin_repeat	3173..3269	CDD:206637
		Cadherin_repeat	3277..3374	CDD:206637
		Cadherin_repeat	3383..3479	CDD:206637
		Cadherin_repeat	3488..3579	CDD:206637
		Cadherin_repeat	3590..3681	CDD:206637
		EGF_CA	3866..3903	CDD:238011
		Laminin_G_2	3953..4077	CDD:280389
		EGF_CA	<4121..4150	CDD:238011
		EGF_CA	4152..4189	CDD:238011
		EGF_CA	4195..4225	CDD:238011
		EGF_CA	4227..4262	CDD:214542
Cdhr1	NP_446024.1	Cadherin_repeat	42..130	CDD:206637	23/87 (26%)
		Cadherin_repeat	139..242	CDD:206637	30/109 (28%)
		Cadherin_repeat	251..350	CDD:206637	28/99 (28%)
		Cadherin_repeat	364..469	CDD:206637	29/104 (28%)
		Cadherin_repeat	478..573	CDD:206637	33/110 (30%)
		Cadherin_repeat	580..679	CDD:206637	26/107 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..859
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000