Protein Alignment kug and PCDHGA5

DIOPT Version :10

• Sequence 1: NP_001027138.2
• Gene: kug / 40191
• FlyBaseID: FBgn0261574
• Length: 4699
• Species: Drosophila melanogaster
• Sequence 2: NP_061741.1
• Gene: PCDHGA5 / 56110
• HGNCID: 8703
• Length: 931
• Species: Homo sapiens
• Alignment Length: 685
• Identity: 215/685 - (31%)
• Similarity: 326/685 - (47%)
• Gaps: 50/685 - (7%)

  Fly   780 SINESVQLGETVAWIEAKD-----RDLGYNGKLVFAISDGDYDSVFRIDPDRGELQIIGYLDRER 839
            |:.|.:..|..|..| |||     ::|...|  |..:|.| ...:|.::|..|.|...|.:|||.
Human    34 SMPEELDKGSFVGNI-AKDLGLEPQELAERG--VRIVSRG-RTQLFALNPRSGSLVTAGRIDREE 94

  Fly   840 ---QNEY-VLNITVYDLGNPTKSTSKMLPITILDVNDNRPVIQKTLATFRLTESARIGTVVHCLH 900
               |:.. |:|..:. :.|..|...  :.:.|:|:|||.|..:......::.|:|..||.:....
Human    95 LCAQSPLCVVNFNIL-VENKMKIYG--VEVEIIDINDNFPRFRDEELKVKVNENAAAGTRLVLPF 156

  Fly   901 ATDADSGINAQVTYALSVECSDFTVNATTGC-------LRLNKPLDREKQDNYALHITAKDGGSP 958
            |.|||.|:|:..:|.||... .|:::..:|.       |.|.:||||||:..:.|.:||.|||.|
Human   157 ARDADVGVNSLRSYQLSSNL-HFSLDVVSGTDGQKYPELVLEQPLDREKETVHDLLLTALDGGDP 220

  Fly   959 VLSSEALVYVLVDDVNDNAPVFGVQEYIFKVREDLPRGTVLAVIEAVDEDIGPNAEIQFSLK-EE 1022
            |||....:.|.|.|.|||||:|...||...|.|::|.||.|.::.|.|.|.|.|.::.:|.: ||
Human   221 VLSGTTHIRVTVLDANDNAPLFTPSEYSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEE 285

  Fly  1023 TQDEELFRIDKHTGAIRTQGYLDYENKQVHNLIVSAIDGGDPSLTSDMSIVIMIIDVNENRFAPE 1087
            .:..|.|::|.:.|.|.|...||||..:.:.:.|.|.|||  :|.:...:|:.:.|||:|  |||
Human   286 EKISETFQLDSNLGEISTLQSLDYEESRFYLMEVVAQDGG--ALVASAKVVVTVQDVNDN--APE 346

  Fly  1088 FDDFVYEGKVKENKPKGTFVMNVTARDMDTVDLNSKITYSITGGDGLGI-FAVNDQGSITSLSQL 1151
            .........:.|:...||.:...:..|.|:.: |.:|..||.......: .:|::...:.:...|
Human   347 VILTSLTSSISEDCLPGTVIALFSVHDGDSGE-NGEIACSIPRNLPFKLEKSVDNYYHLLTTRDL 410

  Fly  1152 DAETKNFYWLTLCAQDCAIVPLSNCVEVYIQVENENDNIPLTDKPVYYVNVTEASVENVEIITLK 1216
            |.|..:.|.:||...|....|||....:.::|.:.|||.|...:..|..:|||.:...|.|.::.
Human   411 DREETSDYNITLTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVT 475

  Fly  1217 AFDPDIDPTQTITYNIVSGNLVG-----YFEIDSKTGVIKTTERKLDRENQAEHILEVAISDNGS 1276
            |.|||......:||::......|     |..|:|.|||:... |..|.|...:..|.|..||:|:
Human   476 AHDPDSGDNARVTYSLAEDTFQGAPLSSYVSINSDTGVLYAL-RSFDYEQLRDLQLWVTASDSGN 539

