DRSC/TRiP Functional Genomics Resources

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Protein Alignment kug and celsr1b

DIOPT Version :10

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:XP_001920772.2 Gene:celsr1b / 556520 ZFINID:ZDB-GENE-050823-4 Length:3006 Species:Danio rerio


Alignment Length:2720 Identity:623/2720 - (22%)
Similarity:991/2720 - (36%) Gaps:820/2720 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  2356 FGTQILKINATDNDSGAN-AKLS------YYIE-SINGQNNSELFYIDVTDGNLYLKTPLDYEQI 2412
            ||...|.::.| ...||| |.:|      |.|: |:..::......|..:||.|.|....|..::
Zfish    19 FGCLDLHLSET-LKPGANLANVSIGPEWTYRIDRSLTDKSFRHFLKIGRSDGLLLLARKFDCARL 82

  Fly  2413 KYHHIVVNVKDHGSPSLSSR------------SNVFITV--KDLNDNAPCFVEPSYFTKVSVAAV 2463
            ..:.:.:.::.  .|.||..            .|.:|..  |:|..:|..:|...|.:.:|:.  
Zfish    83 PRNPVPMYLRI--KPQLSENFILLHFNTFVHGQNCYIKYKRKNLTPDAYMYVVTGYDSCLSLD-- 143

  Fly  2464 RGQFVALPKAYDKDISDTDSLEYKIVYGNELQTYSIDKLTGVIS-LQNML---NFTDKSSTV--L 2522
                 :||      |:..:||...:......:...::|....:| |.|..   |..|:::.:  :
Zfish   144 -----SLP------INIYESLPVSMRNSQMFRGRCVEKTQRRVSPLTNRCLPHNQRDEANLICLM 197

  Fly  2523 NISVSDGVHTAYARLKISL---------------LPENVYS-PLFDQSTYEAQVPENLLHGHNII 2571
            ..||:..:   |..:|:.|               ...||.| |.|....|:..||||...|..:|
Zfish   198 PNSVNSSL---YVDVKLHLNRKYTGSDFDPWAKRQKRNVNSAPQFQLPNYQVSVPENEPSGTRVI 259

  Fly  2572 TVKASDGDFGTYANLYYE---IVSEEMKKIFLIDQTTGVITSKVTFDREKKDEYVVLLKVSDGG- 2632
            |:||.|.|.|....:.|:   :.......:|.|:..||.||:....|||.||.:|..:..:|.| 
Zfish   260 TLKAFDADDGDAGVVVYDMEALFDSRSNNLFQINPETGGITTLQPLDREVKDTHVFKVTATDKGI 324

  Fly  2633 -GKFGFASLKVIVVDVNDNVPYFLLKEYKMVVSTTVEANQTILTVKAKDDDIVDNGSVHFQIVQK 2696
             .:...|.|.:.|.|.||:.|.|...||::.|...||....::|::|.|.|...|.::.::||  
Zfish   325 PKRSAIAYLTITVSDTNDHSPVFEQNEYRVNVRENVEVGFEVMTIRATDGDAPSNANMIYKIV-- 387

  Fly  2697 SNDKAVKDVIEINEKTGDIVFKSKAESYGVNSYQFFVRASDRG-EPQFHSEVPVSIEIIETDANI 2760
             ||..|....||:.:.|.:..|.:.:....:.|:.||.|:|:| ||                   
Zfish   388 -NDDEVNSCFEIDPRNGLVRTKVRPDREVKSQYKLFVEANDQGREP------------------- 432

  Fly  2761 PTFEKSSVLLKIIESTPPGTVLTKLHMIGNYTFKFSIAADQDHFMISDSGELILQQTLDREQQES 2825
                            .|.|.                                            
Zfish   433 ----------------GPRTA-------------------------------------------- 437

  Fly  2826 HNLIVVAETSTVPVFFAYADVLIDVRDENDNYPKFDNTFYSASVAENSEKVISLVKVSATDADTG 2890
                    |:||.:|         :.|||||||:|....|...|:||......:..|.|||.|.|
Zfish   438 --------TATVHIF---------IEDENDNYPQFSEKRYVVQVSENIAVNTQVAVVKATDKDAG 485

  Fly  2891 PNGDIRYYLESDTENIQNIFDIDIYSGWITLLTSLDREVQSEYNFKVIAADNGHPKHDAKVP--- 2952
            .|..:.|.:.:.  ||:..|.|...:|.|.:::.||.|:..||..:|.|.|.|.|      |   
Zfish   486 NNAKVHYSIING--NIKGQFYIHSPTGVIDVVSPLDYEMIREYTLRVKAQDGGRP------PLIN 542

