DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kug and Fat4

DIOPT Version :9

Sequence 1:	NP_001027138.2	Gene:	kug / 40191	FlyBaseID:	FBgn0261574	Length:	4699	Species:	Drosophila melanogaster
Sequence 2:	XP_006232354.2	Gene:	Fat4 / 310341	RGDID:	1564291	Length:	4981	Species:	Rattus norvegicus

Alignment Length:	5250	Identity:	1349/5250 - (25%)
Similarity:	2125/5250 - (40%)	Gaps:	1156/5250 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 TIPENSLGKTYAKGVLHERLAGLRVGLNAEVKYRIISGDKEKLFKAEEKL--VGDFAFLAIRTRT 132
            |..::.:|   :.||.|.             .|||:.|::...|:.:..|  .|:.|||.:.::.
  Rat   158 TATDSDIG---SNGVDHR-------------SYRIVRGNEAGRFRLDITLNPSGEGAFLHLVSKG 206

  Fly   133 NNVVLNREKTEEYVIRVKAHVHLHDRNVSSYETEANIHIKVLDRNDLSPLFYPTQYTVVIPEDTP 197
            .   |:||.|.:|.:.|:    :.|:..........:::.|.|.||..|:|..:.|...:|||..
  Rat   207 G---LDREVTPQYQLLVE----VEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAV 264

  Fly   198 KYQSILKVTADDADLGINGEIYYSLLMDSEYFAIHPTTGEITLLQQLQYAENSHFELTVVAYDRG 262
            ...|:|:|.|.|||.|.|.:|.|.|..:...|.:.|.||.||:.:.|.:.....:.|||.|.|||
  Rat   265 VGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQATDRG 329

  Fly   263 SWVNHQNHQASKTKVSISVKQVNFYAPEIFTKTFSSVTPTSNPLIYGIVRVNDKDTGINGNIGRL 327
                                             ..|:|..:..||. ::.|||.|..:
  Rat   330 ---------------------------------VPSLTGRAEALIQ-LLDVNDNDPVV------- 353

  Fly   328 EIVDGNPDGTFLLKAAETKDEYYIELNQFAHLNQQHFIYNLTLLAEDLGTPRRFAYKSVPIQIKP 392
                              |..|:...:::|
  Rat   354 ------------------KFRYFPATSRYA----------------------------------- 365

  Fly   393 ESKNIPIFTQEIYEVSIPETAPINMPVIRLKVSDPDL-GKNALVYLEIVGGNEGDEFRIN----P 452
                           |:.|.|.:...|..|.|:|.|. ..|..:.::|:||||...|.:.    |
  Rat   366 ---------------SVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQRSKVP 415

  Fly   453 DSGMLYTAKQLDAEKKSSYTLTVSAIDQ------ANVGSRKQSSAKVKISVQDMNDNDPIFENVN 511
            :..::..|..||.|:..||.||||..|.      |.|.:| .|.|.:.|.|.|:||:.|:||...
  Rat   416 NLSLIKVASALDRERIPSYNLTVSVSDNSGAPPTAEVQAR-SSVASLVIFVNDINDHPPVFEQQV 479

  Fly   512 KVISINENNLAGSFVVKLTAKDRDSGENSYISYSIANLNAVP-FEIDHFSGIVKTTSL--LDFET 573
            ..::::|....||:|..::|.|.|||.|:.:.|||.:.|.:. |.|...||:|.|::.  ||.|
  Rat   480 YRVNLSEEVPPGSYVSGVSATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTSAAGGLDRE- 543

  Fly   574 MKRNYELIIRASDWGLPYRRQTEIKLSIVVKDINDNRPQFERVNCYG-KVTKSAPMGTEVFVTSA 637
            :.....|.|.|.|.|: :.:.:..:|.:.|.|:||.:|.|.:...|. .|.::||.|||:.|..|
  Rat   544 LASQIVLNISARDQGV-HPKVSYAQLVVSVLDVNDQKPVFSQPEGYEVSVVENAPTGTELLVLGA 607

  Fly   638 IDFDAGD--IISYRLSDGNED-GCFNLDPTSGSLSISCDLKKTTLTNRILKVSATDGTHFSDDLI 699
            .|.|.||  .:.:.|.:...| ..|.|||.||.||....|.:.......|.:.||
  Rat   608 TDGDLGDNGTVRFSLQEAESDQRLFRLDPVSGRLSTISSLDREEQAFYCLLILAT---------- 662

  Fly   700 INVHLMPEDLGGDSSILHGFGSFECRETGVARRLAETLSLAEKNNVKSASPSVFSDLSLTPSRYG 764
                    |||                                      ||...|.:.:..|...
  Rat   663 --------DLG--------------------------------------SPPQSSTVQVNVSLLD 681

  Fly   765 QNVHRPEFVNFPQELSINESVQLGETVAWIEAKDRDLGYNGKLVFAISDGDYDSVFRIDPDRGEL 829
            .|.:.|.|........|.|:...|..|..:.|.|.|:|.||.:.::||.|| .|.|:|....|.:
  Rat   682 INDNSPVFYPVQYFAHIQENEPGGSYVTTVSATDPDMGPNGTVKYSISAGD-RSRFQIHAKSGVI 745

