DRSC/TRiP Functional Genomics Resources

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Protein Alignment kug and PCDH20

DIOPT Version :10

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:NP_073754.2 Gene:PCDH20 / 64881 HGNCID:14257 Length:951 Species:Homo sapiens


Alignment Length:845 Identity:224/845 - (26%)
Similarity:368/845 - (43%) Gaps:106/845 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly  2697 SNDKAVKDVIEINE-KTGDIVFKSKAESYGVNSYQFFVRASDRGEPQFHSEVPVSIEIIETDANI 2760
            |..:|.:.:..:|| ....::..|.||     ..:...|::.|.:||  |::|            
Human    61 SYSRATELLYSLNEGLPAGVLIGSLAE-----DLRLLPRSAGRPDPQ--SQLP------------ 106

  Fly  2761 PTFEKSSVLLKIIESTPPGTVLTKLHMIGNYTFKFSIAAD--QDHFMISD--SGEL-ILQQTLDR 2820
               |::..     |..||              ..||:|:.  ...::..|  |||| ...|.:||
Human   107 ---ERTGA-----EWNPP--------------LSFSLASRGLSGQYVTLDNRSGELHTSAQEIDR 149

  Fly  2821 E-------------------QQESHNLIVVAETSTVP-VFFAYADVLIDVRDENDNYPKFDNTFY 2865
            |                   ...|.:.:::.:...:| .:|.:..|.|.:||.|||.|:|..:..
Human   150 EALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQI 214

  Fly  2866 SASVAENSEKVISL-VKVSATDADTGPNGDIRYYLESDTENIQNIFDIDIYSG-------WITLL 2922
            |..|.||:.....| ::..|.|.|.|.||...|.|    .:...:|.:|:...       ::.::
Human   215 SVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRL----LDYHGMFTLDVEENENGERTPYLIVM 275

  Fly  2923 TSLDREVQSEYNFKVIAADNGHPKHDAKVPVTIKIVDYNDNAPVFKLPIEGLSVFENALPGTVLI 2987
            .:||||.|.:|...:||.|.|.|.......:||.|.|.|||.|:|......::|:.||..||.:.
Human   276 GALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIA 340

  Fly  2988 NLLLIDPDI-EKQEMDFFIVSGDKQAQ---FQIGK-SGELFIAKPLDREQLMFYNLSIIAT-DGK 3046
            .:..:|.|: ...::.:.......||.   |.:.: :|.:.:...:....|..:.|:|:|. .|.
Human   341 AVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGC 405

  Fly  3047 FTAKANVEIDVKDINDNTPYCLKPRYHISTNESI-------SIGTTLVEVKAIDFDFQSKLRFYL 3104
            ..|.....:.:..:....|. :.|||..:..:.:       .:.|.:......|.:.:.|:..||
Human   406 IPAVITALVSIIKVIFRPPE-IVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYL 469

  Fly  3105 SGKGADDFSIGK---ESGILKVASALDRETTPKYKLVAHVQDGKDFTQECFSEIIITVNDINDNM 3166
            .|:|....|..|   ...:|:....:|.|....|::.....:.:.|..:  ..|.:.:.|.|||.
Human   470 DGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVK--RVIKVQLLDDNDNA 532

  Fly  3167 PIFSMAQYRVSVPEDAQLNTLITKVHAMDKDFGVNRQIKYSLMGENHDYFKISKSTGIIRLHKSL 3231
            |||......:::.|:...|..:||::|.|.|.....|:.|.|..:...||.:...|||:.:...|
Human   533 PIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQL 597

  Fly  3232 DRETISLFNLTVKAEDCGVPKLHSIATVAVNILDINDNPPEFSMRQYSCKILENATHGTEVCKVY 3296
            |||....:..||:|.|||.|...|:||||:.:||.|||.|.|..:.:|..:.||.....|:..:.
Human   598 DREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVIS 662

  Fly  3297 ATSIDIGVNADIHYFIMSGNEQGKFKMDSTTGDLVLNATLDYEMSKFYFLTIQAIDGGTPPLSNN 3361
            .|..|.|.|..:...::  |:...|.:|:..|.|....:||.|....|.|.::|:|||.|.||:.
Human   663 VTDADAGRNGWVALSVV--NQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSST 725

  Fly  3362 AYVNISILDINDNSPTFL---QNLYRINVNEDIFVGSKILDVKATDEDSDVNGLVTYNI--ERGD 3421
            |.:.|.:||||||.|..|   .|:..:.|......||.:.:|.|.|:|:.:|.::.|:|  .||.
Human   726 AKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGP 790

  Fly  3422 NIGQFSIDPKNGTISVSRPLDRETISHYTLEIQACDQGDPQRCNS-VPININILDTNDNAPIFSS 3485
            ....|.||||.|.|::...|.:.....:.|.::..|.|.|:..:| |.:|:.:.||..|.....|
Human   791 RPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIES 855

  Fly  3486  3485
            Human   856  855

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637
Cadherin_repeat 883..976 CDD:206637
Cadherin_repeat 984..1082 CDD:206637
Cadherin_repeat 1092..1189 CDD:206637
Cadherin_repeat 1197..1295 CDD:206637
Cadherin_repeat 1303..1386 CDD:206637
Cadherin_repeat 1413..1502 CDD:206637
Cadherin_repeat 1510..1608 CDD:206637
Cadherin_repeat 1621..1713 CDD:206637
Cadherin_repeat 1724..1811 CDD:206637
Cadherin_repeat 1819..1927 CDD:206637
Cadherin_repeat 1948..2030 CDD:206637
Cadherin_repeat 2037..2136 CDD:206637
Cadherin_repeat 2144..2235 CDD:206637
Cadherin_repeat 2246..2336 CDD:206637
Cadherin_repeat 2345..2445 CDD:206637
Cadherin_repeat 2453..2545 CDD:206637
Cadherin_repeat 2555..>2633 CDD:206637
Cadherin_repeat 2658..2759 CDD:206637 13/62 (21%)
Cadherin_repeat 2774..2856 CDD:206637 23/106 (22%)
Cadherin_repeat 2865..2963 CDD:206637 31/105 (30%)
Cadherin_repeat 2974..3063 CDD:206637 17/94 (18%)
Cadherin_repeat 3072..3165 CDD:206637 18/102 (18%)
Cadherin_repeat 3173..3269 CDD:206637 34/95 (36%)
Cadherin_repeat 3277..3374 CDD:206637 31/96 (32%)
Cadherin_repeat 3383..3479 CDD:206637 29/98 (30%)
Cadherin_repeat 3488..3579 CDD:206637
Cadherin_repeat 3590..3681 CDD:206637
EGF_CA 3866..3903 CDD:238011
Laminin_G_2 3953..4077 CDD:460494
EGF_CA <4121..4150 CDD:238011
EGF_CA 4152..4189 CDD:238011
EGF_CA 4195..4225 CDD:238011
EGF_CA 4227..4262 CDD:214542
PCDH20NP_073754.2 Cadherin_2 70..>153 CDD:462413 27/123 (22%)
Cadherin_repeat 218..316 CDD:206637 30/101 (30%)
Cadherin_repeat 324..416 CDD:206637 17/91 (19%)
Cadherin_repeat 438..531 CDD:206637 17/94 (18%)
Cadherin_repeat 540..635 CDD:206637 34/94 (36%)
Cadherin_repeat 644..738 CDD:206637 31/95 (33%)
Cadherin_repeat 754..845 CDD:206637 27/90 (30%)
Blue background indicates that the domain is not in the aligned region.

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