  Fly  1277 PVLSSTSRIVVSVLDINDNSPEF-------DQRVYKVQVPSSATVNQSIFQVHAIDSDSGENGRI 1334
            |.|||...:.:.|||.|||:||.       |........|.||.....:.:|.|:|.|||:|..:
Human   540 PPLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWL 604

  Fly  1335 TYSIKSGKGKNKFRIDSQRGHIHIAKP-LDSDN-EFEIHIKAEDNGIPKKSQTARVNIVVVPVNP 1397
            :|.:........|.:....|.:..|:. ||.|. :..:.:..||:|.|..|.|..|.:.|....|
Human   605 SYRLLKASEPGLFAVGLHTGEVRTARALLDRDALKQSLVVAVEDHGQPPLSATFTVTVAVADRIP 669

  Fly  1398 NSQNAPLIVRKTSENVVDLTENDKPGFLVTQILAV 1432
            :.. |.|...||.   :|..:.|...:||..:.||
Human   670 DIL-ADLGSIKTP---IDPEDLDLTLYLVVAVAAV 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kug	NP_001027138.2	Cadherin_repeat	66..178	CDD:206637
		Cadherin_repeat	187..285	CDD:206637
		Cadherin_repeat	404..503	CDD:206637
		Cadherin_repeat	513..609	CDD:206637
		Cadherin_repeat	622..708	CDD:206637
		Cadherin_repeat	776..873	CDD:206637	29/101 (29%)
		Cadherin_repeat	883..976	CDD:206637	37/99 (37%)
		Cadherin_repeat	984..1082	CDD:206637	36/98 (37%)
		Cadherin_repeat	1092..1189	CDD:206637	22/97 (23%)
		Cadherin_repeat	1197..1295	CDD:206637	35/102 (34%)
		Cadherin_repeat	1303..1386	CDD:206637	22/84 (26%)
		Cadherin_repeat	1413..1502	CDD:206637	6/20 (30%)
		Cadherin_repeat	1510..1608	CDD:206637
		Cadherin_repeat	1621..1713	CDD:206637
		Cadherin_repeat	1724..1811	CDD:206637
		Cadherin_repeat	1819..1927	CDD:206637
		Cadherin_repeat	1948..2030	CDD:206637
		Cadherin_repeat	2037..2136	CDD:206637
		Cadherin_repeat	2144..2235	CDD:206637
		Cadherin_repeat	2246..2336	CDD:206637
		Cadherin_repeat	2345..2445	CDD:206637
		Cadherin_repeat	2453..2545	CDD:206637
		Cadherin_repeat	2555..>2633	CDD:206637
		Cadherin_repeat	2658..2759	CDD:206637
		Cadherin_repeat	2774..2856	CDD:206637
		Cadherin_repeat	2865..2963	CDD:206637
		Cadherin_repeat	2974..3063	CDD:206637
		Cadherin_repeat	3072..3165	CDD:206637
		Cadherin_repeat	3173..3269	CDD:206637
		Cadherin_repeat	3277..3374	CDD:206637
		Cadherin_repeat	3383..3479	CDD:206637
		Cadherin_repeat	3488..3579	CDD:206637
		Cadherin_repeat	3590..3681	CDD:206637
		EGF_CA	3866..3903	CDD:238011
		Laminin_G_2	3953..4077	CDD:460494
		EGF_CA	<4121..4150	CDD:238011
		EGF_CA	4152..4189	CDD:238011
		EGF_CA	4195..4225	CDD:238011
		EGF_CA	4227..4262	CDD:214542
PCDHGA5	NP_061741.1	Cadherin_2	30..112	CDD:462413	24/82 (29%)
		Cadherin_repeat	137..238	CDD:206637	37/101 (37%)
		Cadherin_repeat	246..343	CDD:206637	36/98 (37%)
		Cadherin_repeat	355..448	CDD:206637	22/93 (24%)
		Cadherin_repeat	456..558	CDD:206637	35/102 (34%)
		Cadherin_repeat	579..666	CDD:206637	25/86 (29%)
		Cadherin_C_2	688..772	CDD:465139	5/13 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..840
		Cadherin_tail	810..>904	CDD:435046
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	901..931