DRSC/TRiP Functional Genomics Resources

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Protein Alignment kug and Pcdhb4

DIOPT Version :10

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:NP_001108073.1 Gene:Pcdhb4 / 291655 RGDID:1308912 Length:779 Species:Rattus norvegicus


Alignment Length:808 Identity:215/808 - (26%)
Similarity:330/808 - (40%) Gaps:166/808 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   780 SINESVQLGETVAWIEAKDRDLGYN-GKLV---FAISDGDYDSVFRIDPDRGELQIIGYLDRE-- 838
            |:.|..:.|..||.:.   :|||.. |:|.   ..|.......:.::|.:.|.|.:...||||  
  Rat    34 SMPEETESGYLVANLA---KDLGLRVGELATRGARIHHRGNKELLQLDAETGNLFLKEKLDREVL 95

  Fly   839 --RQNEYVLNITVYDLGNPTKSTSKMLPITILDVNDNRPVIQKTLATFRLTESARIGTVVHCLHA 901
              .....||...:. |.||.:.....|.:|  |:||:.|....|.....:.||.:.|||.....|
  Rat    96 CGLTEPCVLQFQII-LKNPVQFFQTELQLT--DINDHAPEFPDTEMLLTIPESVQPGTVFPLKAA 157

  Fly   902 TDADSGINAQVTYALS--VECSDFTVNATTGC----LRLNKPLDREKQDNYALHITAKDGGSPVL 960
            .|:|.|.||...|.:|  :.....|.:.|.|.    |.|::.||||:|....|.:||.|||:|..
  Rat   158 QDSDIGSNAVQNYTVSPNLHFHVVTHSRTDGRKYPELVLDRALDREEQPELTLILTALDGGAPRR 222

  Fly   961 SSEALVYVLVDDVNDNAPVFGVQEYIFKVREDLPRGTVLAVIEAVDEDIGPNAEIQFSLKEETQD 1025
            |....|::.|.|:|||||.|....|..:|.|::|...::..:.|.|.|.|....:.:||.:.::|
  Rat   223 SGMTAVHIEVVDINDNAPQFVQSLYEVQVPENIPLDALVVTVSATDLDAGIYGNVAYSLFQGSRD 287

  Fly  1026 EELFRIDKHTGAIRTQGYLDYENKQVHNLIVSAIDGGDPSLTSDMSIVIMIIDVNENRFAPEFDD 1090
            .:.|.||:.||.||....||:|....:|:.::|:|||  .|:...::.:.::|||:|  |||...
  Rat   288 SQPFIIDEITGEIRLSKELDFEVTPYYNVEIAAVDGG--GLSGKCTVAVQVLDVNDN--APELTI 348

  Fly  1091 FVYEGKVKENKPKGTFVMNVTARDMDTVDLNSKITYSITGGDGLGIFAVNDQGSITSLSQLDAET 1155
            ..:...|.||.|: |.|:.....|.|:.| |.::..||             |..:..|  |.:..
  Rat   349 STFSSPVPENSPE-TVVLVFGVFDQDSGD-NGRMVCSI-------------QNELPFL--LKSTF 396

  Fly  1156 KNFYWLTLCAQDCAIVPLSNCVEVYIQVENENDNIPLTDKPVYYVNVTEASVENVEIITLKAFDP 1220
            :|:|.|                                                           
  Rat   397 ENYYTL----------------------------------------------------------- 402

  Fly  1221 DIDPTQTITYNIVSGNLVGYFEIDSKTGVIKTTERKLDRENQAEHILEVAISDNGSPVLSSTSRI 1285
                                           .|||.||||::||:.:.:.:||.|:|.|::...|
  Rat   403 -------------------------------VTERPLDRESRAEYNITITVSDLGTPRLTTQHTI 436

  Fly  1286 VVSVLDINDNSPEFDQRVYKVQVPSSATVNQSIFQVHAIDSDSGENGRITYSIKSGKG-----KN 1345
            .|.|.|||||:|.|.|..|.:.|..:.:....|..:.|.|||||.|..||||:.....     .:
  Rat   437 TVKVSDINDNAPSFTQTSYTMFVHENNSPALHIGTISATDSDSGSNAHITYSLLPPDDPQLDLDS 501

