DRSC/TRiP Functional Genomics Resources

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Protein Alignment kug and PCDH9

DIOPT Version :10

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:NP_982354.1 Gene:PCDH9 / 5101 HGNCID:8661 Length:1237 Species:Homo sapiens


Alignment Length:1074 Identity:294/1074 - (27%)
Similarity:451/1074 - (41%) Gaps:218/1074 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   770 PEFV---NFPQELSINESVQLGETVAWIEAKDRDLGYNGKLVFAI--SDGDYDSVFRIDPDRGEL 829
            ||.|   |.|::|:|:.          |.|.   .|.:..||:.:  ..||...| ::....||:
Human    35 PENVPIGNIPKDLNISH----------INAA---TGTSASLVYRLVSKAGDAPLV-KVSSSTGEI 85

  Fly   830 -QIIGYLDRER---------QNEYVLNITVYDLGNPTKSTSKMLPITILDVNDNRPVIQKTLATF 884
             .....:|||:         :||....:.|..|.|......| :.|.:.|.|||.|:....:...
Human    86 FTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIK-IKIIVKDTNDNAPMFPSPVINI 149

  Fly   885 RLTESARIGTVVHCLHATDADSGINAQVTYALSVECSDF---TVNATTG----CLRLNKPLDREK 942
            .:.|:..|.:......|||.|:|.|....|.|....|.|   .|....|    .|.:.:.||||:
Human   150 SIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQ 214

  Fly   943 QDNYALHITAKDGGSPVLSSEALVYVLVDDVNDNAPVFGVQEYIFKVREDLPRGTVLAVIEAVDE 1007
            :|.|.:.|..:|||:|..||.|::.|.|.|||||.|||...:....:.|:.|.||.:..:.|.|.
Human   215 KDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDA 279

  Fly  1008 DIGPNAEIQ--FSLKEETQDEELFRIDKHTGAIRTQGYLDYENKQVHNLIVSAIDGGDPSLTSDM 1070
            |||.||||:  |..:.....:.||.::..||.|..|..||.|...:|.:.|.|.||.  |..:..
Human   280 DIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGS--STPARA 342

  Fly  1071 SIVIMIIDVNENRFAPEFD---------DFVYEGKVKENKPKGTFVMNVTARDMDTVDLNSKITY 1126
            ::.|.:.|||:|  .|..|         ..||   :.|..|..|.:..:|..|.|| |:|.|:..
Human   343 TVTINVTDVNDN--PPNIDLRYIISPINGTVY---LSEKDPVNTKIALITVSDKDT-DVNGKVIC 401

  Fly  1127 SITGGDGLGIFAVND-QGSITSLSQLDAE-TKNFYWLTLCAQDCAIVPLSNCVEVYIQVENENDN 1189
            .|.......:.||.| |..:.:.|.||.| ||.|.: .:.|.|.....|:....|.:::|:||||
Human   402 FIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSF-KIVASDSGKPSLNQTALVRVKLEDENDN 465

  Fly  1190 IPLTDKPVYYVNVTEASVENVEIITLKAFDPDIDPTQTITYNIVSGNLVGYFEIDSKTGVIKTTE 1254
            .|:.::||..::|:|.:...:.:.|:.|.|.|......|.|.:  |....:|::|.||||: |..
Human   466 PPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVL-TAS 527

  Fly  1255 RKLDRENQAEHILEVAISDNGSPVLSSTSRIVVSVLDINDNSPEFDQRVYKVQVPSSATVNQSIF 1319
            |..|||.|...|..|...|||:|.|.|.:.::|:|||.|||||:|....::..|..:.....::.
Human   528 RVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVG 592

  Fly  1320 QVHAIDSDSGENGRITYSIKSGKGKNKFRIDSQRGHI--HIAKPLDSDNEFEIHIKAEDNGIPKK 1382
            .:...|:|:|||..:|.||.:  ..:.|.:|...|.|  :::...:..:.:...:||.|.|.|.:
Human   593 VITVTDADAGENKAVTLSILN--DNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655

  Fly  1383 SQTARVNIVVVPVNPNSQNAPLIV---RKTSENVVDLTENDKPGFLVTQILAVDDD---NDQLWY 1441
            |.||:|.|.|:.||.||   |:::   ..||..:|.|:.  .||.:|.::.|||.|   |.:|.|
Human   656 SSTAKVTINVMDVNDNS---PVVISPPSNTSFKLVPLSA--IPGSVVAEVFAVDVDTGMNAELKY 715

  Fly  1442 NISNGNDDNTFYIGQDNGNILLSKYLDYETQQSYNLTISVTDGTFTAFTNLLVQV-IDINDNPPQ 1505
            .|.:||:...|.|....|||.|.:.........:.|.::::|..:....:.||.| :.:||....
Human   716 TIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780

