Protein Alignment kug and Pcdhb20

DIOPT Version :10

• Sequence 1: NP_001027138.2
• Gene: kug / 40191
• FlyBaseID: FBgn0261574
• Length: 4699
• Species: Drosophila melanogaster
• Sequence 2: NP_001102865.1
• Gene: Pcdhb20 / 680203
• RGDID: 1594228
• Length: 799
• Species: Rattus norvegicus
• Alignment Length: 822
• Identity: 211/822 - (25%)
• Similarity: 335/822 - (40%)
• Gaps: 193/822 - (23%)

  Fly   780 SINESVQLGETVAWIEAKDRDLG---YNGKLVFAISDGDYDSVFRIDPDRGELQIIGYLDRERQN 841
            |:.|..::|..||.: |:|..||   .:.:....:|| |......::...|::.:...||||
  Rat    34 SVAEETEIGSFVANL-ARDLGLGVAELSSREARIVSD-DNKKHLLLNLLTGDVLLSERLDRE--- 93

  Fly   842 EYVLNITVYDLGNPTKSTSKMLPITIL---------------DVNDNRPVIQKTLATFRLTESAR 891
                     :|...|:..  :||..::               |:||:.|.......|.::.|||.
  Rat    94 ---------ELCGSTEPC--VLPFQVVLEDPLQFYRAELHVRDINDHAPTFLDKEITIKIPESAA 147

  Fly   892 IGTVVHCLHATDADSGINAQVTYALSVECSDFTVNATTGC------LRLNKPLDREKQDNYALHI 950
            ||......:|.|.|.|.|:...|::|.....:.....:|.      |.|:|.||.|::....|.:
  Rat   148 IGATFLIENAQDLDIGSNSLQDYSISPSSHFYVKIHESGDGKIYPELVLDKALDHEEESELRLTL 212

  Fly   951 TAKDGGSPVLSSEALVYVLVDDVNDNAPVFGVQEYIFKVREDLPRGTVLAVIEAVDEDIGPNAEI 1015
            ||.|||||..|...||.:.|.|:|||||.|....|..:|.||.|.|:.:..|.|.|.|:|...:|
  Rat   213 TALDGGSPPRSGTTLVLIKVLDINDNAPEFAQNFYEVQVPEDTPIGSSIITISAKDLDMGNYGKI 277

  Fly  1016 QFSLKEETQD-EELFRIDKHTGAIRTQGYLDYENKQVHNLIVSAIDGGDPSLTSDMSIVIMIIDV 1079
            .:|....|:| .:.|.|:..:|.:..:..||:|..|.:::.:.|.|||  .|::..::.:.::|:
  Rat   278 SYSFLHATEDVRKTFEINPTSGEVNLRSLLDFEVIQSYSVTIQATDGG--GLSAKCTLSVKVLDI 340

  Fly  1080 NENRFAPEFDDFVYEGKVKENKPKG---TFVMNVTARDMDTVDLNSKITYSITGGDGLGIFAVND 1141
            |:|  |||    |....|.:..|:.   |.:...:.||.|:                      .|
  Rat   341 NDN--APE----VIISSVTKTIPENASETLITLFSVRDQDS----------------------GD 377

  Fly  1142 QGSITSLSQLDAETKNFYWLTLCAQDCAIVPLSNCVEVYIQVENENDNIPLTDKPVYYVNVTEAS 1206
            .|.|                 ||:     :|               |::|...||
  Rat   378 NGRI-----------------LCS-----IP---------------DDLPFILKP---------- 395

  Fly  1207 VENVEIITLKAFDPDIDPTQTITYNIVSGNLVGYFEIDSKTGVIKTTERKLDRENQAEHILEVAI 1271
                   |.|.|           :.::|                   |:.||||::||:.:.:.:
  Rat   396 -------TFKNF-----------FTLLS-------------------EKALDRESRAEYNITITV 423

  Fly  1272 SDNGSPVLSSTSRIVVSVLDINDNSPEFDQRVYKVQVPSSATVNQSIFQVHAIDSDSGENGRITY 1336
            ||.|:|.|::...|.|.|.|||||:|.|.|..|.:.|..:.:....|..:.|.|||||.|..|||
  Rat   424 SDLGTPRLTTQHTITVQVSDINDNAPAFTQTSYTMFVHENNSPALHIGTISATDSDSGSNAHITY 488

