Protein Alignment kug and FAT4

DIOPT Version :10

• Sequence 1: NP_001027138.2
• Gene: kug / 40191
• FlyBaseID: FBgn0261574
• Length: 4699
• Species: Drosophila melanogaster
• Sequence 2: NP_001278232.1
• Gene: FAT4 / 79633
• HGNCID: 23109
• Length: 4983
• Species: Homo sapiens
• Alignment Length: 197
• Identity: 29/197 - (14%)
• Similarity: 61/197 - (30%)
• Gaps: 83/197 - (42%)

  Fly    41 WEKFSSF--------------SPNKYLEE----------VEKCATAGSVAQKKAYFESHYKKIAE 81
            |||..:|              |...::.|          ||||..|.:: .:.|:.|..:....:
Human    36 WEKVCNFQAKPDDLILATYPKSGTTWMHEILDMILNDGDVEKCKRAQTL-DRHAFLELKFPHKEK 99

  Fly    82 RRADIIMEQE-----------------------KLL----------------ERNASFRPNIQNR 107
            ...:.::|..                       |::                .|.|||.|:.||.
Human   100 PDLEFVLEMSSPQLIKTHLPSHLIPPSIWKENCKIVYVARNPKDCLVSYYHFHRMASFMPDPQNL 164

  Fly   108 ERTDDSDNDESMMIEFSTGYGSNGE---------STSEEDKLVTVIVTEVNETCNHKPLEETMDF 163
            |...:         :|.:|....|.         :..:..:::.:...::.:...|: :.:.::|
Human   165 EEFYE---------KFMSGKVVGGSWFDHVKGWWAAKDMHRILYLFYEDIKKNPKHE-IHKVLEF 219

  Fly   164 KE 165
            .|
Human   220 LE 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kug	NP_001027138.2	Cadherin_repeat	66..178	CDD:206637	18/148 (12%)
		Cadherin_repeat	187..285	CDD:206637
		Cadherin_repeat	404..503	CDD:206637
		Cadherin_repeat	513..609	CDD:206637
		Cadherin_repeat	622..708	CDD:206637
		Cadherin_repeat	776..873	CDD:206637
		Cadherin_repeat	883..976	CDD:206637
		Cadherin_repeat	984..1082	CDD:206637
		Cadherin_repeat	1092..1189	CDD:206637
		Cadherin_repeat	1197..1295	CDD:206637
		Cadherin_repeat	1303..1386	CDD:206637
		Cadherin_repeat	1413..1502	CDD:206637
		Cadherin_repeat	1510..1608	CDD:206637
		Cadherin_repeat	1621..1713	CDD:206637
		Cadherin_repeat	1724..1811	CDD:206637
		Cadherin_repeat	1819..1927	CDD:206637
		Cadherin_repeat	1948..2030	CDD:206637
		Cadherin_repeat	2037..2136	CDD:206637
		Cadherin_repeat	2144..2235	CDD:206637
		Cadherin_repeat	2246..2336	CDD:206637
		Cadherin_repeat	2345..2445	CDD:206637
		Cadherin_repeat	2453..2545	CDD:206637
		Cadherin_repeat	2555..>2633	CDD:206637
		Cadherin_repeat	2658..2759	CDD:206637
		Cadherin_repeat	2774..2856	CDD:206637
		Cadherin_repeat	2865..2963	CDD:206637
		Cadherin_repeat	2974..3063	CDD:206637
		Cadherin_repeat	3072..3165	CDD:206637
		Cadherin_repeat	3173..3269	CDD:206637
		Cadherin_repeat	3277..3374	CDD:206637
		Cadherin_repeat	3383..3479	CDD:206637
		Cadherin_repeat	3488..3579	CDD:206637
		Cadherin_repeat	3590..3681	CDD:206637
		EGF_CA	3866..3903	CDD:238011
		Laminin_G_2	3953..4077	CDD:460494
		EGF_CA	<4121..4150	CDD:238011
		EGF_CA	4152..4189	CDD:238011
		EGF_CA	4195..4225	CDD:238011
		EGF_CA	4227..4262	CDD:214542
FAT4	NP_001278232.1	Cadherin_repeat	48..131	CDD:206637	10/83 (12%)
		Cadherin_repeat	139..246	CDD:206637	14/93 (15%)
		Cadherin_repeat	254..349	CDD:206637
		Cadherin_repeat	364..471	CDD:206637
		Cadherin_repeat	479..577	CDD:206637
		Cadherin_repeat	588..685	CDD:206637
		Cadherin_repeat	693..789	CDD:206637
		Cadherin_repeat	798..889	CDD:206637
		Cadherin_repeat	899..992	CDD:206637
		Cadherin_repeat	1000..1096	CDD:206637
		Cadherin_repeat	1105..1206	CDD:206637
		Cadherin_repeat	1215..1311	CDD:206637
		Cadherin_repeat	1321..1416	CDD:206637
		Cadherin_repeat	1428..1525	CDD:206637
		Cadherin_repeat	1540..1622	CDD:206637
		Cadherin_repeat	1634..1736	CDD:206637
		Cadherin_repeat	1747..1837	CDD:206637
		Cadherin_repeat	1845..1940	CDD:206637
		Cadherin_repeat	1948..2047	CDD:206637
		Cadherin_repeat	2057..2150	CDD:206637
		Cadherin_repeat	2159..2254	CDD:206637
		Cadherin_repeat	2263..2360	CDD:206637
		Cadherin_repeat	2369..2464	CDD:206637
		Cadherin_repeat	2472..2559	CDD:206637
		Cadherin_repeat	2573..2667	CDD:206637
		Cadherin_repeat	2675..2771	CDD:206637
		Cadherin_repeat	2778..2870	CDD:206637
		Cadherin_repeat	2878..2981	CDD:206637
		Cadherin_repeat	2990..3085	CDD:206637
		Cadherin_repeat	3095..3192	CDD:206637
		Cadherin_repeat	3201..3295	CDD:206637
		Cadherin_repeat	3305..3402	CDD:206637
		Cadherin_repeat	3410..3508	CDD:206637
		Cadherin_repeat	3516..3612	CDD:206637
		EGF_CA	3864..3900	CDD:238011
		EGF_CA	3902..3938	CDD:238011
		EGF_CA	3941..3976	CDD:238011
		LamG	3979..4142	CDD:238058
		EGF	4168..4198	CDD:394967
		LamG	4247..4368	CDD:238058
		EGF_CA	4431..4465	CDD:238011