Protein Alignment kug and PCDHGA11

DIOPT Version :10

• Sequence 1: NP_001027138.2
• Gene: kug / 40191
• FlyBaseID: FBgn0261574
• Length: 4699
• Species: Drosophila melanogaster
• Sequence 2: NP_061737.1
• Gene: PCDHGA11 / 56105
• HGNCID: 8698
• Length: 935
• Species: Homo sapiens
• Alignment Length: 697
• Identity: 200/697 - (28%)
• Similarity: 322/697 - (46%)
• Gaps: 74/697 - (10%)

  Fly   780 SINESVQLGETVAWIEAKD-----RDLGYNGKLVFAISDGDYDSVFRIDPDRGELQIIGYLDRER 839
            |:.|..:.|..|..| :||     |:|...|  |..:|.|. ..:|.::|..|.|...|.:|||.
Human    35 SVPEETEKGSFVGNI-SKDLGLEPRELAKRG--VRIVSRGK-TQLFAVNPRSGSLITAGRIDREE 95

  Fly   840 QNEYV----LNITVYDLGNPTKSTSKM--LPITILDVNDNRPVIQKTLATFRLTESARIGTVVHC 898
            ..|.|    ||:.:.     .:.|.|:  :.:.|:|:|||.|..|:.....:::|.|..|.....
Human    96 LCETVSSCFLNMELL-----VEDTLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFAL 155

  Fly   899 LHATDADSGINAQVTYAL------SVECSDFTVNATTGCLRLNKPLDREKQDNYALHITAKDGGS 957
            .:|.|.|.|:|:..:|.|      |::....|..|....|.|...|||||:..:.|.:||.|||.
Human   156 PNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGD 220

  Fly   958 PVLSSEALVYVLVDDVNDNAPVFGVQEYIFKVREDLPRGTVLAVIEAVDEDIGPNAEIQFSLKE- 1021
            |:......:.|:|.||||:.|:|....|...|.|::..||.:.::.|.|.|.|.|.|:.:|.:.
Human   221 PIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNM 285

  Fly  1022 ETQDEELFRIDKHTGAIRTQGYLDYENKQVHNLIVSAIDGGDPSLTSDMSIVIMIIDVNENRFAP 1086
            |::..|:|::|..||.::.:|.||:|..:.:.:.:...|||  .|.:..:::|.::|||:|  ||
Human   286 ESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGG--GLFTTTTMLITVVDVNDN--AP 346

  Fly  1087 EFDDFVYEGKVKENKPKGTFVMNVTARDMDTVDLNSKITYSI----------TGGDGLGIFAVND 1141
            |.........:.||.|.||.:..:..:|.|:.: |.:::..|          |.|        |.
Human   347 EITITSSINSILENSPPGTVIALLNVQDQDSGE-NGQVSCFIPNHLPFKLEKTYG--------NY 402

  Fly  1142 QGSITSLSQLDAETKNFYWLTLCAQDCAIVPLSNCVEVYIQVENENDNIPLTDKPVYYVNVTEAS 1206
            ...||| ..||.|....|.:||.|.|....|||....|::.|.::|||.|:.....|...:.|.:
Human   403 YKLITS-RVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENN 466

  Fly  1207 VENVEIITLKAFDPDIDPTQTITYNIVSGNLVG-----YFEIDSKTGVIKTTERKLDRENQAEHI 1266
            .....|.::.|.|||......:||::....:.|     |..|:|.|||:...: ..|.|...:..
Human   467 PRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQ-SFDYEQFRDLE 530

  Fly  1267 LEVAISDNGSPVLSSTSRIVVSVLDINDNSPEF-------DQRVYKVQVPSSATVNQSIFQVHAI 1324
            |.|...|:|.|.|||...:.:.|||.|||:||.       |........|.||.....:.:|.|:
Human   531 LRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAV 595

  Fly  1325 DSDSGENGRITYSIKSGKGKNKFRIDSQRGHIHIAKP-LDSDN-EFEIHIKAEDNGIPKKSQTAR 1387
            |.|||:|..::|.:........|.:....|.:..|:. ||.|. :..:.:..:|:|.|..|.|..
Human   596 DKDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVT 660

  Fly  1388 VNIVVVPVNPNSQNAPLIVRK--TSENVVDLTENDKPGFLVTQILAV 1432
            :.:.|      :.:.|.::..  :.|::.:...:|...:||..:.||
Human   661 LTVAV------ADSIPEVLADLGSLESLANSETSDLSLYLVVAVAAV 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kug	NP_001027138.2	Cadherin_repeat	66..178	CDD:206637
		Cadherin_repeat	187..285	CDD:206637
		Cadherin_repeat	404..503	CDD:206637
		Cadherin_repeat	513..609	CDD:206637
		Cadherin_repeat	622..708	CDD:206637
		Cadherin_repeat	776..873	CDD:206637	30/103 (29%)
		Cadherin_repeat	883..976	CDD:206637	32/98 (33%)
		Cadherin_repeat	984..1082	CDD:206637	30/98 (31%)
		Cadherin_repeat	1092..1189	CDD:206637	29/106 (27%)
		Cadherin_repeat	1197..1295	CDD:206637	30/102 (29%)
		Cadherin_repeat	1303..1386	CDD:206637	21/84 (25%)
		Cadherin_repeat	1413..1502	CDD:206637	5/20 (25%)
		Cadherin_repeat	1510..1608	CDD:206637
		Cadherin_repeat	1621..1713	CDD:206637
		Cadherin_repeat	1724..1811	CDD:206637
		Cadherin_repeat	1819..1927	CDD:206637
		Cadherin_repeat	1948..2030	CDD:206637
		Cadherin_repeat	2037..2136	CDD:206637
		Cadherin_repeat	2144..2235	CDD:206637
		Cadherin_repeat	2246..2336	CDD:206637
		Cadherin_repeat	2345..2445	CDD:206637
		Cadherin_repeat	2453..2545	CDD:206637
		Cadherin_repeat	2555..>2633	CDD:206637
		Cadherin_repeat	2658..2759	CDD:206637
		Cadherin_repeat	2774..2856	CDD:206637
		Cadherin_repeat	2865..2963	CDD:206637
		Cadherin_repeat	2974..3063	CDD:206637
		Cadherin_repeat	3072..3165	CDD:206637
		Cadherin_repeat	3173..3269	CDD:206637
		Cadherin_repeat	3277..3374	CDD:206637
		Cadherin_repeat	3383..3479	CDD:206637
		Cadherin_repeat	3488..3579	CDD:206637
		Cadherin_repeat	3590..3681	CDD:206637
		EGF_CA	3866..3903	CDD:238011
		Laminin_G_2	3953..4077	CDD:460494
		EGF_CA	<4121..4150	CDD:238011
		EGF_CA	4152..4189	CDD:238011
		EGF_CA	4195..4225	CDD:238011
		EGF_CA	4227..4262	CDD:214542
PCDHGA11	NP_061737.1	Cadherin_2	31..113	CDD:462413	25/86 (29%)
		Cadherin_repeat	138..239	CDD:206637	32/100 (32%)
		Cadherin_repeat	247..344	CDD:206637	30/98 (31%)
		Cadherin_repeat	356..449	CDD:206637	29/102 (28%)
		Cadherin_repeat	457..559	CDD:206637	30/102 (29%)
		Cadherin_repeat	580..667	CDD:206637	23/92 (25%)
		Cadherin_C_2	689..773	CDD:465139	5/13 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	805..844
		Cadherin_tail	814..>908	CDD:435046
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	905..935