  Fly  2953 ----VTIKIVDYNDNAPVF-KLPIEGLSVFENALPGTVLINLLLIDPDIEKQEMDFFIVSGDKQA 3012
                |.|::||.|||||:| ..|.:. ||.||...|..:|::..||.|           |||   
Zfish   543 GTGMVVIQVVDVNDNAPMFVSTPFQA-SVLENVPIGYSVIHIQAIDAD-----------SGD--- 592

  Fly  3013 QFQIGKSGELFIAKPLDREQLMFYNLSIIATDGKFTAKANVEIDVKDINDNTPYCLKPRYHISTN 3077
                                                 .|::|..:.|.:...|            
Zfish   593 -------------------------------------NAHLEYKLTDTSPGFP------------ 608

  Fly  3078 ESISIGTTLVEVKAIDFDFQSKLRFYLSGKGADDFSIGKESGILKVASALDRETTPKYKLVAHVQ 3142
                                              |.|...:|.:.|::.||||||..|......:
Zfish   609 ----------------------------------FVINNSTGWVTVSAELDRETTEFYSFGVEAR 639

  Fly  3143 DGKDFTQECFSEIIITVNDINDNMPIFSMAQYRVSVPEDAQLNTLITKVHAMDKDFGVNRQIKYS 3207
            |....|....:.:.:|:.|:|||:|.|:...|.:.|.|||.:.|.:..|.|:|:|  ||..:.|.
Zfish   640 DHGVPTMSSSASVSVTILDVNDNVPTFTQHLYNLKVNEDAVVGTSVLTVSAVDRD--VNSVVTYQ 702

  Fly  3208 L-MGENHDYFKISKST--GIIRLHKSLDRETISLFNLTVKAEDCGVPKLHSIATVAVNILDINDN 3269
            : .|...:.|.||..:  |:|.|...||.:....:.||:.|.|   ...|....|.:|:.|.|.:
Zfish   703 ISSGNTRNRFAISSQSGGGLITLALPLDYKQERQYLLTITASD---GTRHDTTQVFINVTDANTH 764

  Fly  3270 PPEFSMRQYSCKILENATHGTEVCKVYATSIDIGVNADIHYFIMSGNEQGKFKMDSTTGDLVLNA 3334
            .|.|....|...:.|:...|:.|..:.||..|.|.||.|.| :|..|.. :|::|..||.:....
Zfish   765 RPVFQSANYQVLVSEDRPVGSTVVVISATDEDTGENARITY-VMEDNVP-QFRIDPDTGAITTQI 827

  Fly  3335 TLDYEMSKFYFLTIQAIDGGTPPLSNNAYVNISILDINDNSPTFLQNLYRINVNEDIFVGSKILD 3399
            .:|||....|.|.|.|.|.|.|..|:..||.|.:||.|||.|.||:::|:..|.||..|.:.:|.
Zfish   828 EIDYEDQASYTLAIIARDNGIPQKSDTTYVEIIVLDANDNVPQFLRDIYQGTVFEDAPVYTSVLQ 892

  Fly  3400 VKATDEDSDVNGLVTYNIERGDN-IGQFSIDPKNGTISVSRPLDRETISHYTLEIQACDQGDPQR 3463
            |.|:|.||..||.::|..:.||: .|.|.|:|.:|.|..:|.||||.::.|||:..|.|:|.|..
Zfish   893 VSASDRDSGSNGRLSYTFQGGDDGEGDFFIEPYSGIIRTARKLDRENVALYTLKAFAVDKGVPPL 957

  Fly  3464 CNSVPININILDTNDNAPIFSSSNYSVVLQENRLLGYVFLTFKISDADETPNTTPYTFDIRSGNE 3528
            ..:|.|.:::||.|||||:|......:.::||..:|........:|.||..| ....:.|..||.
Zfish   958 KAAVDIQVSVLDINDNAPVFEKDELYIYVEENSAVGSTLARVSATDPDEGTN-AQILYQIVEGNF 1021

  Fly  3529 GGLFRLE-QDGSLRTASRFNHNLQDEFVIQVRVFDNGTPPLYSDAWVVVKIIEESQYPPIVTPLE 3592
            ..:|:|: ..|.|...:..::..:.|:||.|:.   .:.||.|.|.|.|.:::.:...|::...|
Zfish  1022 PEVFQLDIFSGDLIALTDLDYETKMEYVIVVQA---TSAPLVSRATVHVLLVDVNDNDPVLQDFE 1083

