DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kug and Cdhr4

DIOPT Version :9

Sequence 1:	NP_001027138.2	Gene:	kug / 40191	FlyBaseID:	FBgn0261574	Length:	4699	Species:	Drosophila melanogaster
Sequence 2:	NP_001365320.1	Gene:	Cdhr4 / 69398	MGIID:	1916648	Length:	783	Species:	Mus musculus

Alignment Length:	787	Identity:	151/787 - (19%)
Similarity:	271/787 - (34%)	Gaps:	235/787 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1271 ISDNGSP--VL------SSTSRIVVSVLDIND-----NSPEF--DQRVYKVQVPSSATVNQSIFQ 1320
            ||:|..|  ||      .|:....:.:|.:..     |.|..  |:.||.|.|..|::.......
Mouse    27 ISENNGPGTVLRPFSFNCSSYMPTLELLSVRPPTSFFNKPSMHGDKGVYLVMVSLSSSARLDALA 91

  Fly  1321 VHAIDSDSGENGRITYSIKSGKGKNKFRIDSQR--GHIHIAKPLDSDNEFEIHIKAEDNGIPKKS 1383
            |                       |::.:..|.  |:..:      |....:|:: .|.|
Mouse    92 V-----------------------NQYELQLQYRCGNFVV------DGSIFVHVQ-RDPG----- 121

  Fly  1384 QTARVNIVVVPVNPNSQNAPLIVRKTSENVVDLTENDKPGFLVTQILAVDDDNDQLWYNISNGND 1448
               |:.......:|..:            .:.:.|...||.||..:|.......|:  ||::..:
Mouse   122 ---RIRCTGAFASPAGE------------FIYVPETITPGALVYTLLLPGVQRAQI--NITSAQN 169

  Fly  1449 DNTFYIGQDNGNILL--SKYLDYETQQSYNLTISVT-DGTFTAFTNLLVQVIDINDNPPQFAKDV 1510
            .:......|...:|.  |:.|..:.|:::.|.|||: :...:....|.|:|:....:...|.:..
Mouse   170 PSPGPFSIDEQGLLRAPSQGLRGQAQKTFQLQISVSFEKNQSCRGMLTVKVLPAPSSQVSFLQKA 234

  Fly  1511 YHVNISENIEEESVIMQLHATDRDEDKKLFYHLHATQDPSSLALFRIDSISGNVIVTQRLDFEKT 1575
            ..:.|||::...|.::::.||.       |..|:....|.....:.|....|.|..|..||..:
Mouse   235 QSITISEDLVPGSEVVRVQATG-------FNLLYEIISPRPSLFYSIGQADGVVRTTAPLDLAR- 291

  Fly  1576 AQHILIVFVKDQGAPGKRNYAKII----VNVHDHNDHHPEFTAKIIQSKVPESAAIGSKLAEVRA 1636
            .|..::..::.:.....|.:|..:    |:|...|...|.....::.:::||::.:|:.|..:..
Mouse   292 VQGAMVTKLQVRAFERPRPWASAVFDLTVSVRAVNQWPPRCHPALLVTQIPETSLVGTVLDALTC 356

  Fly  1637 IDRDSGHNAEIQYSIITGNVGSVFEIDPTFGIITLAGN-LNINKIQ---------EYMLQVKAVD 1691
            :|.||. ...:.|.:       .|...|....:.|... |.:|...         ::...:..||
Mouse   357 VDPDSA-GRPLDYQL-------RFHSPPDSASLRLRDRILEVNATLDCDTPGACFQHSASILVVD 413

  Fly  1692 LGNPPLSSQIPVHIIVTMSENDPPKFPTNNIAIEIFENLPIGTFVTQVTARSSSSIFFNIISGNI 1756
            .|.|.::::|||.::||                      |:..|......|
Mouse   414 GGQPQMTTEIPVLVMVT----------------------PVNEFSPACVPR-------------- 442

  Fly  1757 NESFRINPSTGVIVINGNIDYESIKVFNLTVKGTNMAAESSCQNIIIHILDANDNIPYFVQNEYV 1821
              :||:...||...:.|:|            .||:|                          :|
Mouse   443 --TFRVQEDTGPHTLLGSI------------VGTDM--------------------------DY- 466

