DRSC/TRiP Functional Genomics Resources

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Protein Alignment kug and Cad74A

DIOPT Version :9

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster


Alignment Length:2217 Identity:500/2217 - (22%)
Similarity:841/2217 - (37%) Gaps:658/2217 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   881 LATFRLTESARIGTVVHCLHATDADSGINAQVTYALSVECSDFTVNATTGCLRLNKPLDREKQDN 945
            ::.|.|:|:..:|:.|..|..||.:.|   ::.|::|...  |:|:..||.:||.:.||||.||.
  Fly    31 MSRFSLSENTPVGSPVFQLKGTDPEGG---RLKYSISGPV--FSVDRETGVVRLRQELDRETQDT 90

  Fly   946 YALHITAKD----GGSPVLSSEALVYVLVDDVNDNAPVFGVQEYIFKVREDLPRGTVLAV---IE 1003
            ..:.|:..|    |..|...|:..| :.|.|.|||.|.|..:.|...|.|.||.|:.|:|   |.
  Fly    91 VEVIISITDEGIYGTEPNTVSQRRV-IPVRDYNDNQPTFLGRPYTASVSESLPVGSELSVEPPIV 154

  Fly  1004 AVDEDIGPNAEIQFSLKEETQDEELFRI-------DKHTGAIRTQGYLDYENKQVHNLIVSAIDG 1061
            .||.|.|.|:|:|....||....::|.:       ..:|..:..:..||:|::..:.|.:||.|.
  Fly   155 VVDRDEGINSEVQMKCLEENDICDIFEVRAVKISDGNYTARVALKQQLDFESRPSYILTISASDS 219

  Fly  1062 G-DPSLTSDMSIVIMIIDVNENRFAPEFDDFVYEGKVKENKPKGTFVMNVTARDMDTVDLNSKIT 1125
            . |..|:|..:|.|.:||:.:.  .|.|.:..|...|.||.|.|..::.|.|.|.|         
  Fly   220 ALDNRLSSLATISINVIDIQDQ--PPIFTNAPYSATVPENTPAGVSILTVKAVDGD--------- 273

  Fly  1126 YSITGGDGLGIFAVNDQGSITSLSQLDAETKNFYWLTLCAQDCAIVPLSNCVEVYIQVENENDNI 1190
                    :||                                   |.    |:::.:|      
  Fly   274 --------VGI-----------------------------------PR----EIFLSLE------ 285

  Fly  1191 PLTDKPVYYVNVTEASVENVEIITLKAFDPDIDPTQTITYNIVSGNLVGYFEI----DSK--TGV 1249
               |:|                                         .|:||:    |.:  |.|
  Fly   286 ---DEP-----------------------------------------FGHFELVPFGDPRDGTAV 306

  Fly  1250 IKTTERKLDRENQAE----------HILEVAISDNGSPVLSSTSRIVVSVLDINDNSPEFDQRVY 1304
            ::||...||||| ||          .|....:.|...|...|.:|:.:.|.|::|:.|.|....:
  Fly   307 LQTTSEPLDREN-AEILQNGGVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQPTFSGPHF 370

  Fly  1305 KVQVPSSATVNQSI--FQVHAIDSDSGENGRITYSIKSGKGKNKFRIDSQRGHIHIAKPLDSDNE 1367
            .|.:..:......:  ..:...|.|.|||.|...|::.                    ..::...
  Fly   371 NVSITENLANGMPLPGLSIFVDDRDMGENSRYELSLRD--------------------VFNAARV 415

  Fly  1368 FEIHIKAEDNGIPKKSQTARVNIVVVPVNPNSQNAPLIVRKTSENVVDLTENDKPGFLVTQILAV 1432
            ||:.        |.:||               ...|::|:..:.:.:|..             .|
  Fly   416 FEVS--------PTESQ---------------GRTPVVVKVLNASRLDYD-------------VV 444

  Fly  1433 DDDNDQLWYNISNGNDDNTFYIGQDNGNILLSKYLDYETQQSYNLTISVTDGTFTAFTNLLVQVI 1497
            |.|                           |.|:       .::|..|| .|...|.|.:.:.::
  Fly   445 DPD---------------------------LRKF-------EFDLVASV-KGVEKAKTRVEIHLL 474