  Fly  1346 KFRIDSQRGHIHIAKPLDSD--NEFEIHIKAEDNGIPKKSQTARVNIVVVPVNPNSQNAPLIVRK 1408
            ...|::..|.:...:.||.:  ..||..:.|.|.|.|..|..|.|::||:..|   .|.|.::..
  Rat   502 LISINADNGQLFALRALDYEALQSFEFLVGATDEGSPALSSQALVHVVVLDDN---DNVPFVLYP 563

  Fly  1409 TSENVVDLTE----NDKPGFLVTQILAVDDDNDQ---LWYNISNGNDDNTFYIGQDNGNILLSKY 1466
            ........||    ..:||:|||:::|||.|:.|   |.:.:....:...|.:...||.:..::.
  Rat   564 LQNASPPCTELLPRAAEPGYLVTKVVAVDQDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTARL 628

  Fly  1467 LDYETQQSYNLTISVTDGTFTAFTNLLVQVIDINDNPPQFAKDVYHVNISENIEEESVIMQLHAT 1531
            |.......:.|.:.|.|                |..|.:.|....||.:.:...:..:.:...|.
  Rat   629 LSERDVPKHKLLLLVKD----------------NGEPQRSASVTLHVLLVDGFSQPYLPLPEVAL 677

  Fly  1532 D--RDEDKKLFYHLHATQDPSSLALFRI 1557
            |  .|||....|.:.|....|||.|..:
  Rat   678 DPTYDEDNLTLYLVVALASVSSLFLLSV 705

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637 27/100 (27%)
Cadherin_repeat 883..976 CDD:206637 35/98 (36%)
Cadherin_repeat 984..1082 CDD:206637 30/97 (31%)
Cadherin_repeat 1092..1189 CDD:206637 18/96 (19%)
Cadherin_repeat 1197..1295 CDD:206637 20/97 (21%)
Cadherin_repeat 1303..1386 CDD:206637 25/89 (28%)
Cadherin_repeat 1413..1502 CDD:206637 21/95 (22%)
Cadherin_repeat 1510..1608 CDD:206637 13/50 (26%)
Cadherin_repeat 1621..1713 CDD:206637
Cadherin_repeat 1724..1811 CDD:206637
Cadherin_repeat 1819..1927 CDD:206637
Cadherin_repeat 1948..2030 CDD:206637
Cadherin_repeat 2037..2136 CDD:206637
Cadherin_repeat 2144..2235 CDD:206637
Cadherin_repeat 2246..2336 CDD:206637
Cadherin_repeat 2345..2445 CDD:206637
Cadherin_repeat 2453..2545 CDD:206637
Cadherin_repeat 2555..>2633 CDD:206637
Cadherin_repeat 2658..2759 CDD:206637
Cadherin_repeat 2774..2856 CDD:206637
Cadherin_repeat 2865..2963 CDD:206637
Cadherin_repeat 2974..3063 CDD:206637
Cadherin_repeat 3072..3165 CDD:206637
Cadherin_repeat 3173..3269 CDD:206637
Cadherin_repeat 3277..3374 CDD:206637
Cadherin_repeat 3383..3479 CDD:206637
Cadherin_repeat 3488..3579 CDD:206637
Cadherin_repeat 3590..3681 CDD:206637
EGF_CA 3866..3903 CDD:238011
Laminin_G_2 3953..4077 CDD:460494
EGF_CA <4121..4150 CDD:238011
EGF_CA 4152..4189 CDD:238011
EGF_CA 4195..4225 CDD:238011
EGF_CA 4227..4262 CDD:214542
Pcdhb4NP_001108073.1 Cadherin_2 30..112 CDD:462413 21/81 (26%)
Cadherin_repeat 140..238 CDD:206637 35/97 (36%)
Cadherin_repeat 247..342 CDD:206637 30/96 (31%)
Cadherin_repeat 355..446 CDD:206637 38/197 (19%)
Cadherin_repeat 454..556 CDD:206637 30/104 (29%)
Cadherin_repeat 575..663 CDD:206637 23/103 (22%)
Cadherin_C_2 685..768 CDD:465139 6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

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