  Fly   830 QIIGYLDRERQNEYVLNITVYDLGNPTKSTSKMLPITILDVNDNRPVIQKTLATFRLTESARIGT 894
            .....||||.:..|.|.|...|.||....:..::.:|:||..||.||..:...:|.:.|:..:|.
  Rat   746 STKMALDREEKTAYQLQIVATDGGNLQSPSQAIVTVTVLDTQDNPPVFSQAAYSFVVFENVALGY 810

  Fly   895 VVHCLHATDADSGINAQVTYALSV--ECSDFTVNATTGCLRLNKPLDREKQDNYALHITAKDGGS 957
            .|..:.||..|  :||.::|.::.  :...|.:|..||.|.....:|||:|..|.|.:.|..|
  Rat   811 HVGSVSATTMD--LNANISYLITTGDQRGMFAMNPVTGQLTTASVIDREEQSFYQLRVVASGG-- 871

  Fly   958 PVLSSEALVYVLVDDVNDNAPVFGVQEYIFKVREDLPRGTVLAVIEAVDEDIGPNAEIQFSLKEE 1022
             .::.:|:|.:.|.|:|||||.|..........|:...|..:...:|||.|.|.|..:.:|||:.
  Rat   872 -AVTGDAVVNITVKDLNDNAPHFLQAVESIDAVENWQAGHSIFQAKAVDPDEGVNGRVLYSLKQN 935

  Fly  1023 TQDEELFRIDKHTGAIRTQGYLDYENKQVH----NLIVSAIDGGDPSLTSDMSIVIMIIDVNENR 1083
            .::  ||.|::..|.|...|.||     ||    .:.:.|.|.|.|.|:|.:.:.:.:.|||:|
  Rat   936 PKN--LFTINEQNGNISLLGTLD-----VHAGSYQVEIVASDMGVPQLSSSIILTVYVHDVNDN- 992

  Fly  1084 FAPEFDDFVYEGKVKENKPKGTFVMNVTARDMDTVDLNSKITYSITGGDGLGIFAVNDQGSITSL 1148
             .|.||...||..:.|::|..:....|.|.|.|: ..|.:|.|:||.|:....|.:...|.:...
  Rat   993 -PPVFDQISYEVTLSESEPVNSRFFKVQALDKDS-GANGEIAYAITDGNSGEAFGIFPDGQLYIK 1055

  Fly  1149 SQLDAETKNFYWLTLCAQDCAIVPLSNCVEVYIQVENENDNIPLTDKPVYYVNVTEASVENVEII 1213
            |:||.|.::.|.|.:.|.|.|:.|||..|.|.:.:|:.|||.||.:...|.....|.......:.
  Rat  1056 SELDRELQDRYVLLVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVG 1120

  Fly  1214 TLKAFDPDIDPTQTITY--NIVSGNLVGYFEIDSKTGVIKTTERKLDREN------QAEHILEVA 1270
            .:.|.|.|..|...:.|  .:...:    ||:.:.||.| |...|.|||:      .|.....|.
  Rat  1121 KVSAVDKDFGPNGEVRYAFEVAQPD----FELHAITGEI-TNTHKFDRESLMRRRGTAVFSFTVI 1180

  Fly  1271 ISDNGSP-VLSSTSRIVVSVLDINDNSPEFDQRVYKVQVPSSATVNQSIFQVHAIDSDSGENGRI 1334
            .:|.|.| .|...:.:.|.:.|||||:|:|.:..|:..|..:||....:.:|.|.|.|.|.||.|
  Rat  1181 ATDQGLPQPLKDQATVHVYMKDINDNAPKFLKDFYQATVSETATNLTQVLRVSASDVDEGNNGLI 1245

  Fly  1335 TYSIKSGKGKNKFRIDSQRGHIHIAKPLD--SDNEFEIHIKAEDNGIPKKSQTARVNIVVVPVNP 1397
            .|||..|..:.:|.||...|.:.:...||  :...:.:.|:|.|:|....:.|..::|.::..|.
  Rat  1246 HYSILKGNEERQFSIDRFSGQVTLVGKLDYEATPAYSLLIQAVDSGTVPLNSTCTLSIDILDEND 1310

  Fly  1398 NSQNAPLIVRKTSENVVDLTENDKPGFLVTQILAVDDD---NDQLWYNISNGNDDNTFYIGQDNG 1459
            |:.:.|     .|...||:.||.:.|.||:.:.|.|.|   |..|.|.|:..|:..||.|..:.|
  Rat  1311 NTPSFP-----KSTLFVDVLENMRIGELVSSVTATDSDSGVNADLHYTITGSNNHGTFSISPNTG 1370

  Fly  1460 NILLSKYLDYETQQSYNLTISVTD---GTFTAFTNLLVQVIDINDNPPQFAKDVYHVNISENIEE 1521
            :|.|:|.||:|||..|.|.|:..|   ...::..::::.|.|.|||||.|.......:|.|||..
  Rat  1371 SIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPL 1435

  Fly  1522 ESVIMQLHATDRDED--KKLFYHLHATQDPSSLALFRIDSISGNVIVTQRLDFEKTAQHILIVFV 1584
            .:.::.:.|.|.|.|  .:|.|.: ..|.|.. ..|.||.:.|.:..:..:|.|......|.|..
  Rat  1436 GTSVISVTAHDPDADINGQLSYAI-IQQMPRG-NHFSIDEVKGTIYTSAEIDREFANLFELTVKA 1498