  Fly  1498 DINDNPPQFAKDVYHVNISENIEEESVIMQLHATDRDEDKKLFYHLHATQDPSSLALFRIDSISG 1562
            |.|||.|.|.:..|....:||:..:::|..:.|||.|..:  |.|:...........|.::..:|
  Fly   475 DANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGE--FGHVRYVLKGFGADNFYVNPETG 537

  Fly  1563 NVIVTQRLDFEKTAQHILIVFVKDQGAPGKRNYAKIIVNVHDHNDHHPEFTAKIIQSKVPESAAI 1627
            .|.:.:.||:||.:.:.|.|...|.|.  :...|.:.|.|.|.||:||.|.:|.....:.|.||:
  Fly   538 GVYLLKPLDYEKQSSYSLTVVAIDGGQ--REANANLFVGVTDVNDNHPNFESKEYSRTIREGAAL 600

  Fly  1628 GSKLAEVRAIDRD--SGHNAEIQYSIITGN--VGSVFEIDPTFGIITL---AGNLNINKIQEYML 1685
            ......|||.|.|  |..|..::|||::.|  .|:||.|:|..|.|.:   |.:::..: .||.|
  Fly   601 FEPQFFVRAHDADGPSQGNGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTER-GEYEL 664

  Fly  1686 QVKAVDLGNPPLSSQIPVHIIVTMSENDPPKF---------------PTNNIAIEIFENLPIGTF 1735
            .|.|.|.|.||||:...|.:.|.:|.|..|.|               |:..::|.  ||...|:.
  Fly   665 VVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIP--ENAAAGSN 727

  Fly  1736 VTQVTARS----SSSIFFNIISGNINESFRINPSTGVIVIN--GNIDYES-IKVFNLTVKGTNMA 1793
            ||.|:|..    .|.:.:.|:..  |::|.|:..:|:|.::  ..||.:| :..|.:.|...:..
  Fly   728 VTSVSAHDPDGLDSLLRYRIVGA--NDNFEIDEISGLITVSPQARIDRDSNMNSFEIIVNAVDSG 790

  Fly  1794 A---ESSCQNIIIHILDANDNIPYFVQNEYVGALPESAAIGSYVLKVHDSSKDHLTLQVKDADVG 1855
            .   |::...:.:::.|.||..|.|.||.|...:.|..|:|..||:|....||            
  Fly   791 TPIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKD------------ 843

  Fly  1856 VNGMVEYHIVDDLA------------KNF-----FKIDSTTGAIELLRQLDYETNAGYTFDVTVS 1903
            :|..:||.:|..:|            .|:     |::||.:|.|.:...|.::..|...|.|.|.
  Fly   844 LNSKLEYSMVGPVAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVR 908

  Fly  1904 DMG---KPKLHSTTTAHVTIRVINVNDCPPVFNER---------ELNVTLFLPTFENVFVRQVSA 1956
            |:.   .|:....|| .||:.|.:..|..|||...         ::.:...:|....:|:.|...
  Fly   909 DLNAEVDPEGQVDTT-EVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAED 972

  Fly  1957 KDADNDTLRFDIVDGNTNECFQIEKYTGIITTR---NFEILNNENDRDYALHVRA--SDGIFSAI 2016
            .........|::::....:.||:.:.||.:..:   ::|.| .:...::.|.|||  :|...|.:
  Fly   973 PVTRQPITSFELIEPKQVDYFQVAERTGEVILKKRLDYEAL-GDTGPEFELQVRANSADRQRSTV 1036

  Fly  2017 LIVKIKVLSAIDSNFAFQRESYRFSAFENNTKVATIGLVNVIG-----NTLDENVEY-RILNPTQ 2075
            ..|.|.|.:..|::..|:|.||:.:..||......:..|..:.     |..||.:.| :|:...|
  Fly  1037 SRVNITVENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQ 1101

  Fly  2076 -----LFDIGISSG-ALKTTGVIFDREVKDLYRLFVEAKSMLYDGMNSNVRRAVTSIDISVLDVN 2134
                 ||||..::| .:..:|...|||.....:|.::|:..  .|..::.:::|..:.|.|||||
  Fly  1102 GEHAMLFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDS--PGRPTDAKQSVVELQIEVLDVN 1164

