Protein Alignment kug and PCDHGA6

DIOPT Version :10

• Sequence 1: NP_001027138.2
• Gene: kug / 40191
• FlyBaseID: FBgn0261574
• Length: 4699
• Species: Drosophila melanogaster
• Sequence 2: NP_061742.1
• Gene: PCDHGA6 / 56109
• HGNCID: 8704
• Length: 932
• Species: Homo sapiens
• Alignment Length: 395
• Identity: 75/395 - (18%)
• Similarity: 134/395 - (33%)
• Gaps: 131/395 - (33%)

  Fly    56 VEKCATAGSVAQKKAYFESHYKKIAERRADIIMEQEKLLERNASFRPNIQNRERTDDSDNDESMM 120
            ||...:.....|.:.....|:.:    :..:.:.::|..:.....:..::..|..:|.|:|
Human   119 VETLDSGWLTCQTEIRLRLHFSE----KPPVSISKKKFKKSRFRVKLTLEGLEEDEDDDDD---- 175

  Fly   121 IEFSTGYGSNGESTSEEDKLVTVIVTEVNETCNHK---PLEETM----DFKECR-SSVDTGDDLS 177
                                      :|:.|..||   .||.::    :|| || |..:.|..|.
Human   176 --------------------------KVSPTVLHKMSNSLEISLISDNEFK-CRHSQPECGYGLQ 213

  Fly   178 TLKLEEKLEEIVQVEDKEKVEEVI-CMKEEVKEDVPSKDT--GEM-SETLMKETKKEKDHNPIKK 238
            .   :...|..:|..:.:.:|.:. ..:|::.|.|...|.  |.: :..|:..|..|
Human   214 P---DRWTEYSIQTMEPDNLELIFDFFEEDLSEHVVQGDVLPGHVGTACLLSSTIAE-------- 267

  Fly   239 TDKNVRTNHMRASPKSNQVTKKPVTSKVVSGRKT-------------QPSKEKSMTKATNKAASP 290
                        |.:|..:...|:.|:  :.|||             .|....||..:.:|...|
Human   268 ------------SGRSAGILTLPIMSR--NSRKTIGKVRVDFIIIKPLPGYSCSMQSSFSKYWKP 318

  Fly   291 VL------KPPGFS--TPRVSK-SASTISSMSTSRS----------SVKKESVS----------T 326
            .:      :..|.|  |.:::| ..:||:|:..:.|          .:.|:.|.          |
Human   319 RIPLDVGHRGAGNSTTTAKLAKVQENTIASLRNAASHGAAFVEFDVHLSKDFVPVVYHDLTCCLT 383

  Fly   327 LLRKKQTAPKSL---PI-SLNVDQ----SVSDPTAVPT-TRKSLIMERMGDKDIVRRAFKSFQKS 382
            :.||.:..|..|   |: .|..||    .:|..||:.| .||..:.|        ...|.|..:.
Human   384 MKRKYEADPVELFEIPVKELTFDQLQLLKLSHVTALKTKDRKQSLYE--------EENFFSENQP 440

  Fly   383 FDQMK 387
            |..:|
Human   441 FPSLK 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kug	NP_001027138.2	Cadherin_repeat	66..178	CDD:206637	20/119 (17%)
		Cadherin_repeat	187..285	CDD:206637	20/114 (18%)
		Cadherin_repeat	404..503	CDD:206637
		Cadherin_repeat	513..609	CDD:206637
		Cadherin_repeat	622..708	CDD:206637
		Cadherin_repeat	776..873	CDD:206637
		Cadherin_repeat	883..976	CDD:206637
		Cadherin_repeat	984..1082	CDD:206637
		Cadherin_repeat	1092..1189	CDD:206637
		Cadherin_repeat	1197..1295	CDD:206637
		Cadherin_repeat	1303..1386	CDD:206637
		Cadherin_repeat	1413..1502	CDD:206637
		Cadherin_repeat	1510..1608	CDD:206637
		Cadherin_repeat	1621..1713	CDD:206637
		Cadherin_repeat	1724..1811	CDD:206637
		Cadherin_repeat	1819..1927	CDD:206637
		Cadherin_repeat	1948..2030	CDD:206637
		Cadherin_repeat	2037..2136	CDD:206637
		Cadherin_repeat	2144..2235	CDD:206637
		Cadherin_repeat	2246..2336	CDD:206637
		Cadherin_repeat	2345..2445	CDD:206637
		Cadherin_repeat	2453..2545	CDD:206637
		Cadherin_repeat	2555..>2633	CDD:206637
		Cadherin_repeat	2658..2759	CDD:206637
		Cadherin_repeat	2774..2856	CDD:206637
		Cadherin_repeat	2865..2963	CDD:206637
		Cadherin_repeat	2974..3063	CDD:206637
		Cadherin_repeat	3072..3165	CDD:206637
		Cadherin_repeat	3173..3269	CDD:206637
		Cadherin_repeat	3277..3374	CDD:206637
		Cadherin_repeat	3383..3479	CDD:206637
		Cadherin_repeat	3488..3579	CDD:206637
		Cadherin_repeat	3590..3681	CDD:206637
		EGF_CA	3866..3903	CDD:238011
		Laminin_G_2	3953..4077	CDD:460494
		EGF_CA	<4121..4150	CDD:238011
		EGF_CA	4152..4189	CDD:238011
		EGF_CA	4195..4225	CDD:238011
		EGF_CA	4227..4262	CDD:214542
PCDHGA6	NP_061742.1	Cadherin_C_2	688..772	CDD:465139
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	804..841
		Cadherin_tail	811..>905	CDD:435046
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	902..932
		Cadherin_2	30..112	CDD:462413
		Cadherin_repeat	137..238	CDD:206637	22/138 (16%)
		Cadherin_repeat	246..343	CDD:206637	21/118 (18%)
		Cadherin_repeat	355..448	CDD:206637	22/99 (22%)
		Cadherin_repeat	456..558	CDD:206637
		Cadherin_repeat	579..666	CDD:206637