DRSC/TRiP Functional Genomics Resources

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Protein Alignment kug and PCDHGA12

DIOPT Version :10

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:NP_003726.1 Gene:PCDHGA12 / 26025 HGNCID:8699 Length:932 Species:Homo sapiens


Alignment Length:694 Identity:201/694 - (28%)
Similarity:316/694 - (45%) Gaps:68/694 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   780 SINESVQLGETVAWIEAKDRDLGYNGKLV----FAISDGDYDSVFRIDPDRGELQIIGYLDRER- 839
            |:.|.::.|..|..|   .||||...:.:    ..|.......:|.::|..|.|...|.:|||. 
Human    34 SVPEELEKGSRVGDI---SRDLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGRIDREEL 95

  Fly   840 -----QNEYVLNITVYDLGNPTKSTSKMLPITILDVNDNRPVIQKTLATFRLTESARIGTVVHCL 899
                 :.:..|:|.:.|     |.....:.:.:.|:|||.|..:::....:::|:|.........
Human    96 CMGAIKCQLNLDILMED-----KVKIYGVEVEVRDINDNAPYFRESELEIKISENAATEMRFPLP 155

  Fly   900 HATDADSGINAQVTYALSVECSDFTVNATTGC-------LRLNKPLDREKQDNYALHITAKDGGS 957
            ||.|.|.|.|:..:|.||.. :.|::....|.       |.|.:.||||::..:.|.:||.|||.
Human   156 HAWDPDIGKNSLQSYELSPN-THFSLIVQNGADGSKYPELVLKRALDREEKAAHHLVLTASDGGD 219

  Fly   958 PVLSSEALVYVLVDDVNDNAPVFGVQEYIFKVREDLPRGTVLAVIEAVDEDIGPNAEIQFSLK-E 1021
            ||.:..|.:.|:|.|.|||||.|...||...|.|:|..||.|.|:.|.|.|.|.|||:::|.: .
Human   220 PVRTGTARIRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYV 284

  Fly  1022 ETQDEELFRIDKHTGAIRTQGYLDYENKQVHNLIVSAIDGGDPSLTSDMSIVIMIIDVNENRFAP 1086
            :.:..::|::|.::|.|.|.|.||:|....:.:.|.|:|....|..:  .::|.::|||:|  ||
Human   285 DDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYSARA--KVLITVLDVNDN--AP 345

  Fly  1087 EFDDFVYEGKVKENKPKGTFVMNVTARDMDTVDLNSKITYSITGGDGLGIFAVNDQGSITSLSQ- 1150
            |.........|.||.|:||.:..:...|.|:.: |.::...|.|  .|........|:..||.. 
Human   346 EVVLTSLASSVPENSPRGTLIALLNVNDQDSEE-NGQVICFIQG--NLPFKLEKSYGNYYSLVTD 407

  Fly  1151 --LDAETKNFYWLTLCAQDCAIVPLSNCVEVYIQVENENDNIPLTDKPVYYVNVTEASVENVEII 1213
              ||.|....|.:|:.|.|....|||....:.:.|.:.|||.|:..:..|...:.|.:...|.::
Human   408 IVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLV 472

  Fly  1214 TLKAFDPDIDPTQTITYNIVSGNLVG-----YFEIDSKTGVIKTTERKLDRENQAEHILEVAISD 1273
            ::.|.|||.:....|||::....:.|     |..|:|.|||:.... ..|.|...:..::|...|
Human   473 SVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALS-SFDYEQFRDLQVKVMARD 536

  Fly  1274 NGSPVLSSTSRIVVSVLDINDNSPEF-------DQRVYKVQVPSSATVNQSIFQVHAIDSDSGEN 1331
            ||.|.|||...:.:.|||.|||:||.       |........|.||.....:.:|.|:|.|||:|
Human   537 NGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 601

  Fly  1332 GRITYSIKSGKGKNKFRIDSQRGHIHIAKP-LDSDN-EFEIHIKAEDNGIPKKSQTARVNIVVVP 1394
            ..::|.:........|.:....|.:..|:. ||.|. :..:.:..:|:|.|..|.|..:.:.|..
Human   602 AWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVAD 666

  Fly  1395 VNP------NSQNAPLIVRKTSENVVDLTENDKPGFLVTQILAV 1432
            ..|      .|..:|     .:....|||.     :||..:.||
Human   667 SIPQVLADLGSLESP-----ANSETSDLTL-----YLVVAVAAV 700

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637 24/102 (24%)
Cadherin_repeat 883..976 CDD:206637 32/99 (32%)
Cadherin_repeat 984..1082 CDD:206637 34/98 (35%)
Cadherin_repeat 1092..1189 CDD:206637 27/99 (27%)
Cadherin_repeat 1197..1295 CDD:206637 31/102 (30%)
Cadherin_repeat 1303..1386 CDD:206637 21/84 (25%)
Cadherin_repeat 1413..1502 CDD:206637 7/20 (35%)
Cadherin_repeat 1510..1608 CDD:206637
Cadherin_repeat 1621..1713 CDD:206637
Cadherin_repeat 1724..1811 CDD:206637
Cadherin_repeat 1819..1927 CDD:206637
Cadherin_repeat 1948..2030 CDD:206637
Cadherin_repeat 2037..2136 CDD:206637
Cadherin_repeat 2144..2235 CDD:206637
Cadherin_repeat 2246..2336 CDD:206637
Cadherin_repeat 2345..2445 CDD:206637
Cadherin_repeat 2453..2545 CDD:206637
Cadherin_repeat 2555..>2633 CDD:206637
Cadherin_repeat 2658..2759 CDD:206637
Cadherin_repeat 2774..2856 CDD:206637
Cadherin_repeat 2865..2963 CDD:206637
Cadherin_repeat 2974..3063 CDD:206637
Cadherin_repeat 3072..3165 CDD:206637
Cadherin_repeat 3173..3269 CDD:206637
Cadherin_repeat 3277..3374 CDD:206637
Cadherin_repeat 3383..3479 CDD:206637
Cadherin_repeat 3488..3579 CDD:206637
Cadherin_repeat 3590..3681 CDD:206637
EGF_CA 3866..3903 CDD:238011
Laminin_G_2 3953..4077 CDD:460494
EGF_CA <4121..4150 CDD:238011
EGF_CA 4152..4189 CDD:238011
EGF_CA 4195..4225 CDD:238011
EGF_CA 4227..4262 CDD:214542
PCDHGA12NP_003726.1 Cadherin_2 30..112 CDD:462413 20/80 (25%)
Cadherin_repeat 137..238 CDD:206637 32/101 (32%)
Cadherin_repeat 246..343 CDD:206637 34/98 (35%)
Cadherin_repeat 355..448 CDD:206637 27/95 (28%)
Cadherin_repeat 456..558 CDD:206637 31/102 (30%)
Cadherin_repeat 579..666 CDD:206637 23/86 (27%)
Cadherin_C_2 688..772 CDD:465139 7/18 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 803..841
Cadherin_tail 811..>905 CDD:435046
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 902..932
Blue background indicates that the domain is not in the aligned region.

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