DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kug and shg

DIOPT Version :9

Sequence 1:	NP_001027138.2	Gene:	kug / 40191	FlyBaseID:	FBgn0261574	Length:	4699	Species:	Drosophila melanogaster
Sequence 2:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster

Alignment Length:	1452	Identity:	355/1452 - (24%)
Similarity:	592/1452 - (40%)	Gaps:	295/1452 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  2815 QQTLDREQQESHNL------------IVVAETSTVPVFFAYADVLIDVRDENDN-YPKFDN-TFY 2865
            |||..:.:::..:|            ::||.:...|....::..  |.....|| .|.|.| ..|
  Fly    31 QQTHQQHKRKCRDLGRRLIPARLLLGVIVAISLLSPALALHSPP--DKNFSGDNRKPAFKNCAGY 93

  Fly  2866 SASVAENSEKVISLVKVSATDADTGPNGDIRYYLESDTENIQNIFD-----IDIYSGWITLLTSL 2925
            :..|.|...:...::.|.|.|.|  |:..|||.:      :|:.|:     |:..:|.|....:.
  Fly    94 APKVKEEQPENTYVLTVEAVDPD--PDQVIRYSI------VQSPFERPKFFINPSTGVIFTTHTF 150

  Fly  2926 DRE--VQSEYNFKVI-AADNGHPKHDAKVPVTIKIVDYNDNAPVFKLPIEGLSVFENALPGTVLI 2987
            ||:  :..::.|..: |.|||.|..|......:.|.|.|||||.|.......|:.|||.|..|::
  Fly   151 DRDEPIHEKFVFVTVQATDNGLPPLDDVCTFNVTIEDINDNAPAFNKARYDESMSENAQPDAVVM 215

  Fly  2988 NLLLIDPDIEKQEMDFFIVSGDKQAQ-FQIGK-SGELFIAKPLDREQLMFYNLSI----IATDGK 3046
            .:...|.|.....:..:.:..::..| |:|.| ||.:::.:|:|:.....|.:.:    :..|..
  Fly   216 TISASDFDDGNNSLVEYEILRERDFQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPDPP 280

  Fly  3047 FTAKANVEIDVKD--------IND-NTPYCLKPR-----YHISTNESISIGTTLVEVKAIDFDFQ 3097
            ..|:..|.|.|.:        :|. :||..||..     :.|:|..::|   .:.:...:.|:..
  Fly   281 QDAQIEVRIRVVESSIKPPSFVNPIDTPIYLKENLKNFTHPIATLRAVS---NMPDKPEVIFELN 342

  Fly  3098 SKLRFYLSGKGADDFS-IGKESGILKVASALDRETTPKYKLVAHVQDGKDFTQECFSEIIITVND 3161
            :......:.|....|: ||.|..| .:...||.|....|.|...|::..:...|  .:|.|.|.|
  Fly   343 TGRTEQTNSKNTFVFNQIGNEVTI-SLGKTLDYEAITDYTLTMIVRNTHELGTE--HQIKIQVED 404

  Fly  3162 INDNMPIFSMAQYRVSVPEDAQLNTLITKVHAMDKD-FGVNRQIKYSLMGENHDYFKISKSTGII 3225
            :|||:|.::..: ..::.|:....|.:.:|.|.|.| ...|..:.:.| .:|.:||.|..:||.|
  Fly   405 VNDNIPYYTEVK-SGTILENEPPGTPVMQVRAFDMDGTSANNIVSFEL-ADNREYFTIDPNTGNI 467

  Fly  3226 RLHKSLDRETISLFNLTVKAEDCGVPKL---------HSIATVAVNILDINDNPPEFSMRQYSC- 3280
            ....:.|||....:|:.|.|.|.....|         |.:..:::.  |.||:.|.|...:|..
  Fly   468 TALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIG--DKNDHKPHFQQDKYLAE 530

  Fly  3281 KILENATHGTEVCKVYATSIDIGVNA-DIHYFIMSGNEQGKFKMDSTTGDLVLNATLDYEMSKFY 3344
            ::||:|...|||.:|.|...|   || .|.|.|.|||....||:...||.:.:|..||||....|
  Fly   531 RLLEDANTNTEVIEVKAEDED---NASQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEY 592

