DRSC/TRiP Functional Genomics Resources

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Protein Alignment kug and pcdh2ab7

DIOPT Version :10

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:NP_001009594.1 Gene:pcdh2ab7 / 493593 ZFINID:ZDB-GENE-041118-6 Length:939 Species:Danio rerio


Alignment Length:706 Identity:222/706 - (31%)
Similarity:317/706 - (44%) Gaps:104/706 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   780 SINESVQLGETVAWIEAKD-----RDLGYNGKLVFAISDGDYDSVFRIDPDRGELQIIGYLDRER 839
            |::|.|..|.||..| .|:     ::|.:.|   |.|. |.....|.::...|.||:...||||.
Zfish    32 SVSEEVSPGTTVGNI-VKELNLNLQELEHRG---FQIV-GPNKRYFDVNMKTGILQVKDKLDREE 91

  Fly   840 ----------QNEYVLN--ITVYDLGNPTKSTSKMLPITILDVNDNRPVIQKTLATFRLTESARI 892
                      :.|.::|  :.:|           ...:.:||:|||.|....:.....::|:|.|
Zfish    92 ICGQSLKCALELEAIVNSPLNMY-----------RFEVNVLDINDNSPTFHSSSLQLNVSEAAFI 145

  Fly   893 GTVVHCLHATDADSGINAQVTYALSVECSDFTVNATTGC-------LRLNKPLDREKQDNYALHI 950
            |.......|.|||.|||:..:|.||.. ..|:::..:|.       |.|.|.||||||....|.:
Zfish   146 GERYSLPSADDADVGINSVKSYKLSAN-EHFSLDVQSGGEQSVSAELVLQKALDREKQPVIRLTL 209

  Fly   951 TAKDGGSPVLSSEALVYVLVDDVNDNAPVFGVQEYIFKVREDLPRGTVLAVIEAVDEDIGPNAEI 1015
            ||.|||.|..|....:.|.:.|.|||.|||....|..::.|:.|.||.:..:.|.|.|.|.|.||
Zfish   210 TAVDGGKPARSGTVNIIVKIIDANDNIPVFTKSLYKARIPENAPVGTSIITVNARDADEGLNGEI 274

  Fly  1016 QFSLKEETQDE--ELFRIDKHTGAIRTQGYLDYENKQVHNLIVSAIDGGDPSLTSDMSIVIMIID 1078
            ::|..:...|.  |.|.|::.:|.|...|.||:|:.....:.|.|.|.|.....:...::|.|:|
Zfish   275 EYSFIKHKNDRIIESFAINEVSGEITVLGKLDHESNNAVEIRVQARDKGSLPRAAHCKVLIEIMD 339

  Fly  1079 VNENRFAPEFDDFVYEGKVKENKPKGTFVMNVTARDMDTVDLNSKITYSITGGDGLGIFAVNDQG 1143
            ||:|  .||.........|.|:.||||.|..||.:|.|:.: |..:...|.  |.|.....|...
Zfish   340 VNDN--IPEISVTSLVNVVNEDSPKGTMVGLVTVKDDDSGE-NGSVKLKIL--DSLPFALQNTYK 399

  Fly  1144 SITSL---SQLDAETKNFYWLTLCAQDCAIVPLSNCVEVYIQVENENDNIPLTDKPVYYVNVTEA 1205
            :..||   ..||.|..:.|.:|:.|.|....|||:...:.:.|.:.|||.|...:||..|.|.|.
Zfish   400 NKYSLVVDGPLDRERASEYNVTISAADEGSPPLSSTSVIAVHVSDVNDNAPRFPEPVINVYVKEN 464

  Fly  1206 SVENVEIITLKAFDPDIDPTQTITYNIV----SGNLVGYFEIDSKTG-----------VIKTTER 1255
            |.....:.|:.|.|||:.....|||:::    ||.:.....|:|.||           .|||.|.
Zfish   465 SQIGAVLHTVSAVDPDVGDNARITYSLLESSKSGPVTSMININSDTGDLHSLQSFNYEEIKTFEF 529

