DRSC/TRiP Functional Genomics Resources

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Protein Alignment kug and PCDHGA7

DIOPT Version :10

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:NP_061743.1 Gene:PCDHGA7 / 56108 HGNCID:8705 Length:932 Species:Homo sapiens


Alignment Length:706 Identity:198/706 - (28%)
Similarity:318/706 - (45%) Gaps:100/706 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly  2868 SVAENSEKVISLVKVSATDADTGP----NGDIRYYLESDTENIQNIFDIDIYSGWITLLTSLDRE 2928
            ||:|.::|. |.|...|.|....|    ...:|......|:    :|.::..||.:.....:|||
Human    34 SVSEETDKG-SFVGDIAKDLGLEPRELAERGVRIISRGRTQ----LFALNQRSGSLVTAGRIDRE 93

  Fly  2929 ---VQSE---YNFKVIAADNGHPKHDAKVPVTIKIVDYNDNAPVFKLPIEGLSVFENALPGTVLI 2987
               .||.   .||.::..|..:     ..|:.::|:|.|||.|.|......:.:.||..||....
Human    94 EICAQSARCLVNFNILMEDKMN-----LYPIDVEIIDINDNVPRFLTEEINVKIMENTAPGVRFP 153

  Fly  2988 NLLLIDPDIEKQEMDFF-----------IVSGDKQAQFQIGKSGELFIAKPLDREQLMFYNLSII 3041
            .....|||:....:..:           :.|||.:.::.     ||.:.:.||||:...::|.:.
Human   154 LSEAGDPDVGTNSLQSYQLSPNRHFSLAVQSGDDETKYP-----ELVLERVLDREEERVHHLVLT 213

  Fly  3042 ATDG---KFTAKANVEIDVKDINDNTPYCLKPRYHISTNESISIGTTLVEVKAIDFD-------- 3095
            |:||   ..::.|::::.|.|:||:||....|:|.::..|::.:||.|:.|.|||.|        
Human   214 ASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVT 278

  Fly  3096 --FQSKLRFYLSGKGADDFSIGKESGILKVASALDRETTPKYKLVAHVQDGKDFTQECFSEIIIT 3158
              |:.     ::.|....|.:...:|.:.....||.|.|..|::....|||.....:  ::::||
Human   279 YSFRK-----ITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDGPGSLTK--AKVLIT 336

  Fly  3159 VNDINDNMPIFSMAQYRVSVPEDAQLNTLITKVHAMDKDFGVNRQIKYSLMGENHDYFKISKS-T 3222
            |.|:|||.|..:|.....|:|||..|.|:|...:..|:|.|.|.::..:: .||.. ||:.|| .
Human   337 VLDVNDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTI-PENLP-FKLEKSID 399

  Fly  3223 GIIRL--HKSLDRETISLFNLTVKAEDCGVPKLHSIATVAVNILDINDNPPEFSMRQYSCKILEN 3285
            ...||  .|:|||||:||:|:|:||.|.|.|.|.....:.:.:.|.|||||.|....||..|.||
Human   400 NYYRLVTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAEN 464

  Fly  3286 ATHGTEVCKVYATSIDIGVNADIHYFIMSGNEQGK-----FKMDSTTGDLVLNATLDYEMSKFYF 3345
            ...|..:..|.|...|...||.|.|.:.....||.     ..::|.||.|....:.|||..:...
Human   465 NPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQ 529

  Fly  3346 LTIQAIDGGTPPLSNNAYVNISILDINDNSPTFLQNLYRINVNEDIFV-------GSKILDVKAT 3403
            |.:.|.|.|.||||:|..:::.:||.|||.|..|......:.:..:.:       |..:..|.|.
Human   530 LRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRSAEPGYLVTKVVAV 594

  Fly  3404 DEDSDVNGLVTYNIERGDNIGQFSIDPKNGTISVSRP-LDRETISHYTLEIQACDQGDPQRCNSV 3467
            |:||..|..::|.:.:....|.|::....|.:..:|. |||:.:.. :|.:...|.|.|....:|
Human   595 DKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARALLDRDALKQ-SLVVAVQDHGQPPLSATV 658

  Fly  3468 PININILDTNDNAPIFSSSNYSVVLQENRLLGYVFLTFKISDADETPNTTPYTFDI 3523
            .:.:.:.|           :...||.:   ||.:           .|:..||.:|:
Human   659 TLTVAVAD-----------SIPEVLAD---LGSL-----------EPSDGPYNYDL 689

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637
Cadherin_repeat 883..976 CDD:206637
Cadherin_repeat 984..1082 CDD:206637
Cadherin_repeat 1092..1189 CDD:206637
Cadherin_repeat 1197..1295 CDD:206637
Cadherin_repeat 1303..1386 CDD:206637
Cadherin_repeat 1413..1502 CDD:206637
Cadherin_repeat 1510..1608 CDD:206637
Cadherin_repeat 1621..1713 CDD:206637
Cadherin_repeat 1724..1811 CDD:206637
Cadherin_repeat 1819..1927 CDD:206637
Cadherin_repeat 1948..2030 CDD:206637
Cadherin_repeat 2037..2136 CDD:206637
Cadherin_repeat 2144..2235 CDD:206637
Cadherin_repeat 2246..2336 CDD:206637
Cadherin_repeat 2345..2445 CDD:206637
Cadherin_repeat 2453..2545 CDD:206637
Cadherin_repeat 2555..>2633 CDD:206637
Cadherin_repeat 2658..2759 CDD:206637
Cadherin_repeat 2774..2856 CDD:206637
Cadherin_repeat 2865..2963 CDD:206637 26/104 (25%)
Cadherin_repeat 2974..3063 CDD:206637 24/102 (24%)
Cadherin_repeat 3072..3165 CDD:206637 27/102 (26%)
Cadherin_repeat 3173..3269 CDD:206637 37/98 (38%)
Cadherin_repeat 3277..3374 CDD:206637 34/101 (34%)
Cadherin_repeat 3383..3479 CDD:206637 21/103 (20%)
Cadherin_repeat 3488..3579 CDD:206637 8/36 (22%)
Cadherin_repeat 3590..3681 CDD:206637
EGF_CA 3866..3903 CDD:238011
Laminin_G_2 3953..4077 CDD:460494
EGF_CA <4121..4150 CDD:238011
EGF_CA 4152..4189 CDD:238011
EGF_CA 4195..4225 CDD:238011
EGF_CA 4227..4262 CDD:214542
PCDHGA7NP_061743.1 Cadherin_2 31..112 CDD:462413 21/82 (26%)
Cadherin_repeat 137..238 CDD:206637 24/105 (23%)
Cadherin_repeat 246..343 CDD:206637 27/103 (26%)
Cadherin_repeat 355..448 CDD:206637 37/94 (39%)
Cadherin_repeat 456..558 CDD:206637 34/101 (34%)
Cadherin_repeat 579..666 CDD:206637 20/87 (23%)
Cadherin_C_2 688..772 CDD:465139 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 805..841
Cadherin_tail 811..>905 CDD:435046
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 902..932
Blue background indicates that the domain is not in the aligned region.

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