  Fly  3345 FLTIQAIDGGTPPLSNNAYVNISILDINDNSPTFLQNLYRINVNEDIFVGSKILDVKATD---ED 3406
            .|.::|.||   ...:...|.|.|.|:|||.|.|.|: |.:.:.|:......||.|:|.|   :|
  Fly   593 ELKVRAFDG---IYDDYTTVVIKIEDVNDNPPVFKQD-YSVTILEETTYDDCILTVEAYDPDIKD 653

  Fly  3407 SDVNGLVTYNIERGDNIGQFSIDPKNGTISVSRPLDRETIS---HYTLEIQACDQ-GDPQRCNSV 3467
            .:.:..:.|:|.:.|. .:::|| .:|.:.:.:.|||:..:   ::.:.|:|.|: |.....::|
  Fly   654 RNADQHIVYSIHQNDG-NRWTID-NSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVSTV 716

  Fly  3468 -PININILDTNDNAPIFSSSNYSVVLQENRLLGYVFLTFKISDADETPNTTPYTFDIRSGNEGGL 3531
             .:.:.:.|.||||| |..:...|..||||..|:| :..:.:|.|:||....:||.|.|.....:
  Fly   717 KEVTVTLKDINDNAP-FLINEMPVYWQENRNPGHV-VQLQANDYDDTPGAGNFTFGIDSEATPDI 779

  Fly  3532 -FRLEQDGS-LRTASRFNHNLQDEFVIQVRVFDNGTPPLYSDAWVVVKIIEESQYPPIVTPLEVT 3594
             .:...||. |....:|:...|.|:.|.:|:.|:|.|  ...|..::.::..          :|.
  Fly   780 KTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVP--RQSAVSILHLVIG----------DVN 832

  Fly  3595 INSFEDDFSGAF------------IGKVHASDQDKYD--ELNFSLVSGPDDMYQSSKLFNISNNT 3645
            .|:..:..|..|            ||:|...|.|.:|  :..|.....|.|.      |.::.:|
  Fly   833 DNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQ------FRLNPST 891

  Fly  3646 GKIYAISNLDIGLYKLN-VSVSDGKFHVFSIVKINVELVTNDMLKESV----VIRFRRISASEFL 3705
            |.|..:.:...|.|.|: |...|..|.....|...|.:|..::.:|:|    .|||..::..||:
  Fly   892 GMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFI 956

  Fly  3706 -------------------LSHRKTFMRSIRNIMRCRQKDVILITLQSDYQKASQHAVGNRRARS 3751
                               ||..|.|..|:.|:      ||..: ||::
  Fly   957 SVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNV------DVFTV-LQNE---------------- 998

  Fly  3752 IDSDLNVVFAVRKQQIIPDSDEFFTSDEIRQTLIDKKNEIENETNLVVEDVLPSTCQSNKNDCVH 3816
             :..|:|.|:..       ...::..:::...:...:..:|||.:|.:..|....|...|..| .
  Fly   999 -NHTLDVRFSAH-------GSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKC-E 1054

  Fly  3817 GECKQILQILKNNV-------TTTFTDVISFAAPSYIPVNTCVCRPGFDGKHCKETVNACSTDPC 3874
            ..|..  ::.|::|       ||:|..|.:|....      |||.
  Fly  1055 ESCTN--ELHKSSVPYMIYSNTTSFVGVNAFVQAQ------CVCE-------------------- 1091

  Fly  3875 SP-QRICMPSGSALGYQ---CVCPKGFSGTYCERKSSKCSNESCDMGLFTAVSFGGKSYAHYKIN 3935
            :| .|.|:..||....:   |.|..||:|.:||               ..:|:|.|..||.|:
  Fly  1092 APLMRRCLNGGSPRYGENDVCDCIDGFTGPHCE---------------LVSVAFYGSGYAFYE-- 1139

  Fly  3936 KVKAKFTLENGFSYSLQIRTVQQTGTLLYASGKVDYN---------ILEIINGAVQYRFDLGSGE 3991
                .....|....||:|......|.::|. |.:::|         .||:.||......|.|||.
  Fly  1140 ----PIAACNNTKISLEITPQIDQGLIMYL-GPLNFNPLLAISDFLALELDNGYPVLTVDYGSGA 1199