  Fly  1585 KDQGAP-GKRNYA--KIIVNVHDHNDHHPEFTAKIIQSKVPESAAIGSKLAEVRAIDRDSGHNAE 1646
            .||..| ..|.||  .:.:.|.|.||:.|.|.::...:..| ||.|||.|..:.|.|.|.|.|.|
  Rat  1499 NDQAVPIETRRYALKNVTILVTDLNDNVPIFISQNALAADP-SAMIGSVLTTIMAADPDEGANGE 1562

  Fly  1647 IQYSIITGNVGSVFEIDPTFGIITLAGNLNINKIQEYMLQVKAVDL------------------- 1692
            ::|.|:.|:. ..|.:|...|.:.:|..|..::: .|.|.|.|.||
  Rat  1563 VEYEIVNGDT-DTFTVDRYSGDLRVASALVPSQL-IYNLIVSATDLGPERRKSTTELTVILQGLD 1625

  Fly  1693 ---------------GNP------------PLSSQIPV--------------------------- 1703
                           |.|            |..|:.||
  Rat  1626 GPVFTQTKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRQTGVI 1690

  Fly  1704 ----------------------------------HIIVTMSE-ND-PPKFPTNNIAIEIFENLPI 1732
                                              .:.:|:.: || ||.|||:.:.:.:.||:..
  Rat  1691 QTAAILDREQGACLYLVDVYAIEKSSAFPRTQRAEVEITLQDINDNPPVFPTDTLDLTVEENIGD 1755

  Fly  1733 GTFVTQVTAR-----SSSSIFFNIISGNINESFRINPSTGVIVINGNIDYESIKVFNLTVKGTNM 1792
            |:.:.|:||.     :::.:.:.:||| .::||||:|.:|.::....:|.|....::|.|:..:
  Rat  1756 GSKIMQLTAMDADEGANALVTYALISG-ADDSFRIDPESGDLIATKRLDREHRSKYSLLVRADD- 1818

  Fly  1793 AAESSCQNIIIHILDANDNIPYFVQNEYVGALPESAAIGSYVLKVHDSSKDHLTLQVKDADVGVN 1857
            ..:||...|.|.|.|.||:.|.|.:..|...:||....||.|          ..:...|.|.|||
  Rat  1819 GLQSSDMRINITISDVNDHTPRFSRPVYSFDIPEDTTPGSLV----------AAILATDDDSGVN 1873

  Fly  1858 GMVEYHIVDDLAKNFFKIDSTTGAIELLRQLDYETNAGYTFDVTVSDMGKPKLHSTTTAHVTIRV 1922
            |.:.|.:.:|.....|.::..||...|.|.||||....|...|...|.|    ...||......:
  Rat  1874 GEISYVVEEDDGDGVFFLNPVTGVFNLTRALDYERQQYYILTVRAEDGG----GQFTTIRAYFNI 1934

  Fly  1923 INVNDCPPVFNERELNVTLF--LPTFENVFVRQVS-AKDADNDTLRFDIVDGNTNECFQIEKYTG 1984
            :::||.||||:....:.:|.  ||....|.|..|: |.|..|..|.:.|..|::...|.::|: |
  Rat  1935 LDINDNPPVFSLSSYSTSLMENLPLGSTVLVFNVTDADDGVNSQLSYSIASGDSLGQFAVDKH-G 1998

  Fly  1985 IITTRNFEILNNENDRDYALHVRASD------GIFSAILIVKIKVLSAIDSNFAFQRESYRFSAF 2043
            ::  :..:.|:.|:...|.|.::..|      ..|::...|.|.:|...|:...|.  |.:.:..
  Rat  1999 VL--KALKALDRESQSFYNLVIQVHDLPQPPASRFTSTAQVSIILLDVNDNPPMFL--SPKLTYI 2059

  Fly  2044 ENNTKVATIGLVNVIGNTLDEN----VEYRILNPT-QLFDIGISSGALKTTGVIFDREVKDLYRL 2103
            ..||.:.|: :........|..    :||.:|||. ..|.||...|.:..||.: |||....|.|
  Rat  2060 PENTPIDTV-VFKAQATDPDSGPNSYIEYTLLNPAGNKFSIGTIDGEVHLTGEL-DREEVSNYSL 2122

  Fly  2104 FVEAKSMLYDGMNSNVRRAVTSIDISVLDVNDNCPLFVNMPYYATVSIDDPKGTIIMQVKAIDLD 2168
            .|.|.......::|:     |.:.:.|||:|||.|:|....|...:..:...||.|:||.|.|.|
  Rat  2123 TVVATDKGQPPLSSS-----TEVVVMVLDINDNNPVFAQAMYRVQIKENTLTGTDIIQVSAADND 2182

  Fly  2169 SAENGEVRYELKKGN-GELFKLDRKSGELSIKQHVEGHN-RNYELTVAAYDGAITPCSSEAPLQV 2231
            ...||:|||.:..|| .:.|::|..:|.:::.:.::... ..|.|||.|.|...:|.:....:.:
  Rat  2183 EGTNGQVRYGIVGGNTHQEFRIDSVTGAITVAKSLDRETIPAYILTVQATDRGSSPRTDSCTVAI 2247