  Fly  1506 FAKDVY-------HVNISENIEEESVIMQLHATDRDEDKKLFYHLHATQDPSSLALFRIDSISGN 1563
             |..:|       ...:..||.:.|...|      :||               .....|..|:|.
Human   781 -ASYIYDLIRRTMETPLDRNIGDSSQPYQ------NED---------------YLTIMIAIIAGA 823

  Fly  1564 VIVTQRLDFEKTAQHILIVFV-----------------KDQGA-------PGKRNYAKIIVNVHD 1604
            ::|            |:::||                 ..|||       ..|:|..|       
Human   824 MVV------------IVVIFVTVLVRCRHASRFKAAQRSKQGAEWMSPNQENKQNKKK------- 869

  Fly  1605 HNDHHPEFTAKIIQSKVPESAAIGSKLAEVRAIDRDSGHNAEIQYSIITGNVGSVFEIDPTFGII 1669
                      |..:.|.|:|:.:.....|....| |:.|                   :|..|.|
Human   870 ----------KRKKRKSPKSSLLNFVTIEESKPD-DAVH-------------------EPINGTI 904

  Fly  1670 TLAGNLNINKIQEYMLQVKAVDLGNPPLSSQIPVHIIVTMSENDP------------PKF---PT 1719
            :|...|....|..:       |.|..|.:         |...|.|            |.|   |.
Human   905 SLPAELEEQSIGRF-------DWGPAPPT---------TFKPNSPDLAKHYKSASPQPAFHLKPD 953

  Fly  1720 NNIAIE---IFENLPI-GTFV---TQVTARSSSS 1746
            ..::::   :.:.||: .|||   ..::.|||:|
Human   954 TPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTS 987

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637 25/108 (23%)
Cadherin_repeat 883..976 CDD:206637 34/99 (34%)
Cadherin_repeat 984..1082 CDD:206637 33/99 (33%)
Cadherin_repeat 1092..1189 CDD:206637 31/98 (32%)
Cadherin_repeat 1197..1295 CDD:206637 35/97 (36%)
Cadherin_repeat 1303..1386 CDD:206637 19/84 (23%)
Cadherin_repeat 1413..1502 CDD:206637 27/92 (29%)
Cadherin_repeat 1510..1608 CDD:206637 20/128 (16%)
Cadherin_repeat 1621..1713 CDD:206637 16/91 (18%)
Cadherin_repeat 1724..1811 CDD:206637 9/30 (30%)
Cadherin_repeat 1819..1927 CDD:206637
Cadherin_repeat 1948..2030 CDD:206637
Cadherin_repeat 2037..2136 CDD:206637
Cadherin_repeat 2144..2235 CDD:206637
Cadherin_repeat 2246..2336 CDD:206637
Cadherin_repeat 2345..2445 CDD:206637
Cadherin_repeat 2453..2545 CDD:206637
Cadherin_repeat 2555..>2633 CDD:206637
Cadherin_repeat 2658..2759 CDD:206637
Cadherin_repeat 2774..2856 CDD:206637
Cadherin_repeat 2865..2963 CDD:206637
Cadherin_repeat 2974..3063 CDD:206637
Cadherin_repeat 3072..3165 CDD:206637
Cadherin_repeat 3173..3269 CDD:206637
Cadherin_repeat 3277..3374 CDD:206637
Cadherin_repeat 3383..3479 CDD:206637
Cadherin_repeat 3488..3579 CDD:206637
Cadherin_repeat 3590..3681 CDD:206637
EGF_CA 3866..3903 CDD:238011
Laminin_G_2 3953..4077 CDD:460494
EGF_CA <4121..4150 CDD:238011
EGF_CA 4152..4189 CDD:238011
EGF_CA 4195..4225 CDD:238011
EGF_CA 4227..4262 CDD:214542
PCDH9NP_982354.1 Cadherin_repeat 29..138 CDD:206637 29/117 (25%)
Cadherin_repeat 146..248 CDD:206637 34/101 (34%)
Cadherin_repeat 258..354 CDD:206637 33/97 (34%)
Cadherin_repeat 370..465 CDD:206637 31/99 (31%)
Cadherin_repeat 473..568 CDD:206637 35/97 (36%)
Cadherin_repeat 576..671 CDD:206637 26/96 (27%)
Cadherin_repeat 687..776 CDD:206637 26/90 (29%)
Protocadherin 777..1000 CDD:462451 53/298 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 849..882 10/49 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 984..1035 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1055..1084
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1122
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1186..1237
Blue background indicates that the domain is not in the aligned region.

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