  Fly  3593 VTINSFEDDFSGAF----IGKVHASDQDKYDELNFSLVSGPDDMYQSSKLFNISNNTGKIYAISN 3653
            :..|::..:.|.:|    ||||.|.|.|..|:|.::.|.|     ....|..::.:||::....:
Zfish  1084 IIFNNYITNKSSSFPNGVIGKVPARDPDVSDKLIYTFVEG-----NELGLLILNQDTGELKLSKD 1143

  Fly  3654 LDIGL---YKLNVSVSDGKFHVFSIVKINVELVTNDMLKESVVIRFRRISASEFLLSHRKTFMRS 3715
            ||...   ..:.|:||||...|.::..:.|.::|:|||..|:.:|...:|...||......|...
Zfish  1144 LDNNRPLEALMRVTVSDGLHQVSALCTLRVTIITDDMLTNSITVRLENMSQERFLSPLLSLFAEG 1208

  Fly  3716 IRNIMRCRQKDVILITLQSDYQKASQHAVGNRRARSIDSDLNVVFAVRKQQIIPDS--DEFFTSD 3778
            :..::......:.:..:|:|...:.             |.|||.|:.    ::|..  ..:|.|:
Zfish  1209 VAAVLSTSPDGIFIFNVQNDTDVSG-------------SILNVTFSA----LLPGGAPGRYFPSE 1256

  Fly  3779 EIRQTLIDKKNEIENETNLVV---EDVLPSTCQSNKNDCVHGECKQILQ---ILKNNVTTTF--T 3835
            |:::.|      ..|.|.|::   :.|||    .:.|.|:...|:..::   :||.:.|..|  :
Zfish  1257 ELQEQL------YLNRTLLMLISTQRVLP----FDDNICLREPCENYMKCVAVLKFDSTAPFVAS 1311

  Fly  3836 DVISFAAPSYIPVN--TCVCRPGFDGKHCKETVNACSTDPCSPQRICMPSGSALGYQCVCPKGFS 3898
            :.:.| .|.: |||  .|.|..||.|.:|:..|:.|.:.||.....|.....  ||.|.||:.|:
Zfish  1312 NTVLF-RPIH-PVNGLRCRCPDGFTGDYCETEVDLCYSGPCQNNGKCRSKEG--GYTCECPQDFT 1372

  Fly  3899 GTYCE--RKSSKCSNESCDMG-------------------------LFTAVSFGGKSYAHYKINK 3936
            |..||  .:|.:|....|..|                         ..:..||.|:|:..::..:
Zfish  1373 GERCEVNARSGRCVPGVCKNGGRCLDLLVGGFMCQCPDGEYEKPYCQMSTRSFPGQSFITFRGLR 1437

  Fly  3937 VKAKFTLENGFSYSLQIRTVQQTGTLLY---ASGKVDYNILEIINGAVQYRFDLGSGEGVIS--V 3996
            .:..|||      |....|.::...|||   .:.|.|:..:||:...:|..|..|..:..::  |
Zfish  1438 QRFHFTL------SFMFATRERNALLLYNGRFNEKHDFIAIEIVKEQIQLTFSAGESKTTVTPFV 1496

  Fly  3997 SSINISDGEWHQISLERSLNSAKVMVDNKHVSHGSAPGVNGILNIQSNDIFV----GAEVRPH-- 4055
            :. .:|||:||.|.|.   ...|..:....|.||.:.....::.:...|:.:    |.::..:  
Zfish  1497 AG-GVSDGQWHTIHLH---YYNKPNIGRLGVPHGPSQEKVAVVALDDCDVAMALRFGGQIGNYSC 1557

  Fly  4056 -----------------PSIIG-----YEDI---QRGFIGCMANIKIAKESLPL----YISGGST 4091
                             |.::|     .||.   .|.|:||:.|:.|  :|.|:    :||...|
Zfish  1558 AARGTQTGQKKSLDLTGPLLVGGVPNLPEDFPVQNRDFVGCIKNLTI--DSKPIDMANFISDNGT 1620

  Fly  4092 IA--ALKRFTNVEFKCDPSNVLVRLGICGSQPCANSGICKELDTDVFECACQPRYSGKHCE---- 4150
            .|  |.||                 ..|....|.|.|:|.. ..:...|.|...|.||:||    
Zfish  1621 AAGCAAKR-----------------DFCSQAVCQNGGVCVN-RWNTHTCNCPLGYGGKNCEHVMP 1667

