DRSC/TRiP Functional Genomics Resources

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Protein Alignment kug and Celsr3

DIOPT Version :10

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:NP_112610.1 Gene:Celsr3 / 83466 RGDID:621787 Length:3313 Species:Rattus norvegicus


Alignment Length:1806 Identity:465/1806 - (25%)
Similarity:739/1806 - (40%) Gaps:380/1806 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  2734 RASDRGEPQF-----HSEVPVSIEIIETDANIPTFEKSSVLLKIIESTP-PGTVLTKLHMIGNYT 2792
            ||::| .|||     .:.||      |.:|      ..:.:|:::...| ||..       |...
  Rat   308 RAANR-HPQFPQYNYQTLVP------ENEA------AGTAVLRVVAQDPDPGEA-------GRLV 352

  Fly  2793 FKFSIAA-----DQDHFMIS-DSGELILQQTLDREQQESHNLIVVAETSTVPVFFAYADVLIDVR 2851
              :|:||     ..:.|.|. .||.:.....||||..|.|.|.|.|:....|...|...|.:.|.
  Rat   353 --YSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVA 415

  Fly  2852 DENDNYPKFDNTFYSASVAENSEKVISLVKVSATDADTGPNGDIRY-YLESDTEN--IQNIFDID 2913
            |.||:.|.|:...|..::.||.|:...::::.|||.|..||.::|| ::.|....  ....|:||
  Rat   416 DRNDHAPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGSPAARTAAAAAFEID 480

  Fly  2914 IYSGWITLLTSLDREVQSEYNFKVIAADNGH---PKHDAKVPVTIKIVDYNDNAPVFKLPIEGLS 2975
            ..||.|:....:|||....|...|.|:|.|.   |: .|.|.|.|.::|.|||||.|........
  Rat   481 PRSGLISTSGRVDREHMESYELVVEASDQGQEPGPR-SATVRVHITVLDENDNAPQFSEKRYVAQ 544

  Fly  2976 VFENALPGTVLINLLLIDPDIEKQEM-DFFIVSGDKQAQFQIGK-SGELFIAKPLDREQLMFYNL 3038
            |.|:..|.||::.:...|.|.:...: .:.|:||:.:..|.|.. :||:.:..|||.|....|.|
  Rat   545 VREDVRPHTVVLRVTATDKDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVMAPLDFEAEREYAL 609

  Fly  3039 SIIATDGKFTAKAN----VEIDVKDINDNTPYCLKPRYHISTNESISIGTTLVEVKAIDFDF--Q 3097
            .|.|.|......:|    ..|.|.||||::|..:...:.:|..|:..:|.:::.::|:|.|.  .
  Rat   610 RIRAQDAGRPPLSNNTGLASIQVVDINDHSPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGEN 674

  Fly  3098 SKLRFYLSGKGAD-DFSIGKESGILKVASALDRETTPKYKLVAHVQDGKDFTQECFSEIIITVND 3161
            |:|.:.|:|..:| .|.|...:|.:.|:..||||:...|......:|.........:.:.:||.|
  Rat   675 SRLEYSLTGVASDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLD 739

  Fly  3162 INDNMPIFSMAQYRVSVPEDAQLNTLITKVHAMDKDFGVNRQIKYSLMGEN-HDYFKISK--STG 3223
            :|||.|.|:|.:|.:.:.|||.:.|.:..|.|:|:|  .|..|.|.:.|.| .:.|.||.  ..|
  Rat   740 VNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGGMG 802

  Fly  3224 IIRLHKSLDRETISLFNLTVKAEDCGVPKLHSIATVAVNILDINDNPPEFSMRQYSCKILENATH 3288
            ::.|...||.:....|.|.:.|.|   ..||....|.:||.|.|.:.|.|....||..:.|:...
  Rat   803 LVTLALPLDYKQERYFKLVLTASD---RALHDHCYVHINITDANTHRPVFQSAHYSVSMNEDRPV 864