  Fly  1256 KLDRENQAEHILEVAISDNGSPVLSSTSRIVVSVLDINDNSP----EFDQ--RVYKVQVPSSATV 1314
            |            |..:|:|.|.|||...:.|.|||.|||||    .:.:  .|....:|.||..
Zfish   530 K------------VQATDSGVPPLSSNVTVNVFVLDENDNSPAILAPYSELGSVNTENIPYSAEA 582

  Fly  1315 NQSIFQVHAIDSDSGENGRITYSIKSGKGKNKFRIDSQRGHIHIAKPLDSDNEFEIH---IKAED 1376
            ...:.::.|:|:|||.|..::|.|...||.|.|||.:..|.|...:.: |||:.:.|   |...|
Zfish   583 GYFVAKIRAVDADSGYNALLSYHISEPKGNNLFRIGTSSGEIRTKRRM-SDNDLKTHPLVILVCD 646

  Fly  1377 NGIPKKSQTARVNIVVV-------------PVNPNS---QNAPLIVRKTSENVVDL 1416
            ||.|..|.|..::.|||             ||...|   .|..|::...|.:|:.|
Zfish   647 NGEPSLSATVSIDAVVVESGGDVKTPFRHAPVKEESFSDLNLYLLIAIVSVSVIFL 702

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637 27/109 (25%)
Cadherin_repeat 883..976 CDD:206637 36/99 (36%)
Cadherin_repeat 984..1082 CDD:206637 32/99 (32%)
Cadherin_repeat 1092..1189 CDD:206637 30/99 (30%)
Cadherin_repeat 1197..1295 CDD:206637 36/112 (32%)
Cadherin_repeat 1303..1386 CDD:206637 30/85 (35%)
Cadherin_repeat 1413..1502 CDD:206637 2/4 (50%)
Cadherin_repeat 1510..1608 CDD:206637
Cadherin_repeat 1621..1713 CDD:206637
Cadherin_repeat 1724..1811 CDD:206637
Cadherin_repeat 1819..1927 CDD:206637
Cadherin_repeat 1948..2030 CDD:206637
Cadherin_repeat 2037..2136 CDD:206637
Cadherin_repeat 2144..2235 CDD:206637
Cadherin_repeat 2246..2336 CDD:206637
Cadherin_repeat 2345..2445 CDD:206637
Cadherin_repeat 2453..2545 CDD:206637
Cadherin_repeat 2555..>2633 CDD:206637
Cadherin_repeat 2658..2759 CDD:206637
Cadherin_repeat 2774..2856 CDD:206637
Cadherin_repeat 2865..2963 CDD:206637
Cadherin_repeat 2974..3063 CDD:206637
Cadherin_repeat 3072..3165 CDD:206637
Cadherin_repeat 3173..3269 CDD:206637
Cadherin_repeat 3277..3374 CDD:206637
Cadherin_repeat 3383..3479 CDD:206637
Cadherin_repeat 3488..3579 CDD:206637
Cadherin_repeat 3590..3681 CDD:206637
EGF_CA 3866..3903 CDD:238011
Laminin_G_2 3953..4077 CDD:460494
EGF_CA <4121..4150 CDD:238011
EGF_CA 4152..4189 CDD:238011
EGF_CA 4195..4225 CDD:238011
EGF_CA 4227..4262 CDD:214542
pcdh2ab7NP_001009594.1 Cadherin_2 28..108 CDD:462413 22/80 (28%)
Cadherin_repeat 134..235 CDD:206637 36/101 (36%)
Cadherin_repeat 244..343 CDD:206637 32/98 (33%)
Cadherin_repeat 356..448 CDD:206637 30/94 (32%)
Cadherin_repeat 456..557 CDD:206637 36/112 (32%)
Cadherin_repeat 575..658 CDD:206637 30/83 (36%)
Cadherin_C_2 685..757 CDD:465139 5/18 (28%)
Cadherin_tail 794..911 CDD:435046
Blue background indicates that the domain is not in the aligned region.

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