DRSC/TRiP Functional Genomics Resources

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Protein Alignment kug and CDHR4

DIOPT Version :9

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:XP_016861855.1 Gene:CDHR4 / 389118 HGNCID:34527 Length:841 Species:Homo sapiens


Alignment Length:672 Identity:155/672 - (23%)
Similarity:265/672 - (39%) Gaps:119/672 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   611 PQFERVNCYGKVTKSAP------MGT---EVFVTSAIDFDAGDIISYRL----SDGNE--DGCFN 660
            |..|.:|.....|...|      .||   ::.::|:...||..:..|::    :.||.  :|..:
Human   103 PTLELLNVQPPTTFFNPPSLARWQGTYVGKLTLSSSAQLDALMVNHYKVQLKFTCGNHVMEGSLS 167

  Fly   661 LDPTSGSLSISCDLKKTTLTNRILKV--SATDGTHFSDDLIINVHLMPEDLGGDSSIL------H 717
            :|.......|.|..:..:....:::|  :.|.|......|:..:.|.    |...||:      |
Human   168 VDVQRDLSHIQCAGQFASPAGEMIQVPETVTPGARLYTLLLPGLELH----GAQMSIISAQDLPH 228

  Fly   718 GFGSFECRETGVARRLAETLSLAEKNNV------------KSASPSVFSDLSLTPSRYGQNVHRP 770
            ..|.|...|.|..:..::.| |.:...|            :|....|...:...||      .:.
Human   229 FPGPFSINEQGWLQAPSQGL-LGQAQKVFQLQISVSFGQRQSCQGMVIVKVLPVPS------SQV 286

  Fly   771 EFVNFPQELSINESVQLGETVAWIEAKDRDLGYNGKLVFAISDGDYDSVFRIDPDRGELQIIGYL 835
            .|:...|.::|.|::..|..|..::|:..||.|.   :.:.......|:.|.|   |.::....|
Human   287 SFLEQAQNITIPENLAPGSEVVQVQARGVDLRYE---ILSPVPSPLFSIGRAD---GVVRTTTPL 345

  Fly   836 DRERQNEYV---LNITVYDLGNPTKSTSKMLPITILDVNDNRPVIQKTLATFRLTESARIGTVVH 897
            :..|.:...   |.:..::.|....|....|.:.:..||...|.....|...::.|:|.:|||::
Human   346 ELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLWPPRCLPALLVSQIPETAPVGTVLN 410

  Fly   898 CLHATDADSGINAQVTYALSVECSDFTVNATTGC-----LRLNKPLDREKQD---NYALHITAKD 954
            .|...|.|| :.|.:.|.|....|.   |..:.|     |.:|..||.:...   .:|..|...|
Human   411 TLTCEDPDS-VGATLDYKLWFRSSS---NPASLCLYDRVLEVNATLDCDTPGACFQHAASILVLD 471

  Fly   955 GGSPVLSSEALVYVLVDDVNDNAPVFGVQEYIFKVREDLPRGTVLAVIEAVDEDIGPNAEIQFSL 1019
            ||.|.:::|..|.|:|..:|:.:|....:  .|:|:||....|:|..:...|.|. |:..|::  
Human   472 GGQPQMTTEVPVLVMVTPINEFSPACAPR--TFRVQEDAAPHTLLGSVVGTDMDY-PHDNIEY-- 531

  Fly  1020 KEETQDEELFRIDKHTGAIRTQGYLDYENKQVHNLIVSAIDGG---DPS--LTSDMSIVIMIIDV 1079
             ..:.....|.:|:.:|.:...|.||||.::::.|.|..||.|   :|:  |:...:|.|.:.||
Human   532 -YTSGGPTTFAVDRLSGEVHLLGPLDYEQQRLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDV 595

  Fly  1080 NENRFAPEFDDFVYEGKVKENKPKGTFVMNVTARDMDTVDLNSKI---------TYSITGGDGLG 1135
            |::  |||.:....|..:  ..|.|        |.::...::.:|         :|||.||:...
Human   596 NDH--APECEPPFQELTI--YAPLG--------RSVEVTKMSCQIPQEPQRLIYSYSIVGGNSQN 648

  Fly  1136 IFAVNDQGSITSLSQLD-----AETKNFYWLTLCAQDC--AIVPLSNCVEVYIQV---------- 1183
            .|.:  ||:|...|.|.     .|....|.|.:|..|.  :...||....:.:.:          
Human   649 RFIL--QGAILVHSDLVLGPFWPEQPRTYELLICVADAGPSTPHLSTTATIIVHLVPRRASTVAT 711

  Fly  1184 ENENDNIPLTDKPVYYVNVTEA 1205
            ......:|.|..|: .|..|||
Human   712 STHRTTVPSTMTPM-LVTDTEA 732

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
E_set 309..390 CDD:298831
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637 19/102 (19%)
Cadherin_repeat 776..873 CDD:206637 21/99 (21%)
Cadherin_repeat 883..976 CDD:206637 30/100 (30%)
Cadherin_repeat 984..1082 CDD:206637 30/102 (29%)
Cadherin_repeat 1092..1189 CDD:206637 23/122 (19%)
Cadherin_repeat 1197..1295 CDD:206637 4/9 (44%)
Cadherin_repeat 1303..1386 CDD:206637
Cadherin_repeat 1413..1502 CDD:206637
Cadherin_repeat 1510..1608 CDD:206637
Cadherin_repeat 1621..1713 CDD:206637
Cadherin_repeat 1724..1811 CDD:206637
Cadherin_repeat 1819..1927 CDD:206637
Cadherin_repeat 1948..2030 CDD:206637
Cadherin_repeat 2037..2136 CDD:206637
Cadherin_repeat 2144..2235 CDD:206637
Cadherin_repeat 2246..2336 CDD:206637
Cadherin_repeat 2345..2445 CDD:206637
Cadherin_repeat 2453..2545 CDD:206637
Cadherin_repeat 2555..>2633 CDD:206637
Cadherin_repeat 2658..2759 CDD:206637
Cadherin_repeat 2774..2856 CDD:206637
Cadherin_repeat 2865..2963 CDD:206637
Cadherin_repeat 2974..3063 CDD:206637
Cadherin_repeat 3072..3165 CDD:206637
Cadherin_repeat 3173..3269 CDD:206637
Cadherin_repeat 3277..3374 CDD:206637
Cadherin_repeat 3383..3479 CDD:206637
Cadherin_repeat 3488..3579 CDD:206637
Cadherin_repeat 3590..3681 CDD:206637
EGF_CA 3866..3903 CDD:238011
Laminin_G_2 3953..4077 CDD:280389
EGF_CA <4121..4150 CDD:238011
EGF_CA 4152..4189 CDD:238011
EGF_CA 4195..4225 CDD:238011
EGF_CA 4227..4262 CDD:214542
CDHR4XP_016861855.1 Cadherin_repeat 294..384 CDD:206637 18/95 (19%)
Cadherin_repeat 398..492 CDD:206637 29/97 (30%)
Cadherin_repeat 499..598 CDD:206637 30/104 (29%)
Cadherin_repeat <638..702 CDD:206637 18/65 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1219
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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