  Fly  3289 GTEVCKVYATSIDIGVNADIHYFIMSGNEQGKFKMDSTTGDLVLNATLDYEMSKFYFLTIQAIDG 3353
            |:.|..:.|:..|:|.||.|.|.:.....|  |::|:.:|.:.|.|.||||....|.|.|.|.|.
  Rat   865 GSTVVVISASDDDVGENARITYLLEDNLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITARDN 927

  Fly  3354 GTPPLSNNAYVNISILDINDNSPTFLQNLYRINVNEDIFVGSKILDVKATDEDSDVNGLVTYNIE 3418
            |.|..::..||.:.:.|:|||:|.|:.:.|...|:||....:.:|.:.|||.|:..||.|.|..:
  Rat   928 GIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQ 992

  Fly  3419 RG-DNIGQFSIDPKNGTISVSRPLDRETISHYTLEIQACDQGDPQRCNSVPININILDTNDNAPI 3482
            .| |..|.|:|:|.:|.:...|.||||.:..|.|...|.|:|.|.....|.|.:.:.|.|||||:
  Rat   993 NGEDGDGDFTIEPTSGIVRTVRRLDREAVPVYELTAYAVDRGVPPLRTPVSIQVTVQDVNDNAPV 1057

  Fly  3483 FSSSNYSVVLQENRLLGYVFLTFKISDADETPNTTPYTFDIRSGNEGGLFRLE-QDGSLRTASRF 3546
            |.:..:.|.::||.::|.|.......|.|:.|| ....:.|..||...||::: ..|.|......
  Rat  1058 FPAEEFEVRVKENSIVGSVVAQITAVDPDDGPN-AHIMYQIVEGNIPELFQMDIFSGELTALIDL 1121

  Fly  3547 NHNLQDEFVIQVRVFDNGTPPLYSDAWVVVKIIEESQYPPIVTPLEVTINSF----EDDFSGAFI 3607
            ::..:.|:||.|:.   .:.||.|.|.|.|::::::...|::...::..|::    .|.|....|
  Rat  1122 DYEARQEYVIVVQA---TSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGII 1183

  Fly  3608 GKVHASDQDKYDELNFSLVSGPDDMYQSSKLFNISNNTGKIYAISNLDIG---LYKLNVSVSDGK 3669
            |::.|.|.|..|.|.:|...|     ...:|..::..:|::.....||..   :..:.|:|:||.
  Rat  1184 GRIPAYDPDVSDHLFYSFERG-----NELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGL 1243

  Fly  3670 FHVFSIVKINVELVTNDMLKESVVIRFRRISASEF---LLSHRKTFMRSIRNIMRCRQKDVILIT 3731
            ..|.:...:.|.::|.::|..|:.:|...:....|   ||.|   |:..:..::....:||.:..
  Rat  1244 HSVTAQCVLRVVIITEELLANSLTVRLENMWQERFLSPLLGH---FLEGVAAVLATPTEDVFIFN 1305

  Fly  3732 LQSDYQKASQHAVGNRRARSIDSDLNVVFAVRKQQIIP------DSDEFFTSDEIRQTLIDKKNE 3790
            :|:|..      ||.       :.|||.|:.    :.|      .:..:|:|:|:::.|..::..
  Rat  1306 IQNDTD------VGG-------TVLNVSFSA----LAPRGAGAGAAGPWFSSEELQEQLYVRRAA 1353

  Fly  3791 IENETNLVVEDVLPSTCQSNKNDCVHGECKQILQ---ILKNNVTTTFTDVISFAAPSYIPVN--- 3849
            :...:.|   ||||    .:.|.|:...|:..::   :|:.:.:..|   ::.|:..:.|:.   
  Rat  1354 LAARSLL---DVLP----FDDNVCLREPCENYMKCVSVLRFDSSAPF---LASASTLFRPIQPIA 1408

  Fly  3850 --TCVCRPGFDGKHCKETVNACSTDPCSPQRICMPSGSALGYQCVCPKGFSGTYCE--------- 3903
              .|.|.|||.|..|:..::.|.::||.....|.....  ||.|||...|:|..||         
  Rat  1409 GLRCRCPPGFTGDFCETELDLCYSNPCRNGGACARREG--GYTCVCRPRFTGEDCELDTEAGRCV 1471

