Protein Alignment kug and Pcdh20

DIOPT Version :10

• Sequence 1: NP_001027138.2
• Gene: kug / 40191
• FlyBaseID: FBgn0261574
• Length: 4699
• Species: Drosophila melanogaster
• Sequence 2: NP_001100750.1
• Gene: Pcdh20 / 306081
• RGDID: 1306297
• Length: 952
• Species: Rattus norvegicus
• Alignment Length: 760
• Identity: 212/760 - (27%)
• Similarity: 339/760 - (44%)
• Gaps: 79/760 - (10%)

  Fly  2789 GNYTFKFSIAAD--QDHFMISD--SGEL-ILQQTLDRE--------------------QQESHNL 2828
            ||....||:|:.  ...::..|  |||| ...|.:|||                    ...|.:.
  Rat   113 GNPPLSFSLASGGLSGQYVTLDNRSGELHTSAQEIDREALCLDGGGGAAWGGSTSIASSPSSDSC 177

  Fly  2829 IVVAETSTVP-VFFAYADVLIDVRDENDNYPKFDNTFYSASVAENSEKVISL-VKVSATDADTGP 2891
            :::.:...:| .:|.:..|.|.:||.|||.|:|..:..|..|.|||.....| ::..|.|.|.|.
  Rat   178 LLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPISEISVWVPENSPVNTRLAIEHPAVDPDVGI 242

  Fly  2892 NGDIRYYLESDTENIQNIFDIDIYSG-------WITLLTSLDREVQSEYNFKVIAADNGHPKHDA 2949
            ||...|.|    .:...:|.:|:...       ::.::.:||||.|.:|...:||.|.|.|....
  Rat   243 NGVQTYRL----LDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLG 303

  Fly  2950 KVPVTIKIVDYNDNAPVFKLPIEGLSVFENALPGTVLINLLLIDPDIEKQEMDFFIVSGDKQAQF 3014
            ...:||.|.|.|||.|:|......::|:.||..||.:..:..:|.|:.......:..| .|..|
  Rat   304 SATLTIGISDINDNCPLFIDSQINVTVYGNATVGTPVTTVQAVDRDLGTNAQITYSYS-QKVPQ- 366

  Fly  3015 QIGKSGELF----------IAKPLDREQLMFYNLSIIAT-DGKFTAKANVEIDVKDINDNTPYCL 3068
               :|.|||          ::..:....|..:.|:|:|. .|...|.....:.:..:....|. :
  Rat   367 ---ESKELFHLDEVTGVVKLSSKIGGNVLQTHKLTILANGPGCIPAVITALVSIIKVVFRPPE-I 427

  Fly  3069 KPRYHISTNESI-------SIGTTLVEVKAIDFDFQSKLRFYLSGKGADDFSIG-----KESGIL 3121
            .|||..:..:.:       .:.|.:......|.:.:.|:..||.|:|  .|.:.     ....:|
  Rat   428 VPRYIANEMDGVVYLKELEPVNTPIAFFTIRDPEGKYKINCYLEGEG--PFRLAPYKPYNNEYLL 490

  Fly  3122 KVASALDRETTPKYKLVAHVQDGKDFTQECFSEIIITVNDINDNMPIFSMAQYRVSVPEDAQLNT 3186
            :....:|.|..|.|::.....:.:.|..:..  |.:.:.|.|||.|:|......:::.|:...|.
  Rat   491 ETTKPMDYELQPFYEIAVVAWNSEGFHDKRI--IKVQLLDDNDNAPVFLQPLIELTIEENNAPNA 553

  Fly  3187 LITKVHAMDKDFGVNRQIKYSLMGENHDYFKISKSTGIIRLHKSLDRETISLFNLTVKAEDCGVP 3251
            .:||::|.|.|.|...::.|.|..:...||.:...|||:.:...||||....:..||:|.|||.|
  Rat   554 FLTKLYATDADSGEMGRVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKP 618

  Fly  3252 KLHSIATVAVNILDINDNPPEFSMRQYSCKILENATHGTEVCKVYATSIDIGVNADIHYFIMSGN 3316
            ...|:||||:.:||.|||.|.|..:.:|..:.||.....|:..:..|..|.|.|..:...:|  |
  Rat   619 PRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVM--N 681