  Fly  2135 DNCPLFVNMPYYATVSIDDPKGTIIMQVKAIDLDSAENGEVRYEL---KKGNGELFKLDRKSGEL 2196
            ||.|.|....|...:..:....:.::|::|:|.|....|||||||   .:.|| |||:|.|||.:
  Fly  1165 DNAPEFTQKKYSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANG-LFKIDTKSGLI 1228

  Fly  2197 SIKQHVEGHNR--NYELTVAAYDGAITPCSSEAPLQVKVIDRSMPVFEKQFYTVSVKEDVEMYSA 2259
            |.::::.|..|  .|.|.|.|.|.     .::.|.|.               |:|...||.:|  
  Fly  1229 STRRNLTGKGRAHPYVLIVRAQDN-----GNQMPKQP---------------TLSTDTDVRIY-- 1271

  Fly  2260 LSVSIEAESPLGRSLIYTISSESQSFEIDYNTGSIFVVNELDYEKISSHDVSIRATDSLSGVYAE 2324
                      :|                                     |||             
  Fly  1272 ----------IG-------------------------------------DVS------------- 1276

  Fly  2325 VVLSVSIMDVNDCYPEIES----DIYNLTIPENASFGTQILKINATDND--SGANAKLSYYIESI 2383
                     .||..|...|    .:.|:|  |||..|..:.::.|:|.|  |..:..::|.|  :
  Fly  1277 ---------ANDGVPYFLSPRVGQMANVT--ENAVTGAPVFQVIASDPDDESTPSGTITYRI--L 1328

  Fly  2384 NGQNNSELFYIDVTDGNLYLKTPLDYEQIKYHHIVVNVKDHGSPSLSSRSNVFITVKDLNDNAPC 2448
            ....::|.|.||...|.:..:..:|.|....:.|::.|.|:|.|..|:...:.|.:.|::|:.|.
  Fly  1329 PDTPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQPKQSATRILQIAILDVDDHEPR 1393

  Fly  2449 FVEPSYFTKVSVA--------AVRGQFVALPKAYDKDISDTDSLEYKIVYGNELQTYSIDKLTGV 2505
            |...:....:|::        .:.|.|.||    |:|:.:..:::|.|:.||..|.::|::    
  Fly  1394 FAREADAGPLSMSVREEEPAGTIVGNFSAL----DEDLGENAAIDYVIIDGNNEQLFTIER---- 1450

  Fly  2506 ISLQNMLNFTDKSSTVLNISVSDGVHTAYARLKISLLPENVYSPLFDQSTYEAQVPENLLHGHNI 2570
                                                                             
  Fly  1451 ----------------------------------------------------------------- 1450

  Fly  2571 ITVKASDGDFGTYANLYYEIVSEEMKKIFLIDQTTGVITSKVTFDREKKDEY---VVLLKVSDGG 2632
                                          .:::..::.:|...|||:.:.:   :..||:.:.|
  Fly  1451 ------------------------------NNESLAILKTKKPIDREQVESFTLTIKCLKLGEPG 1485

  Fly  2633 GKF----------GFASLKVIVVDVNDNVPYFLLKEYKMVVSTTVEANQTILTVKAKDDDI---- 2683
            .||          ....:.|.|:|::||:|.|...:..:.:...|..:..:.|:||.|.|.    
  Fly  1486 YKFIGDPYDRQDLSHLRINVRVLDIDDNLPKFEQPDPTVGIRINVPIDTVVTTLKASDADAEAPP 1550

  Fly  2684 ----VDNGSVHFQIVQKSNDKAV---KDVIEINEKTGDIVFKSKAESYGVNSYQFFVR--ASDRG 2739
                ::|.:...|..::|...||   .::..:|.:||::........| |:.| |.:|  |::..
  Fly  1551 VGLSIENVTFVPQFYKRSRSLAVGNLHNLFTLNNRTGELRTGGSFADY-VDGY-FLMRVMANNSV 1613

  Fly  2740 EP--QFHSEVPVSIEIIETDANIPTFEKSSVLLKIIESTPPGTVLTKLHMIGNYTFKFSIAADQD 2802
            :|  |.||.:.|.:          ..:||  |||.:.:.||..:            :.:|...|:
  Fly  1614 QPKRQAHSNLKVFV----------IRDKS--LLKFVFARPPNEI------------QHNIRPFQE 1654