  Fly  3904 ----RKSSKCSNE-------SCDMG--------LFTAVSFGGKSYAHYKINKVKAKFTLENGFSY 3949
                |....|:|.       .|..|        ...|.||...|:..::..:.:...||      
  Rat  1472 PGVCRNGGTCTNAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTL------ 1530

  Fly  3950 SLQIRTVQQTGTLLY---ASGKVDYNILEIINGAVQYRFDLGSGEGVISVS-SINISDGEWHQIS 4010
            ||...|||.:|.|.|   .:.|.|:..||::.|.|:..:..|....|:|.: ...:|||:||.:.
  Rat  1531 SLSFATVQPSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGESSTVVSPTVPGGLSDGQWHTVH 1595

  Fly  4011 LERSLNSAKVMVDNKHVSHGSAPGVNGILNIQSNDIFV----GAEVRPH---------------- 4055
            | |..|  |...|....:.|.:.....:|::...::.|    |||:..:                
  Rat  1596 L-RYYN--KPRTDALGGAQGPSKDKVAVLSVDDCNVAVALRFGAEIGNYSCAAAGVQTSSKKSLD 1657

  Fly  4056 ---PSIIG--------YEDIQRGFIGCMANIKI--AKESLPLYISGGSTIAALKRFTNVEFKCDP 4107
               |.::|        :...::.|||||.::.|  .:..:..:::...|.|..:           
  Rat  1658 LTGPLLLGGVPNLPENFPVSRKDFIGCMRDLHIDGRRVDMAAFVANNGTTAGCQ----------- 1711

  Fly  4108 SNVLVRLGICGSQPCANSGICKELDTDVFECACQPRYSGKHC----------------------- 4149
                .:...|.|.||.|.|:|.| ....|.|.|...:.||.|                       
  Rat  1712 ----AKSHFCASGPCKNGGLCSE-RWGGFSCDCPVGFGGKDCRLTMAHPYHFQGNGTLSWDFGND 1771

  Fly  4150 -----------------------EIDLDPCS------------------SGPCLF---------- 4163
                                   ::.|.|.|                  ||..:.          
  Rat  1772 MPVSVPWYLGLSFRTRATKGVLMQVQLGPHSVLLCKLDQGLLSVTLSRASGHAVHLLLDQMTVSD 1836

  Fly  4164 --------------GGRCDYH-----------------------------------------GP- 4172
                          |||..:|                                         || 
  Rat  1837 GRWHDLRLELQEEPGGRRGHHIFMVSLDFTLFQDTMAMGSELEGLKVKHLHVGGPPPSSKEEGPQ 1901

  Fly  4173 ----------------NNYSCTCPIHLSGKRCEYGKFCT-PNPCKNG-----GICEEGDGISHCM 4215
                            .:.:...|.|    |......|| .|||.:|     ..|::......|.
  Rat  1902 GLVGCIQGVWTGFTPFGSSALPPPSH----RINVEPGCTVTNPCASGPCPPHANCKDLWQTFSCT 1962