  Fly  3992 GVISVSSINISDGEWHQISLERSLNSAKVMVDNKHVSH----GSAPGVNGILNIQSNDIFVGAEV 4052
            ..|....|.:.....:|:.:.....|.::.|||..:|.    |:..|.|..||       |.|.:
  Fly  1200 IRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNEFLN-------VNAPL 1257

  Fly  4053 RPHPSIIGYEDI-----------QRGFIGCMANIKIAKESLPLYISGGSTIAALKRFTNVEFKCD 4106
            :...:.:..|.:           |:||.||:.|:.|.:::   |..|..::     |.|::..|.
  Fly  1258 QLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQT---YNLGMPSV-----FRNIDSGCQ 1314

  Fly  4107 PS-----------NVLVRLGIC 4117
            .|           |.::.:.:|
  Fly  1315 QSVAVAFSFGIDRNFIIAIIVC 1336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kug	NP_001027138.2	Cadherin_repeat	66..178	CDD:206637
		Cadherin_repeat	187..285	CDD:206637
		E_set	309..390	CDD:298831
		Cadherin_repeat	404..503	CDD:206637
		Cadherin_repeat	513..609	CDD:206637
		Cadherin_repeat	622..708	CDD:206637
		Cadherin_repeat	776..873	CDD:206637
		Cadherin_repeat	883..976	CDD:206637
		Cadherin_repeat	984..1082	CDD:206637
		Cadherin_repeat	1092..1189	CDD:206637
		Cadherin_repeat	1197..1295	CDD:206637
		Cadherin_repeat	1303..1386	CDD:206637
		Cadherin_repeat	1413..1502	CDD:206637
		Cadherin_repeat	1510..1608	CDD:206637
		Cadherin_repeat	1621..1713	CDD:206637
		Cadherin_repeat	1724..1811	CDD:206637
		Cadherin_repeat	1819..1927	CDD:206637
		Cadherin_repeat	1948..2030	CDD:206637
		Cadherin_repeat	2037..2136	CDD:206637
		Cadherin_repeat	2144..2235	CDD:206637
		Cadherin_repeat	2246..2336	CDD:206637
		Cadherin_repeat	2345..2445	CDD:206637
		Cadherin_repeat	2453..2545	CDD:206637
		Cadherin_repeat	2555..>2633	CDD:206637
		Cadherin_repeat	2658..2759	CDD:206637
		Cadherin_repeat	2774..2856	CDD:206637	8/52 (15%)
		Cadherin_repeat	2865..2963	CDD:206637	28/105 (27%)
		Cadherin_repeat	2974..3063	CDD:206637	23/103 (22%)
		Cadherin_repeat	3072..3165	CDD:206637	22/93 (24%)
		Cadherin_repeat	3173..3269	CDD:206637	26/105 (25%)
		Cadherin_repeat	3277..3374	CDD:206637	37/98 (38%)
		Cadherin_repeat	3383..3479	CDD:206637	24/103 (23%)
		Cadherin_repeat	3488..3579	CDD:206637	27/92 (29%)
		Cadherin_repeat	3590..3681	CDD:206637	24/105 (23%)
		EGF_CA	3866..3903	CDD:238011	10/40 (25%)
		Laminin_G_2	3953..4077	CDD:280389	35/147 (24%)
		EGF_CA	<4121..4150	CDD:238011
		EGF_CA	4152..4189	CDD:238011
		EGF_CA	4195..4225	CDD:238011
		EGF_CA	4227..4262	CDD:214542
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637	28/105 (27%)
		Cadherin_repeat	200..292	CDD:206637	21/91 (23%)
		CA	332..410	CDD:214520	21/80 (26%)
		Cadherin_repeat	417..518	CDD:206637	26/103 (25%)
		Cadherin_repeat	531..619	CDD:206637	36/93 (39%)
		Cadherin_repeat	627..729	CDD:206637	24/103 (23%)
		Cadherin_repeat	736..834	CDD:206637	28/110 (25%)
		LamG	1127..1294	CDD:238058	44/180 (24%)
		Cadherin_C	1358..1489	CDD:279398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24026
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010