  Fly  2803 HFMISDSGELILQQTLDREQQESHNLIVVAETSTVPVFFAYADVLIDVRDENDNYPKFDN----T 2863
            .          ||:.|.....|.|    |.:|..    |...|:.:|....:..:..|.|    :
  Fly  1655 Q----------LQKKLKPLGLELH----VLDTQV----FTRPDMSLDFTATSSCFQMFKNGAALS 1701

  Fly  2864 FYSASVAENSEKV-ISLVKVSATDADTGPNGDIRYYLESDTE--NIQNIFDIDIYSG-------W 2918
            |.......||::: ..|:.:.|.            |..|:.|  :::......|::|       |
  Fly  1702 FNEMQKLMNSQQLRQELIDIYAA------------YGVSEVESCSVRRTHAAAIFAGMLTSAGAW 1754

  Fly  2919 ITLLTSL 2925
            :..|.:|
  Fly  1755 LVFLAAL 1761

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
E_set 309..390 CDD:298831
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637
Cadherin_repeat 883..976 CDD:206637 32/96 (33%)
Cadherin_repeat 984..1082 CDD:206637 34/108 (31%)
Cadherin_repeat 1092..1189 CDD:206637 15/96 (16%)
Cadherin_repeat 1197..1295 CDD:206637 22/113 (19%)
Cadherin_repeat 1303..1386 CDD:206637 13/84 (15%)
Cadherin_repeat 1413..1502 CDD:206637 14/88 (16%)
Cadherin_repeat 1510..1608 CDD:206637 26/97 (27%)
Cadherin_repeat 1621..1713 CDD:206637 36/98 (37%)
Cadherin_repeat 1724..1811 CDD:206637 23/96 (24%)
Cadherin_repeat 1819..1927 CDD:206637 32/127 (25%)
Cadherin_repeat 1948..2030 CDD:206637 19/86 (22%)
Cadherin_repeat 2037..2136 CDD:206637 30/110 (27%)
Cadherin_repeat 2144..2235 CDD:206637 31/95 (33%)
Cadherin_repeat 2246..2336 CDD:206637 9/89 (10%)
Cadherin_repeat 2345..2445 CDD:206637 27/101 (27%)
Cadherin_repeat 2453..2545 CDD:206637 13/99 (13%)
Cadherin_repeat 2555..>2633 CDD:206637 6/80 (8%)
Cadherin_repeat 2658..2759 CDD:206637 25/115 (22%)
Cadherin_repeat 2774..2856 CDD:206637 14/81 (17%)
Cadherin_repeat 2865..2963 CDD:206637 12/71 (17%)
Cadherin_repeat 2974..3063 CDD:206637
Cadherin_repeat 3072..3165 CDD:206637
Cadherin_repeat 3173..3269 CDD:206637
Cadherin_repeat 3277..3374 CDD:206637
Cadherin_repeat 3383..3479 CDD:206637
Cadherin_repeat 3488..3579 CDD:206637
Cadherin_repeat 3590..3681 CDD:206637
EGF_CA 3866..3903 CDD:238011
Laminin_G_2 3953..4077 CDD:280389
EGF_CA <4121..4150 CDD:238011
EGF_CA 4152..4189 CDD:238011
EGF_CA 4195..4225 CDD:238011
EGF_CA 4227..4262 CDD:214542
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637 32/96 (33%)
Cadherin_repeat 132..240 CDD:206637 34/107 (32%)
Cadherin_repeat 249..361 CDD:206637 39/218 (18%)
Cadherin_repeat 369..479 CDD:206637 29/200 (15%)
Cadherin_repeat 487..581 CDD:206637 26/97 (27%)
Cadherin_repeat 589..686 CDD:206637 34/97 (35%)
Cadherin_repeat 713..810 CDD:206637 22/100 (22%)
Cadherin_repeat 819..936 CDD:206637 33/129 (26%)
Cadherin_repeat 953..1049 CDD:206637 19/96 (20%)
Cadherin_repeat 1057..1166 CDD:206637 30/110 (27%)
Cadherin_repeat 1175..1279 CDD:206637 40/195 (21%)
Cadherin_repeat 1293..1390 CDD:206637 27/100 (27%)
Cadherin_repeat 1402..1513 CDD:206637 25/213 (12%)
Cadherin_repeat 1523..1628 CDD:206637 25/116 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24026
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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