  Fly  1337 SIKSGKG-----KNKFRIDSQRGHIHIAKPLDSD--NEFEIHIKAEDNGIPKKSQTARVNIVVVP 1394
            |:...:.     .:...|::..|.:...:.||.:  ..||..:.|.|.|.|..|..|.|.:||:.
  Rat   489 SLMPPRDPQLALDSLISINADNGQLFALRALDYEVLQAFEFRVGATDRGSPALSSQALVRVVVLD 553

  Fly  1395 VNPNSQNAPLIVRKTSENVVDLTE----NDKPGFLVTQILAVDDDNDQ---LWYNISNGNDDNTF 1452
            .|   .|||.::..........||    ..:||:|||:::|||.|:.|   |.:.:....:...|
  Rat   554 DN---DNAPFVLYPLQNASAPYTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLF 615

  Fly  1453 YIGQDNGNILLSKYLDYETQQSYNLTISVTDGTFTAFTNLLVQVIDINDNPPQFAKDVYHVNISE 1517
            .:...||.:..|:.|.......:.|.:.|.|                |.:||:.|..:.||.:.:
  Rat   616 SVWAHNGEVRTSRLLSERDAPKHKLLLMVKD----------------NGDPPRSASVMLHVLVVD 664

  Fly  1518 NIEEESVIMQ--LHATDRDEDKKLFYHLHATQDPSSLALFRI 1557
            ...:..:.:.  .|....|||....|.:.|....|||.|..:
  Rat   665 GFSQPYLPLPEVAHNPAHDEDTLTLYLVIALASVSSLFLLSV 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kug	NP_001027138.2	Cadherin_repeat	66..178	CDD:206637
		Cadherin_repeat	187..285	CDD:206637
		Cadherin_repeat	404..503	CDD:206637
		Cadherin_repeat	513..609	CDD:206637
		Cadherin_repeat	622..708	CDD:206637
		Cadherin_repeat	776..873	CDD:206637	23/110 (21%)
		Cadherin_repeat	883..976	CDD:206637	34/98 (35%)
		Cadherin_repeat	984..1082	CDD:206637	29/98 (30%)
		Cadherin_repeat	1092..1189	CDD:206637	13/99 (13%)
		Cadherin_repeat	1197..1295	CDD:206637	22/97 (23%)
		Cadherin_repeat	1303..1386	CDD:206637	25/89 (28%)
		Cadherin_repeat	1413..1502	CDD:206637	22/95 (23%)
		Cadherin_repeat	1510..1608	CDD:206637	12/50 (24%)
		Cadherin_repeat	1621..1713	CDD:206637
		Cadherin_repeat	1724..1811	CDD:206637
		Cadherin_repeat	1819..1927	CDD:206637
		Cadherin_repeat	1948..2030	CDD:206637
		Cadherin_repeat	2037..2136	CDD:206637
		Cadherin_repeat	2144..2235	CDD:206637
		Cadherin_repeat	2246..2336	CDD:206637
		Cadherin_repeat	2345..2445	CDD:206637
		Cadherin_repeat	2453..2545	CDD:206637
		Cadherin_repeat	2555..>2633	CDD:206637
		Cadherin_repeat	2658..2759	CDD:206637
		Cadherin_repeat	2774..2856	CDD:206637
		Cadherin_repeat	2865..2963	CDD:206637
		Cadherin_repeat	2974..3063	CDD:206637
		Cadherin_repeat	3072..3165	CDD:206637
		Cadherin_repeat	3173..3269	CDD:206637
		Cadherin_repeat	3277..3374	CDD:206637
		Cadherin_repeat	3383..3479	CDD:206637
		Cadherin_repeat	3488..3579	CDD:206637
		Cadherin_repeat	3590..3681	CDD:206637
		EGF_CA	3866..3903	CDD:238011
		Laminin_G_2	3953..4077	CDD:460494
		EGF_CA	<4121..4150	CDD:238011
		EGF_CA	4152..4189	CDD:238011
		EGF_CA	4195..4225	CDD:238011
		EGF_CA	4227..4262	CDD:214542
Pcdhb20	NP_001102865.1	Cadherin_2	30..112	CDD:462413	21/93 (23%)
		Cadherin_repeat	137..238	CDD:206637	34/100 (34%)
		Cadherin_repeat	247..343	CDD:206637	29/97 (30%)
		Cadherin_repeat	355..447	CDD:206637	37/197 (19%)
		Cadherin_repeat	455..557	CDD:206637	30/104 (29%)
		Cadherin_repeat	571..664	CDD:206637	27/108 (25%)
		Cadherin_C_2	687..769	CDD:465139	6/20 (30%)