DRSC/TRiP Functional Genomics Resources

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Protein Alignment kug and PCDH7

DIOPT Version :10

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:NP_001166994.1 Gene:PCDH7 / 5099 HGNCID:8659 Length:1255 Species:Homo sapiens


Alignment Length:1171 Identity:284/1171 - (24%)
Similarity:453/1171 - (38%) Gaps:290/1171 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  2592 SEEMKKIFLIDQTTGVI-TSKVTFDREK---------KDEYVVLLKVSDGGGKFGFASL---KVI 2643
            ||.:|    ||..||.: ||:...||||         ::|..:..:||..|....:..|   :||
Human    72 SEYLK----IDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVI 132

  Fly  2644 VVDVNDNVPYFLLKEYKMVVSTTVEANQTILTV----KAKDDDIVDNGSVHFQIVQKSNDKAVKD 2704
            |:|:|||.|.|    ...|::.|||.|:.:.|:    .|.|.|...||...::::|:...     
Human   133 VLDINDNTPTF----PSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGG----- 188

  Fly  2705 VIEINEKTGDIVFKSKAESY-----GVNSYQFFVRASDRGEPQFHSEVPVSIEIIETDANIPTFE 2764
                ....|:......|:|.     |.|.      ||..|.......:..|    |.........
Human   189 ----GGSGGESRRAGAADSAPYPGGGGNG------ASGGGSGGSKRRLDAS----EGGGGTNPGG 239

  Fly  2765 KSSVLLKIIESTPPGTVLTKLHMIGNYTFKFSIAADQDHFMISDSGELILQQTLDREQQESHNLI 2829
            :|||....:..||.|                           ....:||::..|||||::|:.|.
Human   240 RSSVFELQVADTPDG---------------------------EKQPQLIVKGALDREQRDSYELT 277

  Fly  2830 VVAETSTVPVFFAYADVLIDVRDENDNYPKFDNTFYSASVAENSEKVISLVKVSATDADTGPNGD 2894
            :.......|...:.|.:.:.:.|.|||.|:|:.:.|.|.:||||.....::::.|.|.|.|.||.
Human   278 LRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQ 342

  Fly  2895 IRYYLESDTENIQNIFDIDIYSGWITLLTSLDREVQSEYNFKVIAADNGHPKHDAKVPVTIKIVD 2959
            |.|...:.||:::.:..:|..|||:::|..:|||..::..|.|:|.|.|.|....|..|.:.|.|
Human   343 IEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKD 407

  Fly  2960 YNDNAP------VFKLPI-EGL-SVFENALPGTVLINLLLIDPDIEKQEMDFFIVSGDKQAQFQI 3016
            .|||.|      :.::|: :|: :|.|:          :|:|..|               |..|:
Human   408 ENDNVPSIEIRKIGRIPLKDGVANVAED----------VLVDTPI---------------ALVQV 447

  Fly  3017 GKSGELFIAKPLDREQLMFYNLSIIATDGKFTAKANVEIDVKDINDNTPYCLKPRYHISTNESIS 3081
            .           ||:|         ..:|..|...     |.|:    |:.|||           
Human   448 S-----------DRDQ---------GENGVVTCTV-----VGDV----PFQLKP----------- 472

  Fly  3082 IGTTLVEVKAIDFD-FQSKLRFYLSGKGADDFSIGKESGILKVASALDRETTPKYKLVAHVQDGK 3145
                     |.|.: .|:|.:::                 |..::.||.|.|.::.:|....|..
Human   473 ---------ASDTEGDQNKKKYF-----------------LHTSTPLDYEATREFNVVIVAVDSG 511

  Fly  3146 DFTQECFSEIIITVNDINDNMPIFSMAQYRVSVPEDAQLNTLITKVHAMDKDFGVNRQIKYSLMG 3210
            ..:....:.:|:.|.|.|||.|:|..:...|..||:......:..|.|.|.|.|.|.:|.|||..
Human   512 SPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDS 576

  Fly  3211 ENHDYFKISKSTGIIRLHKSLDRETISLFNLTVKAEDCGVPKLHSIATVAVNILDINDNPPEFSM 3275
            .....|.|...:|.|.::..||||....:...|.|:|.|:|.|....||.|.:.|.|||.|:|..
Human   577 SVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQ 641

  Fly  3276 RQYSCKILENATHGTEVCKVYATSIDIGVNADIHYFIMSGNEQGKFKMDSTTGDLVLNATLDYEM 3340
            ..::..:.||....:.|..|.....|.|.||::..:|...|  ..|.:::.||.:....:.|.|.
Human   642 DVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENN--NIFSIENDTGTIYSTMSFDREH 704