  Fly  4151 -------------IDLDPC---------------SSGPCL------------------------F 4163
                         .|.|..               |:|..|                        .
Zfish  1668 APLHFDGHALVSWSDTDITIAIPWYMGLMFRTRKSTGVILQATAGEFSKINLMVTNRHLRFQVFL 1732

  Fly  4164 GGR----CDYHGPNNYSCTCPIH------LSGK-----------RCEYGKF-------------- 4193
            |.|    .|:  |..|......|      .|||           ..:||.|              
Zfish  1733 GNRRVALLDF--PQVYVDNGEWHHVLVELKSGKDGKDIKYMALVSLDYGMFQRTVEIGNELPGLK 1795

  Fly  4194 ----------------------------------------------------------CTPNPCK 4200
                                                                      |..|.|.
Zfish  1796 LRNLFIGGLLKKDDTVQGGFNGCMQGVRMGETSTNIANINIRHAKRIHAKDGCNVPDACLANLCP 1860

  Fly  4201 NGGICEEGDGISH-CMCR-GYTGPTCEIDVDECENQPCGNGATCINEPGS---FRCICPSYLTGA 4260
            :...|.: :..|| |:|: ||.|..|   ||.|...||.:.::|:.:|.:   :.|.|.....|.
Zfish  1861 SHSHCTD-NWTSHTCVCQPGYFGRDC---VDACLLNPCEHTSSCVRKPSTKRGYSCDCGHNYYGQ 1921

  Fly  4261 SC-------------GDPLYSNSISTKLKNFSIEHISGIISGVAVVLVIISCVLCCVVLKRSSSS 4312
            .|             |:|                                :|..|...|.:.   
Zfish  1922 YCEHKGDQPCAHGWWGNP--------------------------------TCGPCNCDLSKG--- 1951

  Fly  4313 KRRNRLEKDKNKSSYKEANLNSLVDKDNYCKPNVKLSNLEVNQRPISYTAVPNDNLVLSNRNFVN 4377
                 .::|.||::      .....||||.:|   |.         ..|..|.|...|.:.:.| 
Zfish  1952 -----FKRDCNKTT------GECSCKDNYFRP---LG---------GDTCYPCDCFHLGSHSRV- 1992

  Fly  4378 NLDILRSY-----GSAGDELENVPFEYQKVNRNKQHVNINSC----------------------- 4414
             .|.:...     |..|.:.......:.:|......|..:.|                       
Zfish  1993 -CDPVTGQCSCKTGVVGRQCNRCDNPFAEVTVTGCVVVYDGCPKAFEEGIWWPRTMFGGPAATNC 2056

  Fly  4415 ----------HSTDADNAYKQEW--CEQMHLRTFSENKLNNELKRDFGPSVSRF------STGKL 4461
                      |.:|....:..|.  |..:   :||:.|..:|   |...:.||.      |...|
Zfish  2057 PKGSSGTAIRHCSDDKGWFPSELFNCTSL---SFSKLKKASE---DLYANASRMDGERSRSLASL 2115

  Fly  4462 IQVEMPNVCHSSSANFVDYSALANGQYHWDCSDWVRKSHNPLPDITE----VPGAEIADSSSLHS 4522
            :|          ||....|....|.         ||.:::.|..:.|    ..|.|:   ::.|.
Zfish  2116 LQ----------SATGHTYRLFGND---------VRTAYHLLASVLEHESLQQGFEL---TATHD 2158

  Fly  4523 NDSNESKSKKAFFVHREDGDVDPTRDIAALNEDIGSEYLDSEAESCLEPFMLPRSSNQPLSRLSS 4587
            .|.|.:..|..                :|:.:.:..|:.:.          :.||.....:.|..
Zfish  2159 TDFNRNIIKAG----------------SAILDPLNQEHWEK----------IQRSDGGTANLLHQ 2197

  Fly  4588 FNNIENEDYKSNTVPLPSKVSHSCKVYLRH----PDSYLPTMHFPSETDGESSMTEGPISRMEIK 4648
            |     |:| :||:     |.:..|.|||.    .|:.:..:.|.     :|:.::..|.|.: :
Zfish  2198 F-----EEY-ANTL-----VQNVRKTYLRPFTIITDNIIVALDFL-----DSTASQEKIPRFQ-E 2245