  Fly  1822 GALPESAAIGSYVLKVHDSSKDHLTLQVKDADVGVNGMVEYHIVDDLAKNFFKIDSTTGAIELLR 1886
               |.::                               :||:|..  ..:.|.:|..:|.:.||.
Mouse   467 ---PRNS-------------------------------LEYYISG--GPSTFAVDRLSGELHLLG 495

  Fly  1887 QLDYETNAGYTFDVTVSDMGKP---KLHSTTTAHVTIRVINVND----CPPVFNERELNVTLFLP 1944
            .||||....|...:.:.|..:.   ..|.:.:..:||.|.:|||    |.|.|.|    :|::.|
Mouse   496 PLDYEQQRLYKITILLIDHSQDWDLNSHRSGSCTITIEVEDVNDHAPECEPPFQE----LTIYTP 556

  Fly  1945 TFENVFVRQVSA---KDADNDTLRFDIVDGNTNECFQIEKYTGIITTRNFEILN---NENDRDYA 2003
            ...::.|.:||.   ::....||.:.||.||:...|:::   |.|...|..:|.   .|....|.
Mouse   557 MGHSMEVTKVSCWIPQEPQRLTLSYSIVGGNSQSRFRLQ---GAILVYNDTVLGPPWPEQPCTYE 618

  Fly  2004 LHVRASD 2010
            |.:..:|
Mouse   619 LLIHVAD 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kug	NP_001027138.2	Cadherin_repeat	66..178	CDD:206637
		Cadherin_repeat	187..285	CDD:206637
		E_set	309..390	CDD:298831
		Cadherin_repeat	404..503	CDD:206637
		Cadherin_repeat	513..609	CDD:206637
		Cadherin_repeat	622..708	CDD:206637
		Cadherin_repeat	776..873	CDD:206637
		Cadherin_repeat	883..976	CDD:206637
		Cadherin_repeat	984..1082	CDD:206637
		Cadherin_repeat	1092..1189	CDD:206637
		Cadherin_repeat	1197..1295	CDD:206637	8/36 (22%)
		Cadherin_repeat	1303..1386	CDD:206637	13/84 (15%)
		Cadherin_repeat	1413..1502	CDD:206637	21/91 (23%)
		Cadherin_repeat	1510..1608	CDD:206637	21/101 (21%)
		Cadherin_repeat	1621..1713	CDD:206637	22/101 (22%)
		Cadherin_repeat	1724..1811	CDD:206637	12/86 (14%)
		Cadherin_repeat	1819..1927	CDD:206637	21/110 (19%)
		Cadherin_repeat	1948..2030	CDD:206637	18/69 (26%)
		Cadherin_repeat	2037..2136	CDD:206637
		Cadherin_repeat	2144..2235	CDD:206637
		Cadherin_repeat	2246..2336	CDD:206637
		Cadherin_repeat	2345..2445	CDD:206637
		Cadherin_repeat	2453..2545	CDD:206637
		Cadherin_repeat	2555..>2633	CDD:206637
		Cadherin_repeat	2658..2759	CDD:206637
		Cadherin_repeat	2774..2856	CDD:206637
		Cadherin_repeat	2865..2963	CDD:206637
		Cadherin_repeat	2974..3063	CDD:206637
		Cadherin_repeat	3072..3165	CDD:206637
		Cadherin_repeat	3173..3269	CDD:206637
		Cadherin_repeat	3277..3374	CDD:206637
		Cadherin_repeat	3383..3479	CDD:206637
		Cadherin_repeat	3488..3579	CDD:206637
		Cadherin_repeat	3590..3681	CDD:206637
		EGF_CA	3866..3903	CDD:238011
		Laminin_G_2	3953..4077	CDD:280389
		EGF_CA	<4121..4150	CDD:238011
		EGF_CA	4152..4189	CDD:238011
		EGF_CA	4195..4225	CDD:238011
		EGF_CA	4227..4262	CDD:214542
Cdhr4	NP_001365320.1	Cadherin_repeat	236..326	CDD:206637	20/97 (21%)
		Cadherin_repeat	338..434	CDD:206637	23/125 (18%)
		Cadherin_repeat	441..540	CDD:206637	32/189 (17%)
		Cadherin_repeat	555..644	CDD:206637	19/74 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900