  Fly  3341 SKFYFLTIQAIDGGTPPLSNNAYVNISILDINDNSPTFL--QNLYRINVNEDIFVGSKILDVKAT 3403
            ...|...::|:|||.||.|..|.|::.::|.|||:||..  :|:....:.....|.:.:..|.||
Human   705 QTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLAT 769

  Fly  3404 DEDSDVNGLVTYNIERGDNIGQFSIDPKNGTISVSRPLDRETISHYTLEIQACDQGDPQRCNSVP 3468
            |.|..:|..:.|:|..|:....|.|||.:|.:|:...|.::....:.|.:|..|.|.|.:..:..
Human   770 DSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTL 834

  Fly  3469 ININILDTNDNAPIFSSSNYSVVLQENRLLGYVFLTFKISDADETPNTTPYTFDI---------- 3523
            :::.:.::..||....|       |..|.| ::.||..|: .|.:...:.....|          
Human   835 VHVFVNESVSNATAIDS-------QIARSL-HIPLTQDIA-GDPSYEISKQRLSIVIGVVAGIMT 890

  Fly  3524 --------------RSGNEGGLFRLEQD------------------------------GSLRTAS 3544
                          ||.|:.|....::|                              .|:.|..
Human   891 VILIILIVVMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVE 955

  Fly  3545 RFNHNLQDEFVIQVRVFDN-------------GTPPL-----YSDAWVVVKIIEES--------- 3582
            ....|.|....:..::.|:             |:|.|     .|.....|::..:|         
Human   956 ASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQA 1020

  Fly  3583 --QYPPIVTPLEVTINSFEDDFSGAFIGKVHASD-----QDKYDE-----LNFSLVSGPDDMYQS 3635
              ..||        .|:|........||..|.|:     .:||.:     :.||:||.|.|.:|.
Human  1021 VQDLPP--------ANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQPFRRVTFSVVSQPQDPHQG 1077

  Fly  3636 S 3636
            |
Human  1078 S 1078

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637
Cadherin_repeat 883..976 CDD:206637
Cadherin_repeat 984..1082 CDD:206637
Cadherin_repeat 1092..1189 CDD:206637
Cadherin_repeat 1197..1295 CDD:206637
Cadherin_repeat 1303..1386 CDD:206637
Cadherin_repeat 1413..1502 CDD:206637
Cadherin_repeat 1510..1608 CDD:206637
Cadherin_repeat 1621..1713 CDD:206637
Cadherin_repeat 1724..1811 CDD:206637
Cadherin_repeat 1819..1927 CDD:206637
Cadherin_repeat 1948..2030 CDD:206637
Cadherin_repeat 2037..2136 CDD:206637
Cadherin_repeat 2144..2235 CDD:206637
Cadherin_repeat 2246..2336 CDD:206637
Cadherin_repeat 2345..2445 CDD:206637
Cadherin_repeat 2453..2545 CDD:206637
Cadherin_repeat 2555..>2633 CDD:206637 16/50 (32%)
Cadherin_repeat 2658..2759 CDD:206637 22/109 (20%)
Cadherin_repeat 2774..2856 CDD:206637 16/81 (20%)
Cadherin_repeat 2865..2963 CDD:206637 35/97 (36%)
Cadherin_repeat 2974..3063 CDD:206637 14/89 (16%)
Cadherin_repeat 3072..3165 CDD:206637 15/93 (16%)
Cadherin_repeat 3173..3269 CDD:206637 32/95 (34%)
Cadherin_repeat 3277..3374 CDD:206637 27/96 (28%)
Cadherin_repeat 3383..3479 CDD:206637 22/95 (23%)
Cadherin_repeat 3488..3579 CDD:206637 23/162 (14%)
Cadherin_repeat 3590..3681 CDD:206637 16/57 (28%)
EGF_CA 3866..3903 CDD:238011
Laminin_G_2 3953..4077 CDD:460494
EGF_CA <4121..4150 CDD:238011
EGF_CA 4152..4189 CDD:238011
EGF_CA 4195..4225 CDD:238011
EGF_CA 4227..4262 CDD:214542
PCDH7NP_001166994.1 Cadherin_repeat 35..139 CDD:206637 23/70 (33%)
Cadherin_repeat 147..304 CDD:206637 41/202 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..242 11/78 (14%)
Cadherin_repeat 312..411 CDD:206637 35/98 (36%)
Cadherin_repeat 429..531 CDD:206637 33/192 (17%)
Cadherin_repeat 541..635 CDD:206637 32/93 (34%)
Cadherin_repeat 643..738 CDD:206637 27/96 (28%)
Cadherin_repeat 749..839 CDD:206637 22/89 (25%)
Protocadherin 842..1053 CDD:462451 35/227 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 910..988 7/77 (9%)
Blue background indicates that the domain is not in the aligned region.

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