  Fly  3317 EQGKFKMDSTTGDLVLNATLDYEMSKFYFLTIQAIDGGTPPLSNNAYVNISILDINDNSPTFL-- 3379
            :...|.:|:..|.|....:||.|....|.|.::|:|||.|.||:...:.|.:||||||.|..|
  Rat   682 QSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTTKITILLLDINDNPPLVLFP 746

  Fly  3380 -QNLYRINVNEDIFVGSKILDVKATDEDSDVNGLVTYNI--ERGDNIGQFSIDPKNGTISVSRPL 3441
             .|:..:.|......||.:.:|.|.|:|:.:|.::.|:|  .||.....|.||||.|.|::...|
  Rat   747 QSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEAL 811

  Fly  3442 DRETISHYTLEIQACDQGDPQRCNS-VPININILDTNDNAPIFSS 3485
            .:.....:.|.::..|.|.|:..:| |.:|:.:.||..|.....|
  Rat   812 LQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIES 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kug	NP_001027138.2	Cadherin_repeat	66..178	CDD:206637
		Cadherin_repeat	187..285	CDD:206637
		Cadherin_repeat	404..503	CDD:206637
		Cadherin_repeat	513..609	CDD:206637
		Cadherin_repeat	622..708	CDD:206637
		Cadherin_repeat	776..873	CDD:206637
		Cadherin_repeat	883..976	CDD:206637
		Cadherin_repeat	984..1082	CDD:206637
		Cadherin_repeat	1092..1189	CDD:206637
		Cadherin_repeat	1197..1295	CDD:206637
		Cadherin_repeat	1303..1386	CDD:206637
		Cadherin_repeat	1413..1502	CDD:206637
		Cadherin_repeat	1510..1608	CDD:206637
		Cadherin_repeat	1621..1713	CDD:206637
		Cadherin_repeat	1724..1811	CDD:206637
		Cadherin_repeat	1819..1927	CDD:206637
		Cadherin_repeat	1948..2030	CDD:206637
		Cadherin_repeat	2037..2136	CDD:206637
		Cadherin_repeat	2144..2235	CDD:206637
		Cadherin_repeat	2246..2336	CDD:206637
		Cadherin_repeat	2345..2445	CDD:206637
		Cadherin_repeat	2453..2545	CDD:206637
		Cadherin_repeat	2555..>2633	CDD:206637
		Cadherin_repeat	2658..2759	CDD:206637
		Cadherin_repeat	2774..2856	CDD:206637	22/92 (24%)
		Cadherin_repeat	2865..2963	CDD:206637	32/105 (30%)
		Cadherin_repeat	2974..3063	CDD:206637	20/99 (20%)
		Cadherin_repeat	3072..3165	CDD:206637	18/104 (17%)
		Cadherin_repeat	3173..3269	CDD:206637	34/95 (36%)
		Cadherin_repeat	3277..3374	CDD:206637	31/96 (32%)
		Cadherin_repeat	3383..3479	CDD:206637	29/98 (30%)
		Cadherin_repeat	3488..3579	CDD:206637
		Cadherin_repeat	3590..3681	CDD:206637
		EGF_CA	3866..3903	CDD:238011
		Laminin_G_2	3953..4077	CDD:460494
		EGF_CA	<4121..4150	CDD:238011
		EGF_CA	4152..4189	CDD:238011
		EGF_CA	4195..4225	CDD:238011
		EGF_CA	4227..4262	CDD:214542
Pcdh20	NP_001100750.1	Cadherin_2	70..>153	CDD:462413	14/39 (36%)
		Cadherin_repeat	214..317	CDD:206637	32/106 (30%)
		Cadherin_repeat	325..417	CDD:206637	20/96 (21%)
		CA_like	439..>510	CDD:481204	13/72 (18%)
		CA_like	<490..534	CDD:481204	11/45 (24%)
		Cadherin_repeat	541..636	CDD:206637	34/94 (36%)
		Cadherin_repeat	645..739	CDD:206637	31/95 (33%)
		Cadherin_repeat	755..846	CDD:206637	27/90 (30%)