  Fly  4649 TRRTISENSEEAYLFP----------CTVGEIGSNSNISVRLCEIEDSELEEFLP 4693
            .:...|:..|.:.|||          ....:..|..|.:|.:..::.|::.:.:|
Zfish  2246 VKEVFSKEMECSVLFPNLLMSKKSKDALSTDPPSQINSTVSVMSMDGSDVVDLIP 2300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637
Cadherin_repeat 883..976 CDD:206637
Cadherin_repeat 984..1082 CDD:206637
Cadherin_repeat 1092..1189 CDD:206637
Cadherin_repeat 1197..1295 CDD:206637
Cadherin_repeat 1303..1386 CDD:206637
Cadherin_repeat 1413..1502 CDD:206637
Cadherin_repeat 1510..1608 CDD:206637
Cadherin_repeat 1621..1713 CDD:206637
Cadherin_repeat 1724..1811 CDD:206637
Cadherin_repeat 1819..1927 CDD:206637
Cadherin_repeat 1948..2030 CDD:206637
Cadherin_repeat 2037..2136 CDD:206637
Cadherin_repeat 2144..2235 CDD:206637
Cadherin_repeat 2246..2336 CDD:206637
Cadherin_repeat 2345..2445 CDD:206637 25/110 (23%)
Cadherin_repeat 2453..2545 CDD:206637 18/112 (16%)
Cadherin_repeat 2555..>2633 CDD:206637 28/82 (34%)
Cadherin_repeat 2658..2759 CDD:206637 27/101 (27%)
Cadherin_repeat 2774..2856 CDD:206637 9/81 (11%)
Cadherin_repeat 2865..2963 CDD:206637 34/104 (33%)
Cadherin_repeat 2974..3063 CDD:206637 15/88 (17%)
Cadherin_repeat 3072..3165 CDD:206637 16/92 (17%)
Cadherin_repeat 3173..3269 CDD:206637 31/98 (32%)
Cadherin_repeat 3277..3374 CDD:206637 35/96 (36%)
Cadherin_repeat 3383..3479 CDD:206637 39/96 (41%)
Cadherin_repeat 3488..3579 CDD:206637 24/91 (26%)
Cadherin_repeat 3590..3681 CDD:206637 26/97 (27%)
EGF_CA 3866..3903 CDD:238011 12/36 (33%)
Laminin_G_2 3953..4077 CDD:460494 34/159 (21%)
EGF_CA <4121..4150 CDD:238011 9/28 (32%)
EGF_CA 4152..4189 CDD:238011 14/96 (15%)
EGF_CA 4195..4225 CDD:238011 10/31 (32%)
EGF_CA 4227..4262 CDD:214542 10/37 (27%)
celsr1bXP_001920772.2 Cadherin_repeat 244..343 CDD:206637 33/98 (34%)
Cadherin_repeat 351..451 CDD:206637 36/198 (18%)
Cadherin_repeat 460..557 CDD:206637 34/104 (33%)
Cadherin_repeat 565..662 CDD:206637 33/194 (17%)
Cadherin_repeat 671..764 CDD:206637 31/97 (32%)
Cadherin_repeat 773..867 CDD:206637 35/95 (37%)
Cadherin_repeat 875..973 CDD:206637 39/97 (40%)
Cadherin_repeat 981..1075 CDD:206637 24/97 (25%)
EGF_CA 1342..1377 CDD:238011 12/36 (33%)
EGF_CA 1387..1419 CDD:214542 2/31 (6%)
LamG 1422..1605 CDD:238058 43/194 (22%)
EGF_CA 1629..1663 CDD:238011 10/34 (29%)
Laminin_G_2 1697..1827 CDD:460494 15/131 (11%)
EGF_CA 1852..1886 CDD:238011 12/37 (32%)
Laminin_EGF <1912..1946 CDD:395007 8/65 (12%)
Laminin_EGF 1944..>1978 CDD:395007 11/59 (19%)
EGF_Lam 1980..>2018 CDD:238012 7/39 (18%)
HormR 2030..2091 CDD:214468 7/63 (11%)
GAIN 2108..2359 CDD:465137 47/258 (18%)
GPS 2385..2438 CDD:197639
7tmB2_CELSR1 2443..2695 CDD:320657
TM helix 1 2445..2470 CDD:320657
TM helix 2 2479..2501 CDD:320657
TM helix 3 2510..2537 CDD:320657
TM helix 4 2549..2569 CDD:320657
TM helix 5 2586..2615 CDD:320657
TM helix 6 2626..2653 CDD:320657
TM helix 7 2657..2682 CDD:320657
Blue background indicates that the domain is not in the aligned region.

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