  Fly  2232 KVIDRS--MPVFEKQFYTVSVKEDVEMYSALSVSIEA----ESPLGRSLIYTI--SSESQSFEID 2288
            .::|.:  :||||...|:|:|.|::.......:.:.|    :.| ...|.|.:  .:|..:|.:.
  Rat  2248 TLLDMNDFVPVFELSPYSVNVPENLGALPRTILQVVARDDDQGP-NSQLSYVLLGGNEDNAFALT 2311

  Fly  2289 YNTGSIFVVNELDYEKISSHDVSIRATD----SLSGVYAEVVLSVSIMDVNDCYPEIESDIYNLT 2349
             .:|.:.|...||.|......:.:.|.|    :|:|.   ..:::.:.|:||..|...|::|...
  Rat  2312 -ASGELRVTQSLDREARDHFVLVVTAADAGSPALTGT---GTINIIVDDINDNVPTFASNMYFTA 2372

  Fly  2350 IPENASFGTQILKINATDNDSGANAKLSYYIESINGQNNSELFYIDVTDGNLYLKTPLDYEQIKY 2414
            |||:|..||.:|.:||:|.|:..||.:||   ||.|.|:.  |.|:.:.|.:.....||.|....
  Rat  2373 IPEDAPTGTDVLLVNASDADAATNAVISY---SIIGGNSQ--FTINPSTGQIITSALLDRETKDN 2432

  Fly  2415 HHIVVNVKDHGSP-SLSSRSNVFITVKDLNDNAPCFVEPSYFTKVSVAAVRGQFVALPKAYDKDI 2478
            :.:||...|.||| ||||.::|.::|.|:|||.|.|....|.|.:......|.||......|.||
  Rat  2433 YTLVVVASDAGSPESLSSSTSVLVSVTDVNDNPPRFQHHPYVTHIPSPTPPGSFVFAVTVTDADI 2497

  Fly  2479 SDTDSLEYKIVYGNELQTYSIDKLTGVISLQNML----------------NFTDKSSTVLNISVS 2527
            .....|.|.: .|...:.:.||.|.|.|.....|                :|....||.:.:..:
  Rat  2498 GPNSELHYSL-SGRNSEKFHIDPLRGAIMAAGPLSGASEVTFSVHVKDGGSFPKTDSTTVTVRFA 2561

  Fly  2528 DGVHTAYARLKISLLPENVYSPLFDQSTYEAQVPENLLHGHNIITVKASD--GDFGTYANLYYEI 2590
            :.......|.|              :.|:  ..|||...|..:.|:..|.  |:     .|.|.|
  Rat  2562 NKADFPKVRAK--------------EQTF--MFPENQPVGTLVTTITGSSLRGE-----TLSYYI 2605

  Fly  2591 VSEEMKKIFLIDQTTGVITSKVTFDREKKDEYVVLLKVSDGGGKF----GFASLKVIVVDVNDNV 2651
            .|..:...|.||..||.::.....|.||..:|:|.::..|||  |    .:..|.:.|:|:|||.
  Rat  2606 ASGNLGNAFQIDPLTGQVSISQPLDFEKIQKYIVWIEARDGG--FPPFSSYEKLDITVLDINDNA 2668

  Fly  2652 PYFLLKEYKMVVSTTVE--ANQTILTVKAKDDDIVDNGSVHFQIVQKSNDKAVKDVIEINEKTGD 2714
            |.|   |....||..:|  :.:.||||.|.|.|...||.:.::||..:.:.:    ..||..||:
  Rat  2669 PAF---EEDPFVSEILENLSPRKILTVSATDKDSGPNGQLAYEIVNGNQESS----FTINHATGE 2726

  Fly  2715 IVFKSKAESYGVNSYQFFVRASDRGEPQFHSEVPVSIEIIETDANIPTFEKSSVLLKII-ESTPP 2778
            |......:...::.|:..|::||:|.|...:.|.|.|.:::.:.|.|.|  |.:....: |::|.
  Rat  2727 IRSIRPLDREKISYYELTVKSSDKGSPSQSTSVKVIISVLDENDNAPRF--SQIFSAYVSENSPL 2789

  Fly  2779 GTVLTKL----HMIG-NYTFKFSIAADQDHFMIS-DSGELILQQTLDREQQESHNLIVVAETS-- 2835
            |..:|::    ..|| |...::|||.....|.|: ::|::::.:.|:||..:.:.:.|.|..|
  Rat  2790 GYTVTRVTTSDEDIGINAISRYSIADTALPFTINPNTGDIVISRPLNREDTDRYRIRVSAHDSGW 2854

  Fly  2836 TVPVFFAYADVLIDVRDENDNYPKFDNTFYSASVAENSEKVISLVKVSATDADTGPNGDIRYYLE 2900
            ||.     .||.|.|.|.|||.|:|....|.....|.:|....:.:|||||.|.|.||.:.|:::
  Rat  2855 TVS-----TDVTIFVTDINDNTPRFSRPSYYLDCPELTELGSRVTQVSATDPDEGSNGQVFYFIK 2914