  Fly  4216 C-RGYTGPTCEIDVDECENQPCGNGATCIN---EPGSFRCICPSYLTGASC 4262
            | .||.||.|   ||.|...||.|..:|.:   .|..:.|.|.|...|..|
  Rat  1963 CWPGYYGPGC---VDACLLNPCQNQGSCRHLQGGPHGYTCDCASGYFGQHC 2010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637
Cadherin_repeat 883..976 CDD:206637
Cadherin_repeat 984..1082 CDD:206637
Cadherin_repeat 1092..1189 CDD:206637
Cadherin_repeat 1197..1295 CDD:206637
Cadherin_repeat 1303..1386 CDD:206637
Cadherin_repeat 1413..1502 CDD:206637
Cadherin_repeat 1510..1608 CDD:206637
Cadherin_repeat 1621..1713 CDD:206637
Cadherin_repeat 1724..1811 CDD:206637
Cadherin_repeat 1819..1927 CDD:206637
Cadherin_repeat 1948..2030 CDD:206637
Cadherin_repeat 2037..2136 CDD:206637
Cadherin_repeat 2144..2235 CDD:206637
Cadherin_repeat 2246..2336 CDD:206637
Cadherin_repeat 2345..2445 CDD:206637
Cadherin_repeat 2453..2545 CDD:206637
Cadherin_repeat 2555..>2633 CDD:206637
Cadherin_repeat 2658..2759 CDD:206637 9/29 (31%)
Cadherin_repeat 2774..2856 CDD:206637 26/88 (30%)
Cadherin_repeat 2865..2963 CDD:206637 34/103 (33%)
Cadherin_repeat 2974..3063 CDD:206637 29/94 (31%)
Cadherin_repeat 3072..3165 CDD:206637 25/95 (26%)
Cadherin_repeat 3173..3269 CDD:206637 32/98 (33%)
Cadherin_repeat 3277..3374 CDD:206637 33/96 (34%)
Cadherin_repeat 3383..3479 CDD:206637 35/96 (36%)
Cadherin_repeat 3488..3579 CDD:206637 26/91 (29%)
Cadherin_repeat 3590..3681 CDD:206637 21/97 (22%)
EGF_CA 3866..3903 CDD:238011 11/36 (31%)
Laminin_G_2 3953..4077 CDD:460494 38/158 (24%)
EGF_CA <4121..4150 CDD:238011 12/74 (16%)
EGF_CA 4152..4189 CDD:238011 14/136 (10%)
EGF_CA 4195..4225 CDD:238011 12/36 (33%)
EGF_CA 4227..4262 CDD:214542 12/37 (32%)
Celsr3NP_112610.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 148..187
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 205..269
Cadherin_repeat 321..420 CDD:206637 31/119 (26%)
Cadherin_repeat 428..532 CDD:206637 34/104 (33%)
Cadherin_repeat 541..638 CDD:206637 29/96 (30%)
Cadherin_repeat 646..743 CDD:206637 25/96 (26%)
Cadherin_repeat 751..845 CDD:206637 32/98 (33%)
Cadherin_repeat 853..948 CDD:206637 33/96 (34%)
Cadherin_repeat 956..1054 CDD:206637 35/97 (36%)
Cadherin_repeat 1062..1156 CDD:206637 26/97 (27%)
Cadherin_repeat 1176..1257 CDD:206637 21/85 (25%)
EGF_CA 1428..1462 CDD:238011 11/35 (31%)
EGF_CA 1472..1505 CDD:238011 5/32 (16%)
LamG 1508..1691 CDD:238058 46/191 (24%)
EGF_CA 1717..1748 CDD:238011 13/31 (42%)
LamG 1755..1911 CDD:238058 11/155 (7%)
EGF_CA 1939..1973 CDD:238011 12/36 (33%)
EGF_CA 1973..2011 CDD:238011 13/38 (34%)
Laminin_EGF <1994..2033 CDD:395007 6/17 (35%)
EGF_Lam 2030..>2054 CDD:238012
EGF_Lam 2067..>2105 CDD:238012
HormR 2117..2181 CDD:214468
GAIN 2200..2448 CDD:465137
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2356..2395
GPS 2474..2527 CDD:197639
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 2478..2528
7tm_GPCRs 2534..2787 CDD:475119
TM helix 1 2537..2561 CDD:320659
TM helix 2 2570..2591 CDD:320659
TM helix 3 2601..2623 CDD:320659
TM helix 4 2642..2658 CDD:320659
TM helix 5 2677..2700 CDD:320659
TM helix 6 2723..2745 CDD:320659
TM helix 7 2749..2774 CDD:320659
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2887..2927
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2977..3004
Atrophin-1 <3089..>3311 CDD:460830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3091..3242
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3255..3313
Blue background indicates that the domain is not in the aligned region.

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