  Fly  2901 SDTENIQNIFDIDIYSGWITLLTSLDREVQ-------------SEYNFKVIAADNGHPKHDAKVP 2952
            |.:|    .|.|:..:|.|     .:::|.             :.::|.|.|:|.|:|...::..
  Rat  2915 SKSE----YFRINATTGEI-----FNKQVLKYQNVSGFSNVNINRHSFIVTASDRGNPSLLSETT 2970

  Fly  2953 VTIKIVDYNDNAPVFKLPIEGLSVFENALPGTVLINLLLIDPDIE---KQEMDFFIVSGDKQAQF 3014
            |||..||.|||.|.|........|.:|...||.||.:..:| |.:   ..|:::|:.:|:...:|
  Rat  2971 VTINTVDSNDNPPQFLKNKYFTPVTKNVKVGTKLIKVTAVD-DKDFGLNSEVEYFVSNGNHLGKF 3034

  Fly  3015 QI-GKSGELFIAKPL--DREQLMFYNLSIIATD---GKFTAKANVEIDVKDINDNTPYCLKPRYH 3073
            :: ..:|.:.||..|  |..|..|  :.:.|.|   ...:::..:.|.|.:.|.:||...:....
  Rat  3035 KLDNDTGWISIASSLVSDLNQNFF--IRVTAKDKGNPPLSSQVVIHITVTEENYHTPEFSQSHIS 3097

  Fly  3074 ISTNESISIGTTLVEVKAIDFD-FQSKLRFYLSGKGADD--FSIGKESGILKVASALDRETTPKY 3135
            .:..||.|||:.:..|.|.|.| ..:.|..|....|.::  |:|...:|::.:|.|||.|.:.|:
  Rat  3098 ATIPESHSIGSVVRTVSARDRDTAMNGLISYNISSGNEEGIFAINSSTGVVTLAKALDYELSSKH 3162

  Fly  3136 KLVAHVQDGKDFTQECFSEIIITVNDINDNMPIFSMAQYRVSVPEDAQLNTLITKVHAMDKDFGV 3200
            ::.....||....:..:..:.::|.|:|||.|:|...::..:|.|:|...|.:..::|.|.|.|.
  Rat  3163 EMTISATDGGWVARTGYCSLTVSVIDVNDNSPVFVPDEFFPTVMENAPSGTTVIHLNATDADSGA 3227

  Fly  3201 NRQIKYSLMGENHDYFKISKSTGIIRLHKSLDRETISLFNLTVKA------EDCGVPKLHSIATV 3259
            |..|.|::...:.|.|.|..:||:|.....||.||...::|||||      |.|      |.|||
  Rat  3228 NAVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEEKC------SFATV 3286

  Fly  3260 AVNILDINDNPPEFSMRQYSCKILENATHGTEVCKVYATSIDIGVNADIHYFIMSGNEQGKFKMD 3324
            .:.::..|:..|.|..:.|..::.|.|..||.|.:|:|:..|:|.:.::||.|...:.:..|::.
  Rat  3287 NIQLMGTNEYVPRFVSKLYYFEVSEAAPRGTAVGEVFASDRDMGADGEVHYLIFGNSRKKGFQIH 3351

  Fly  3325 STTGDLVLNATLDYEMSKFYFLTIQA----------IDGGTPPLSNNAYVNISILDINDNSPTFL 3379
            ..||.:.::..||.|..:...|.:.|          ||..|        |||::||.|| .|.|.
  Rat  3352 KMTGQIYVSGLLDREKEERVSLKVLAKNFGNIRGADIDEVT--------VNITVLDAND-PPVFS 3407

  Fly  3380 QNLYRINVNEDIFVGSKILDVKATDEDSDVN-GLVTYNIERGDNIGQFSIDPKNGTISVSRPLDR 3443
            .|.||:.::|.:.:|:.:..|.|.|.||..: ...:|.|..|:..|.|||:|:.|.|:|:..|||
  Rat  3408 LNTYRVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTSGLDR 3472

  Fly  3444 ETISHYTLEIQACDQGDPQRCNSVPININILDTNDNAPIFSSSNYSVVLQENRLLGYVFLTFKIS 3508
            |::..|.|.:.|.|.|.|....|..:.:.:.|.|||.|:.:.|...|:  ||:..|.:.:|.:.:
  Rat  3473 ESLPVYNLTVLAVDSGTPSATGSASLLVTLEDINDNGPVLTVSEGEVL--ENKRPGTLVMTLQST 3535

  Fly  3509 DADETPNTTPYTFDIRS-GNEGGLFRLEQDGSLRTASRFNHNLQDEFVIQVRVFDNGTPPLYSDA 3572
            |.|..||..|:.:.:.| |.....|.|...|.|.|....:.....:|.:.|...|:|.|.:.|..
  Rat  3536 DPDLPPNQGPFNYYLLSTGPATNYFSLNTAGVLSTTREIDREQIADFYLSVVTRDSGAPQMSSTG 3600

  Fly  3573 WVVVKIIEESQYPPIVTPLEVTINSFEDDFSGAFIGKVHASDQDKYDELNFSLVSGPDDMYQSSK 3637
            .|.:.:::::..|.....:|:.:|.:.:.|.|..:|.|...|.|..|..:.||.||      .:.
  Rat  3601 TVHITVLDQNDNPSQSRTVEIFVNYYGNLFPGGTLGSVKPQDPDVLDSFHCSLTSG------VTS 3659

  Fly  3638 LFNISNNTGKIYAISNLDIGLYKLNVSVSDGKFHVFSIVKINVEL----VTNDMLKESVVIR--- 3695
            ||:|...:..:.:......|.:.|.|..|||   |.|.|..|:.:    .:|..:..|:::|
  Rat  3660 LFSIPAGSCDLSSQPRSTDGTFDLTVVSSDG---VHSTVTNNIRVFFAGFSNATIDNSILLRVGV 3721

  Fly  3696 -------------FRRISASE--------------------FLLSHRK-------------TFMR 3714
                         |.||::|:                    |||:..|             ||..
  Rat  3722 PTVKDFLTNHYLHFLRIASSQLTGLGTAVQLYAAYEENNRTFLLAAVKRNHNQYVNPSGVATFFE 3786

  Fly  3715 SIRNIMRCRQKDVILITLQSDYQKASQHAVGNRRARSIDSD----------------LNVVFAVR 3763
            ||:.|: .||..|                    :..|:|.|                |.|..|::
  Rat  3787 SIKEIL-LRQSGV--------------------KVESVDHDPCIHAPCQNGGSCLRRLAVGSALK 3830

  Fly  3764 KQQIIPDSDEFFTSDEIRQTLIDKKNEIENETNLVVEDVLPSTCQSNKNDCVHGECKQILQILKN 3828
            .|:.:|             .:|.....::......|.....|.|:.:.::|:...|        :
  Rat  3831 IQESLP-------------VIIVANEPLQPFQCKCVPGYAGSWCEVDIDECLPAPC--------H 3874

  Fly  3829 NVTTTFTDVISFAAPSYIPVNTCVCRPGFDGKHCKETVNACSTDPCSPQRIC--MPSGSALGYQC 3891
            |..|....|..|         :|.|..||.|:.|:..:|.|...||....:|  .|.    |:.|
  Rat  3875 NGGTCHNLVGGF---------SCSCSEGFTGRACERDINECLPSPCKHGAVCQNFPG----GFNC 3926

  Fly  3892 VCPKGFSGTYCERKSSKC------SNESCDMGL---FTAVSFG--GK-----SYAHYKINKVK-A 3939
            ||..|::|..||...:.|      :..||..|:   :....||  ||     ||...:::.:: .
  Rat  3927 VCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVESYYCHCPFGVFGKHCELNSYGFEELSYMEFP 3991

  Fly  3940 KFTLENGFSYSLQIRTVQQTGTLLY-----ASGKVDYNILEIINGAVQYRFDLGSGEGVISVSSI 3999
            .....|.:.| ::..|::....|||     ...:.::..|||....:::.::||||...::...
  Rat  3992 SLDPNNNYIY-VKFATIKSHALLLYNYDNQTGERAEFLALEIAEERLRFSYNLGSGTYKLTTMK- 4054

  Fly  4000 NISDGEWHQISLERSLNSAKVMVDNKHVSHGSAPGVNGILNIQSNDIFVGAEVRPHPSIIG---- 4060
            .:|||::|.:...|:..:|.:.||:  .|....||...:.|:..:|.:. .:|:|:...:|
  Rat  4055 KVSDGQFHTVIARRAGMAASLTVDS--CSENQEPGYCTVSNVAVSDDWT-LDVQPNRVTVGGIRS 4116

  Fly  4061 YEDI-QR-------GFIGCMANIKIAKESLPLYISGGSTIAALKRFTNVEFKCDPSNVLVRLGI- 4116
            .|.| ||       .|:||:  ::.|....||                     :||..|...||
  Rat  4117 LEPILQRKGHVESHDFVGCI--MEFAVNGRPL---------------------EPSQALAAQGIL 4158

  Fly  4117 ---------CGSQPCANSGICKELDTDVF---ECACQPRYSGKHCEIDLDPCSSGPCLFGGRCDY 4169
                     |...||.:.|.|    .|.:   :|.|....:||:||..:.|.::......||.||
  Rat  4159 DQCPRLEGTCARNPCQHGGTC----VDFWSWQQCQCMEGLTGKYCEKSVTPDTALSLEGKGRLDY 4219

  Fly  4170 H-----------------------GPN----------------------NYS------------- 4176
            |                       |.|                      ||:
  Rat  4220 HMSQSEKREYLLTQSIREATLEPFGVNSLEVKFRTRSENGILIHIQESSNYTTVKIKNGKVHFTS 4284

  Fly  4177 ----------------------------------------------------------------- 4176

  Rat  4285 DAGVAGKVERIIPEAYVADGHWHTFRISKNGSSTVLSVDRTHSRDVVHPTQDFGGIEVLSMSLGG 4349

  Fly  4177 ----------------CTCPI-------HLSGKR---------------CEYGKFCTPNPCKNGG 4203
                            |...:       ..|||.               |.....|..|||....
  Rat  4350 IPPNQAHRDTQTGFNGCIASVLYGGESLPFSGKHSLASISKTDPSVKIGCRGPNICASNPCWGDL 4414

  Fly  4204 ICEEGDGISHCMCRGYTGPTCEIDVDECENQPCGNGATCINEPG---SFRCICPSYLTGASC--- 4262
            :|........|:..|           :|.:.||.||.:|  |||   .:.|.||...||.:|
  Rat  4415 LCINQWYAYKCVPPG-----------DCASHPCQNGGSC--EPGLLSGYTCSCPESHTGRTCETV 4466

  Fly  4263 ----------------GDP-----LYS---NSISTKLKNFSIEHISGIISGVAVVLVIISCVLCC 4303
                            |.|     :.|   :.||..|  :::..|.|..: .|:.|:::|.:||
  Rat  4467 VACLGVLCPQGKVCKAGSPGGHVCVQSQGPDEISLPL--WAVPAIVGSCA-TALALLVLSLILC- 4527

  Fly  4304 VVLKRSSSSKRRNRLEKDKNKSSYKEANLN-SLVDKDN---YCKPNVKLSNLEVNQRPISYTAVP 4364
               .:......:|..|:.|.|...|:.:.| :..|.||   |..........|.|.:|   ..:.
  Rat  4528 ---NQCRGKMPKNPKEEKKPKEKKKKGSENVAFDDPDNIPPYGDDLAVRKQPEGNPKP---DIIE 4586

  Fly  4365 NDN--LVLSNRNFVNNLDILRSYGSAGDELENVPFEYQKVNRNKQHVNINSCHSTDAD--NAYKQ 4425
            .:|  |:....:..:|.:.:.|...|..|.|   .|:..::      |.:|...:|||  ..|||
  Rat  4587 RENPYLIFDETDIPHNSETIPSAPLASPEQE---IEHYDID------NASSIAPSDADIIQHYKQ 4642

  Fly  4426 EWCEQMHLRTFSENKLNNELKRDFGPSVSRFS-TGKLIQVEMPNVCHSSSANFVDYSALANGQ-- 4487
               .:.|...|               |:.|.| .|...|..||     ..|:.:.|...:.||
  Rat  4643 ---FRSHTPKF---------------SIQRHSPLGFARQSPMP-----LGASSLTYQPSSYGQAL 4684

  Fly  4488 -----YHWDCSDWVRKSHNPLPDITEVPGAEIADSSSLHSNDSNESKSKKAFFVHREDGDVDPTR 4547
                 .|..|     .:.|||                  |..|....||.:.|...     .|.|
  Rat  4685 RTSSLSHSAC-----PTPNPL------------------SRHSPAPFSKPSAFYRN-----SPAR 4721

  Fly  4548 DIAALNEDIGSEYLDSEAESCLEPFM------LPRSS----------NQPLSRLS---------- 4586
            ::.....|.|:  |:...:.| :|.|      |.|.|          ::|.|||.
  Rat  4722 ELHLPLRDGGT--LEMHGDPC-QPGMFNYATRLGRRSKSPQAMASHGSRPGSRLKQPIAQIPLES 4783

  Fly  4587 ------SFNNIENEDYKSNTVPLP------------SKVSHSCKVYL---RHPDSYLPTMHFPSE 4630
                  |...:|    :.|| |.|            |.....|:..|   |:|...:|.....|:
  Rat  4784 SPPVGLSIEEVE----RLNT-PRPRNPSICSADHGRSSSEEDCRRPLSRTRNPADGIPAPESSSD 4843

  Fly  4631 TDGESSMTEGPISRMEIKTRRTISENSEEAYLFPCTVGEIGSNSNISVRL 4680
            :|...|.|   .|.||....:.:...|....|......:.....|...||
  Rat  4844 SDSHDSFT---CSEMEYDREKPVVYTSRMPKLSQVNESDADDEDNYGARL 4890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kug	NP_001027138.2	Cadherin_repeat	66..178	CDD:206637	24/109 (22%)
		Cadherin_repeat	187..285	CDD:206637	30/97 (31%)
		E_set	309..390	CDD:298831	7/80 (9%)
		Cadherin_repeat	404..503	CDD:206637	36/109 (33%)
		Cadherin_repeat	513..609	CDD:206637	32/98 (33%)
		Cadherin_repeat	622..708	CDD:206637	26/88 (30%)
		Cadherin_repeat	776..873	CDD:206637	31/96 (32%)
		Cadherin_repeat	883..976	CDD:206637	28/94 (30%)
		Cadherin_repeat	984..1082	CDD:206637	30/101 (30%)
		Cadherin_repeat	1092..1189	CDD:206637	32/96 (33%)
		Cadherin_repeat	1197..1295	CDD:206637	27/106 (25%)
		Cadherin_repeat	1303..1386	CDD:206637	26/84 (31%)
		Cadherin_repeat	1413..1502	CDD:206637	34/94 (36%)
		Cadherin_repeat	1510..1608	CDD:206637	29/102 (28%)
		Cadherin_repeat	1621..1713	CDD:206637	34/199 (17%)
		Cadherin_repeat	1724..1811	CDD:206637	26/91 (29%)
		Cadherin_repeat	1819..1927	CDD:206637	29/107 (27%)
		Cadherin_repeat	1948..2030	CDD:206637	22/88 (25%)
		Cadherin_repeat	2037..2136	CDD:206637	29/103 (28%)
		Cadherin_repeat	2144..2235	CDD:206637	26/92 (28%)
		Cadherin_repeat	2246..2336	CDD:206637	20/99 (20%)
		Cadherin_repeat	2345..2445	CDD:206637	40/100 (40%)
		Cadherin_repeat	2453..2545	CDD:206637	22/107 (21%)
		Cadherin_repeat	2555..>2633	CDD:206637	24/79 (30%)
		Cadherin_repeat	2658..2759	CDD:206637	29/102 (28%)
		Cadherin_repeat	2774..2856	CDD:206637	27/89 (30%)
		Cadherin_repeat	2865..2963	CDD:206637	32/110 (29%)
		Cadherin_repeat	2974..3063	CDD:206637	24/97 (25%)
		Cadherin_repeat	3072..3165	CDD:206637	26/95 (27%)
		Cadherin_repeat	3173..3269	CDD:206637	33/101 (33%)
		Cadherin_repeat	3277..3374	CDD:206637	30/106 (28%)
		Cadherin_repeat	3383..3479	CDD:206637	33/96 (34%)
		Cadherin_repeat	3488..3579	CDD:206637	24/91 (26%)
		Cadherin_repeat	3590..3681	CDD:206637	26/90 (29%)
		EGF_CA	3866..3903	CDD:238011	12/38 (32%)
		Laminin_G_2	3953..4077	CDD:280389	34/140 (24%)
		EGF_CA	<4121..4150	CDD:238011	9/31 (29%)
		EGF_CA	4152..4189	CDD:238011	14/197 (7%)
		EGF_CA	4195..4225	CDD:238011	6/29 (21%)
		EGF_CA	4227..4262	CDD:214542	14/37 (38%)
Fat4	XP_006232354.2	Cadherin_repeat	48..131	CDD:206637
		Cadherin_repeat	139..246	CDD:206637	25/110 (23%)
		Cadherin_repeat	254..349	CDD:206637	36/128 (28%)
		Cadherin_repeat	364..471	CDD:206637	37/157 (24%)
		Cadherin_repeat	479..577	CDD:206637	31/99 (31%)
		Cadherin_repeat	588..685	CDD:206637	35/152 (23%)
		Cadherin_repeat	693..789	CDD:206637	31/96 (32%)
		Cadherin_repeat	798..889	CDD:206637	28/95 (29%)
		Cadherin_repeat	904..992	CDD:206637	30/94 (32%)
		Cadherin_repeat	1000..1096	CDD:206637	32/96 (33%)
		Cadherin_repeat	1105..1206	CDD:206637	27/105 (26%)
		Cadherin_repeat	1215..1311	CDD:206637	29/95 (31%)
		Cadherin_repeat	1321..1416	CDD:206637	34/94 (36%)
		Cadherin_repeat	1428..1525	CDD:206637	29/98 (30%)
		Cadherin_repeat	1540..1622	CDD:206637	26/83 (31%)
		Cadherin_repeat	1634..1736	CDD:206637	8/101 (8%)
		Cadherin_repeat	1747..1837	CDD:206637	26/91 (29%)
		Cadherin_repeat	1845..1940	CDD:206637	30/108 (28%)
		Cadherin_repeat	1948..2047	CDD:206637	24/101 (24%)
		Cadherin_repeat	2057..2150	CDD:206637	28/99 (28%)
		Cadherin_repeat	2159..2254	CDD:206637	27/94 (29%)
		Cadherin_repeat	2263..2360	CDD:206637	21/101 (21%)
		Cadherin_repeat	2369..>2443	CDD:206637	29/78 (37%)
		Cadherin_repeat	2472..2559	CDD:206637	20/87 (23%)
		Cadherin_repeat	2573..2667	CDD:206637	30/102 (29%)
		Cadherin_repeat	2675..2771	CDD:206637	28/99 (28%)
		Cadherin_repeat	2778..2870	CDD:206637	27/96 (28%)
		Cadherin_repeat	2878..2981	CDD:206637	32/111 (29%)
		Cadherin_repeat	2990..3085	CDD:206637	23/97 (24%)
		Cadherin_repeat	3095..3192	CDD:206637	26/96 (27%)
		Cadherin_repeat	3200..3295	CDD:206637	32/100 (32%)
		Cadherin_repeat	3305..3402	CDD:206637	29/104 (28%)
		Cadherin_repeat	3410..3508	CDD:206637	33/97 (34%)
		Cadherin_repeat	3516..3612	CDD:206637	24/97 (25%)
		EGF_CA	3804..3862	CDD:238011	10/70 (14%)
		EGF_CA	3864..3900	CDD:238011	11/52 (21%)
		EGF_CA	3902..3938	CDD:238011	12/39 (31%)
		EGF_CA	3941..3976	CDD:238011	8/34 (24%)
		LamG	3979..4142	CDD:238058	39/169 (23%)
		EGF_CA	4168..4200	CDD:238011	10/35 (29%)
		Laminin_G_2	4252..4375	CDD:396680	3/122 (2%)
		EGF_CA	4430..4464	CDD:238011	14/35 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100175
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810